Bupivacaine kinetic changes induced by diltiazem in mice.

abstract：AIMS:Baicalein is a widely used Chinese herbal medicine extracted from Labiatae plants Scutellaria baicalensis Georgi's dry root, which has multiple pharmacological activities. However, the precise mechanism of baicalein against myocardial remodeling remains poorly understood. The aim of our study was to investigate th...

journal_title：Life sciences

authors： Zhao F,Fu L,Yang W,Dong Y,Yang J,Sun S,Hou Y

更新日期：2016-01-15 00:00:00

abstract：AIM:The effects of local applied NO-active compounds on glutamate (GLU)-evoked responses were investigated in globus pallidus (GP) neurons. MAIN METHODS:Extracellularly recorded single units from anesthetized rats were treated with GLU before and during the microiontophoretic application of S-nitrosoglutathione (SNOG)...

journal_title：Life sciences

authors： Sardo P,Carletti F,Rizzo V,Lonobile G,Friscia S,Ferraro G

更新日期：2011-06-20 00:00:00

abstract：:Previous studies showed that acute treatment with aminophylline (AMPY) significantly elevated maximum thermogenesis and improved cold tolerance in rats and man in severe cold. However, the exact mechanism by which AMPY enhances thermogenesis was unknown. Rats receiving enprofylline (ENPRO) (1.5 and 15 mg/kg, i.p.), a ...

journal_title：Life sciences

authors： Wang LC,Jourdan ML,Lee TF

更新日期：1989-01-01 00:00:00

abstract：:Type-II iodothyronine 5'-deiodinase activity (5'-D) in both anterior pituitary and pineal was significantly elevated at 2400 h, approximately 0.5- and 20-fold higher than the noon value, respectively. The nocturnal rise in both organs was abolished by 6 h additional light. Short-term constant darkness did not alter 5'...

journal_title：Life sciences

authors： Murakami M,Greer MA,Greer SE,Hjulstad S,Tanaka K

更新日期：1988-01-01 00:00:00

abstract：:The injection of neostigmine into the hippocampus of anesthetized rats increased the mean arterial blood pressure (17% of baseline after 60 min injection) and decreased the heart rate (24% of baseline after 60 min injection). These changes were blocked by the co-administration of methylatropine into the hippocampus. I...

journal_title：Life sciences

authors： Haruta K,Iguchi A,Matsubara T,Itoh K,Chen CL,Yoshida S,Terada R,Kanashiro M,Suzuki O,Nishimura H

更新日期：1992-01-01 00:00:00

abstract：:A microiontophoretic study using rats anesthetized with chloral hydrate and immobilized with gallamine triethiodide was carried out to compare the effect of talipexole (B-HT 920 CL2:2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo [4,5-d]-azepine-dihydrochloride), a dopamine autoreceptor agonist, on dopaminergic neurons...

journal_title：Life sciences

authors： Momiyama T,Sasa M,Takaori S

更新日期：1991-01-01 00:00:00

abstract：:Liquid protein diet (LPD) has been shown previously to produce maternal and fetal weight loss and fetal congenital anomalies, including cataracts and craniofacial malformations. Therefore, to examine the effects of LPD in pregnancy upon the central nervous system of pups, pregnant dams were fed either a 20% casein die...

journal_title：Life sciences

authors： Mori M,Wilber JF,Nakamoto T

更新日期：1983-04-04 00:00:00

abstract：:It has been shown that some cytochrome P450-dependent enzyme activities could present daily fluctuations, particularly CYP3A isoenzymes which are enhanced during the dark period. The aim of this study was to investigate whether age and photoperiodic conditions at different circadian stages could influence these fluctu...

journal_title：Life sciences

authors： Martin C,Dutertre-Catella H,Radionoff M,Debray M,Benstaali C,Rat P,Thevenin M,Touitou Y,Warnet JM

更新日期：2003-06-06 00:00:00

abstract：:The adverse effects of prenatal nicotine and alcohol exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, substantial percentage of women (20-25%) of childbearing age currently smoke cigarettes and consume alcohol, and only a small percentage of these individu...

journal_title：Life sciences

authors： Bhattacharya D,Majrashi M,Ramesh S,Govindarajulu M,Bloemer J,Fujihashi A,Crump BR,Hightower H,Bhattacharya S,Moore T,Suppiramaniam V,Dhanasekaran M

更新日期：2018-02-01 00:00:00

abstract：:Two types of plasma membranes isolated from rat brain cortex were used to study the membrane-perturbing properties of ethanol. Rats administered ethanol in the form of a liquid diet showed an increase in levels of phosphatidylserines, phosphatidylinositols and phosphatidic acids as compared to controls. The results pr...

