Preparation of highly purified momordin II without ribonuclease activity.

abstract：:A previously unreported anti-bacterial activity against Escherichia coli has been found in porcine and bovine sera, but not in human or chicken sera. The activity is not affected by heat inactivation of the complement system, and is bacteriostatic rather than bactericidal. Growth inhibition is reversible by addition o...

journal_title：Life sciences

authors： Lenard J,VanDeroef R

更新日期：1995-01-01 00:00:00

abstract：:Kappa (kappa) opioid agonists induce a water diuresis and inhibit vasopressin (AVP) secretion. Hypothalamic and neurohypophysial sites have both been implicated in the response. The present study was designed to ascertain if kappa-agonist inhibition of osmotically-stimulated AVP secretion is associated with parallel c...

journal_title：Life sciences

authors： Rossi NF,Kim JK,Summers SN,Schrier RW

更新日期：1997-01-01 00:00:00

abstract：:Sexual interactions have multiple effects on oxytocin systems in the brain. In the present study we observed that allowing estrogen-progesterone treated ovariectomized rats to be mounted ten times by a male significantly decreased the density (beta max) of thymic oxytocin receptors. Animals were ovariectomized and aft...

journal_title：Life sciences

authors： Caldwell JD,Walker CH,Pedersen CA,Mason GA

更新日期：1993-01-01 00:00:00

abstract：:Silica (SiO2) nanoparticles (NPs) were synthesized by laser ablation method and were characterized by TEM and DLS techniques. Afterwards, their inhibition activity against carbonic anhydrase (CA) isoforms (CA I and CA II) was explored by experimental and theoretical analysis. Also, the protective effect of SiO2 NPs ag...

journal_title：Life sciences

authors： Xu N,Lu W,Meng L,Feng X,Xuan J,Liu F,Feng Z

更新日期：2021-01-12 00:00:00

abstract：:Kinetics of activation of the NADPH oxidase in a fully soluble cell-free system from phorbol myristate acetate (PMA)-stimulated human neutrophils were investigated. In a cell-free system in which Mg2+ and sodium dodecyl sulfate, an anionic detergent required for the activation of NADPH oxidase are contained, cytosol p...

journal_title：Life sciences

authors： Umeki S

更新日期：1990-01-01 00:00:00

abstract：AIMS:microRNA-96 (miR-96) is considered as a tumor suppressor in multiple malignancies. Some studies have indicated that EZRIN could be regulated by the miR-96 in several kinds of cancer cells. However, the function of miR-96 in human osteosarcoma has not been investigated intensively so far. In this study, we mainly e...

journal_title：Life sciences

authors： Yao Q,Pei Y,Zhang X,Xie B

更新日期：2018-06-15 00:00:00

abstract：:Since moderate hyperhomocysteinemia is an independent risk factor for vascular disease by mean of its oxidant effect and glutathione plays a main role as intracellular redox-regulating agent, we have studied for the first time the total intracellular content of homocysteine in aging. Plasma homocysteine concentration,...

journal_title：Life sciences

authors： Hernanz A,Fernández-Vivancos E,Montiel C,Vazquez JJ,Arnalich F

更新日期：2000-08-04 00:00:00

abstract：:Diltiazem, diazepam, and clonazepam effectively inhibit Na+-induced Ca2+ release from mitochondria isolated from rabbit heart and rat brain. At 10 mM NaCl, the 50% inhibition of the rate of Ca2+ release occurred at 5, 7, 40 and 350 microM of clonazepam d-cis-diltiazem, diazepam and 1-cis-diltiazem, respectively. Ro 15...

journal_title：Life sciences

authors： Matlib MA,Schwartz A

更新日期：1983-06-20 00:00:00

abstract：:The survival of osteoblast cells is one of the determinants of the development of osteoporosis in patients with inflamed synovium, such as in rheumatoid arthritis (RA). By means of alkaline phosphatase (ALP) activity and osteocalcin ELISA assay, I have shown that myricetin exhibits a significant induction of different...

journal_title：Life sciences

authors： Kuo PL

更新日期：2005-10-21 00:00:00

abstract：AIMS:The renin-angiotensin system (RAS) plays a major role in cardiovascular diseases in postmenopausal women, but little is known about its importance to lower urinary tract symptoms. In this study we have used the model of ovariectomized (OVX) estrogen-deficient rats to investigate the role of RAS in functional and m...

journal_title：Life sciences

authors： Ramos-Filho AC,A Faria J,Calmasini FB,Teixeira SA,Mónica FZ,Muscará MN,Gontijo JA,Anhê GF,Zanesco A,Antunes E

更新日期：2013-11-19 00:00:00

abstract：:The antinociceptive and temperature responses to morphine were compared in male and female rats from two different strains. Males of both the Sprague-Dawley and Wistar-Furth strains were slightly more responsive to the acute actions of morphine than were females of the same strain. However, Wistar-Furth animals requir...

journal_title：Life sciences

authors： Kasson BG,George R

更新日期：1984-04-23 00:00:00

abstract：:Plasma opioid levels were determined in 9 obese non-diabetic subjects, their 8 age matched controls, and in 29 diabetic patients; 10 maintained on diet alone, 6 on an oral hypoglycemic agent (chlorpropamide) and 13 treated with insulin. Five age matched controls for the diabetic groups were also studied for comparison...

journal_title：Life sciences

authors： Awoke S,Voyles NR,Bhathena SJ,Tanenberg RJ,Recant L

更新日期：1984-05-21 00:00:00

abstract：:We used a sensitive and specific radioimmunoassay for acetylcholine (ACh), and detected significant amounts of ACh in the blood of various mammals, including humans. About 60% of human blood ACh was localized in mononuclear leukocytes. Human leukemic T-cell lines, used as T-lymphocyte models, contained both ACh and ch...

