Abstract：
:The injection of neostigmine into the hippocampus of anesthetized rats increased the mean arterial blood pressure (17% of baseline after 60 min injection) and decreased the heart rate (24% of baseline after 60 min injection). These changes were blocked by the co-administration of methylatropine into the hippocampus. Intrahippocampal injection of neostigmine stimulated the secretion of epinephrine and norepinephrine. Adrenodemedullation did not suppress the increase in blood pressure and the decrease in heart rate. It is concluded that the stimulation of muscarinic cholinoceptive neurons in the hippocampus evokes a hypertensive response via an increase in sympathetic drive to the heart and peripheral vasculature, with bradycardia possibly mediated via the parasympathetic system.
journal_name
Life Scijournal_title
Life sciencesauthors
Haruta K,Iguchi A,Matsubara T,Itoh K,Chen CL,Yoshida S,Terada R,Kanashiro M,Suzuki O,Nishimura Hdoi
10.1016/0024-3205(92)90377-2subject
Has Abstract,Author List Incompletepub_date
1992-01-01 00:00:00pages
427-33issue
6eissn
0024-3205issn
1879-0631pii
0024-3205(92)90377-2journal_volume
50pub_type
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