journal_title：Life sciences

authors： Sun GY,Huang HM,Lee DZ,Sun AY

更新日期：1984-11-19 00:00:00

abstract：:We examined the effect of 7-OH-DPAT on spontaneous locomotor activity that is enhanced in diabetic mice. 7-OH-DPAT (0.1-30 mg/kg, s.c.) dose-dependently decreased the enhanced spontaneous locomotor activity in diabetic mice, but not in nondiabetic mice. When mice were pretreated with of 7-OH-DPAT (0.1 mg/kg), morphine...

journal_title：Life sciences

authors： Kamei J,Saitoh A

更新日期：1996-01-01 00:00:00

abstract：:The present report investigated whether percentages of circulating natural killer (NK) cells and NK cell activity (NKCA) are associated with psychological variables. Subjects (n = 95) were selected, based on a combination of low or high scores on questionnaires on daily hassles and self-reported symptoms, to create fo...

journal_title：Life sciences

authors： Benschop RJ,Jabaaij L,Oostveen FG,Vingerhoets AJ,Kirschbaum C,Duivenvoorden HJ,Ballieux RE

更新日期：1993-01-01 00:00:00

abstract：:Anandamide (arachidonylethanolamide), isolated from porcine brain, has been shown to bind to the cannabinoid receptor and also to produce cannabimimetic activity in pharmacological assays. This study examined structure-activity relationships in alkylated anandamide analogs. The analogs were evaluated for their ability...

journal_title：Life sciences

authors： Adams IB,Ryan W,Singer M,Razdan RK,Compton DR,Martin BR

更新日期：1995-01-01 00:00:00

abstract：:The role of FSH in inducing folliculogenesis is well established. Recently, the availability of pure FSH has led to a reevaluation of its role in the process of ovulation. Previously, these functions have been examined separately, usually with pregnant mares' serum gonadotropin (PMSG) followed by FSH for ovulation or ...

journal_title：Life sciences

authors： Rice VC,Zusmanis K,Malter H,Mitchell-Leef D

更新日期：1993-01-01 00:00:00

abstract：:Uncontrolled recreational drugs are proliferating in number and variety. Effects of long-term use are unknown, and regulation is problematic, as efforts to control one chemical often lead to several other structural analogs. Advanced analytical instrumentation and methods are continuing to be developed to identify dru...

journal_title：Life sciences

authors： Thomas BF,Pollard GT,Grabenauer M

更新日期：2013-03-19 00:00:00

abstract：:Although both the incidence and the mortality rate of breast cancer is rising, there is no potent and practical option for the treatment of these patients, particularly in advanced stages. One of the most critical challenges for treatment is the presence of complicated and extensive tumor escape mechanisms in the tumo...

journal_title：Life sciences

authors： Bastaki S,Irandoust M,Ahmadi A,Hojjat-Farsangi M,Ambrose P,Hallaj S,Edalati M,Ghalamfarsa G,Azizi G,Yousefi M,Chalajour H,Jadidi-Niaragh F

更新日期：2020-04-15 00:00:00

abstract：:We aimed to study the alterations in serum homocysteine levels and endothelium-dependent and -independent vascular relaxant responses in adjuvant-induced arthritis of the rat and to determine the effects of vitamin E administration on these changes. Arthritis was induced by a single intradermal injection of Freund's c...

journal_title：Life sciences

authors： Can C,Cinar MG,Koşay S,Evinç A

更新日期：2002-06-14 00:00:00

abstract：:A simple procedure has been developed for the large scale purification of fetal bovine serum acetylcholinesterase (AChE) (EC 3.1.1.7). The procedure involves two steps: batch adsorption of the AChE from 250 L of serum onto a procainamide affinity Sepharose 4B gel; and analytical procainamide affinity chromatography of...

journal_title：Life sciences

authors： De la Hoz D,Doctor BP,Ralston JS,Rush RS,Wolfe AD

更新日期：1986-07-21 00:00:00

abstract：AIMS:We previously found that paeoniflorin, a major constituent of Paeonia lactiflora Pall, could induce heat shock proteins (HSPs) in cultured mammalian cells without apparent toxicity (Yan et al. 2004). We here investigated the induction of HSPs by paeoniflorin in mouse stomach and the effect of paeoniflorin on the H...

journal_title：Life sciences

authors： Asai M,Kawashima D,Katagiri K,Takeuchi R,Tohnai G,Ohtsuka K

更新日期：2011-02-14 00:00:00

abstract：:18-Hydroxycorticosterone (18-OHB) is a precursor of aldosterone and is the only corticosteroid, other than aldosterone, that is synthesized predominantly in the zona glomerulosa. Administration of the dopamine antagonist, metoclopramide results in parallel rises in plasma 18-OHB and aldosterone levels without affectin...

