Abstract：
:Neuropeptide Y (NPY) is a 36 amino acid peptide released in central and peripheral mammalian neurons, which appears to contribute to adiposity regulation by increasing food intake, thus promoting weight gain on animals. Nevertheless, little is known about NPY direct actions on white adipocytes. This trial, which was designed to test the possible effects of a new NPY antagonist, S.A.0204, on white adipose tissue, revealed that the administration of this novel molecule strongly ex vivo stimulates apoptosis and lipolysis in animals fed on a high-fat diet.
journal_name
Life Scijournal_title
Life sciencesauthors
Margareto J,Aguado M,Osés-Prieto JA,Rivero I,Monge A,Aldana I,Marti A,Martínez JAdoi
10.1016/s0024-3205(00)00916-4subject
Has Abstractpub_date
2000-11-24 00:00:00pages
99-107issue
1eissn
0024-3205issn
1879-0631pii
S0024320500009164journal_volume
68pub_type
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