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Demethylation of ribosomal RNA by hepatocyte microsomal preparations.

Abstract：

:Previous work has shown that hypomethylation of rRNA is an important control for protein synthesis in rat hepatocytes, and that the net hypomethylation appears to arise from cytoplasmic events. Here we show that demethylation of rRNA is catalyzed by microsomal preparations. The rRNA demethylation is dependent upon NADPH and is almost completely inhibited by carbon monoxide. Demethylation appears to increase following galactosamine intoxication, a hepatotoxin which induces hypomethylation of rRNA and inhibition of protein synthesis.

journal_name

Life Sci

journal_title

Life sciences

authors

Choe WT,Hatem CL,Clawson GA

doi

10.1016/0024-3205(91)90283-h

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

1585-9

issue

16

eissn

0024-3205

issn

1879-0631

pii

0024-3205(91)90283-H

journal_volume

48

pub_type

杂志文章

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