journal_title：Life sciences

authors： Sowers JR,Beck FW,Stern N

更新日期：1983-12-19 00:00:00

abstract：:Morphine and oxycodone are potent opioid analgesics most commonly used for the management of moderate to severe acute and chronic pain. Their clinical utility is limited by undesired side effects like analgesic tolerance, dependence, and withdrawal. We have previously demonstrated that endothelin-A (ETA) receptor anta...

journal_title：Life sciences

authors： Bhalla S,Andurkar SV,Gulati A

更新日期：2016-08-15 00:00:00

abstract：:We examined the effect of beta-alanyl-L-histidinato zinc (AHZ) on the differentiation of human periodontal ligament (HPDL) cells. HPDL cells were cultured with alpha-minimum essential medium containing 10% fetal bovine serum with or without 10(-4) or 10(-5) M AHZ for up to 10 days. The expression of runt-related trans...

journal_title：Life sciences

authors： Maeno M,Ito-Kato E,Suzuki N,Takada T,Takayama T,Ito K,Otsuka K

更新日期：2004-04-02 00:00:00

abstract：AIMS:This experiment investigated the effects of sub-chronic aluminum chloride (AlCl3) exposure on rat ovaries. MAIN METHODS:Eighty female Wistar (5weeks old) rats, weighed 110-120g, were randomly divided into four treatment groups: control group (CG), low-dose group (LG, 64mg/kg BW AlCl3), mid-dose group (MG, 128mg/k...

journal_title：Life sciences

authors： Fu Y,Jia FB,Wang J,Song M,Liu SM,Li YF,Liu SZ,Bu QW

更新日期：2014-03-28 00:00:00

abstract：:Hypertension is closely associated with vascular endothelial dysfunction. The aim of this study was to investigate the effects of Angiotensin II (ANG II) receptor antagonist losartan on the blood-brain barrier (BBB) permeability in L-NAME-induced hypertension and/or in ANG II-induced acute hypertension in normotensive...

journal_title：Life sciences

authors： Kucuk M,Kaya M,Kalayci R,Cimen V,Kudat H,Arican N,Elmas I,Korkut F

更新日期：2002-07-12 00:00:00

abstract：AIMS:The natural phenolic oil compound hydroxytyrosol (HTy) is widely studied because of its antioxidant and neuroprotective properties. Nitroderivatives of HTy have been studied in order to evaluate their putative effects on catechol-O-methyltransferase (COMT) activity. MAIN METHODS:To study its effect on dopamine me...

journal_title：Life sciences

authors： Gallardo E,Madrona A,Palma-Valdés R,Espartero JL,Santiago M

更新日期：2015-08-01 00:00:00

abstract：:The regions of muscarinic receptors that specify G-protein-coupling and ligand-binding have been defined in several recent studies. Overall, these studies have shown that amino acids within the third cytoplasmic loop of the receptors define their selectivity for different G-proteins, and that multiple, discontinuous e...

journal_title：Life sciences

authors： Brann MR,Klimkowski VJ,Ellis J

更新日期：1993-01-01 00:00:00

abstract：:Transcription factor Gata3 is implicated in the formation of autosomal dominant hypoparathyroidism, sensorineural deafness, and renal anomaly (HDR) syndrome. We pursued to identify the potential Gata3 target genes by profiling the gene expression pattern in E9.5 Gata3-/- mouse embryos. Altogether four independent micr...

journal_title：Life sciences

authors： Airik R,Kärner M,Karis A,Kärner J

更新日期：2005-04-15 00:00:00

abstract：:The effect of thapsigargin, a specific inhibitor of intracellular Ca(2+)-ATPases, on endothelium-dependent relaxation was studied in the guinea pig thoracic aorta. Thapsigargin (1 nM-1 microM) produced a concentration-dependent relaxation of aortic strips precontracted by phenylephrine (0.1 microM) in the presence and...

journal_title：Life sciences

authors： Matsuyama S,Shuntoh H,Katayama S,Tanaka C

更新日期：1993-01-01 00:00:00

abstract：AIMS:Fudosteine is a cysteine derivative that is used as an expectorant in chronic bronchial inflammatory disorders. It has been shown to decrease the number of goblet cells in an animal model. This study examined the effects of fudosteine on airway inflammation and remodeling in a murine model of chronic asthma. MAIN...

journal_title：Life sciences

authors： Ueno-Iio T,Shibakura M,Iio K,Tanimoto Y,Kanehiro A,Tanimoto M,Kataoka M

更新日期：2013-05-30 00:00:00

abstract：:The aim of the present study was to determine the role of adrenals in gonadal activity in the male toad during the breeding season. Exogenous administration of corticosterone or metapyrone for 6 days inhibited adrenal delta5-3beta(delta 5-3 beta) hydroxysteroid (delta5-3beta-HSD) and testicular 17beta (17 beta) hydrox...

journal_title：Life sciences

authors： Biswas NM,Chaudhuri GR,Sarkar M,Sengupta R

更新日期：2000-02-18 00:00:00