journal_title：Life sciences

authors： Kawashima K,Fujii T,Watanabe Y,Misawa H

更新日期：1998-01-01 00:00:00

abstract：:In the early 1970's, some papers appeared reporting an immune response to opiates in animals treated with morphine and in heroin addicts, but further researches failed to confirm these results in humans. The aim of the present work is investigating with a newly developed enzyme immunoassay the existence of specific an...

journal_title：Life sciences

authors： Gamaleya N,Tagliaro F,Parshin A,Vrublevskii A,Bugari G,Dorizzi R,Ghielmi S,Marigo M

更新日期：1993-01-01 00:00:00

abstract：:The effects of a newly synthesized compound, 7-(3-[4-(2,3-dimethylphenyl)piperazinyl]propoxy)-2(1H)-quinolinone (OPC-4392), on tyrosine hydroxylation in situ and in vitro were studied using rat striatal slices and tyrosine hydroxylase (TH) purified from bovine adrenal medulla, respectively. OPC-4392 dose-dependently i...

journal_title：Life sciences

authors： Kiuchi K,Hirata Y,Minami M,Nagatsu T

更新日期：1988-01-01 00:00:00

abstract：:Green tea polyphenols like epigallocatechin gallate (EGCG) have been proposed as a cancer chemopreventative. Several studies have shown that EGCG can act as an antioxidant by trapping proxyl radicals and inhibiting lipid peroxidation. The main propose of this study is to investigate the antioxidant capacity of EGCG us...

journal_title：Life sciences

authors： Saffari Y,Sadrzadeh SM

更新日期：2004-02-06 00:00:00

abstract：AIMS:Metformin is an insulin sensitizing agent with beneficial effects in diabetic patients on glycemic levels and in the cardiovascular system. We examined whether the metabolic changes and the vascular dysfunction in monosodium glutamate-induced obese non-diabetic (MSG) rats might be improved by metformin. MAIN METH...

journal_title：Life sciences

authors： Lobato NS,Filgueira FP,Hagihara GN,Akamine EH,Pariz JR,Tostes RC,Carvalho MH,Fortes ZB

更新日期：2012-01-30 00:00:00

abstract：AIMS:Glycation of proteins leads to the formation of advanced glycation end products (AGEs, which have significant role in the pathophysiology of diabetes complications. d-ribose appears to be the most reactive among the naturally occurring sugars and contribute significantly to the generation of AGEs. Glycation also r...

journal_title：Life sciences

authors： Akhter F,Khan MS,Alatar AA,Faisal M,Ahmad S

更新日期：2016-04-15 00:00:00

abstract：:The anti-secretory activity of the competitive H2-antagonist HUK 978 was determined in rat, guinea-pig and dog. In all systems examined, HUK 978 was more potent than cimetidine and ranitidine both intravenously and orally. In addition, the compound at approximately equipotent doses as these established H2-antagonists ...

journal_title：Life sciences

authors： Coombes JD,Norris DB,Rising TJ,Ross BC,Steward A

更新日期：1985-11-04 00:00:00

abstract：:Our previous biochemical and mechanical studies have demonstrated an increase in Ca2+ sensitivity of cardiac myofilaments in ovariectomized rats. To test whether the body weight gain associated with ovariectomy contributed some effects to the changes in myofibrillar functions, the relations of pCa (-log Ca2+ molar con...

journal_title：Life sciences

authors： Wattanapermpool J,Riabroy T,Preawnim S

更新日期：2000-01-01 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. The iNOS and COX-2 proteins and their mRNA expressions in cultured vascul...

journal_title：Life sciences

authors： Hirafuji M,Tsunoda M,Machida T,Hamaue N,Endo T,Miyamoto A,Minami M

更新日期：2002-01-11 00:00:00

abstract：BACKGROUND:Cigarette smoke extract (CSE) affects the expression of non-neuronal components of cholinergic system in bronchial epithelial cells and, as PEBP1/Raf-mediated MAPK1/2 and ERK1/2 pathway, promotes inflammation and oxidative stress. AIMS:We studied whether Acetylcholine (ACh) is involved in the mechanism of c...

journal_title：Life sciences

authors： Albano GD,Bonanno A,Moscato M,Anzalone G,Di Sano C,Riccobono L,Wenzel SE,Profita M

更新日期：2018-01-01 00:00:00

abstract：:Chronic cocaine abuse has been associated with cerebrovascular pathology. This is likely to reflect its vasoactive effects; cocaine produces vasoconstriction and reduces cerebral blood flow. We propose that cerebrovascular pathology in chronic cocaine abusers would result in abnormal BOLD [blood oxygenation level depe...

journal_title：Life sciences

authors： Lee JH,Telang FW,Springer CS Jr,Volkow ND

更新日期：2003-08-29 00:00:00

abstract：:We examined the effects of cyrneine A, a novel diterpene isolated from the mushroom Sarcodon cyrneus, on morphology of rat pheochromocytoma cells (PC12). In response to cyrneine A, PC12 cells extended their neurites, an effect partially blocked by the extracellular signal-regulated kinase (ERK) kinase inhibitor PD9805...

journal_title：Life sciences

authors： Obara Y,Hoshino T,Marcotullio MC,Pagiotti R,Nakahata N

更新日期：2007-04-10 00:00:00

abstract：AIMS:Changes in cardiac autonomic nervous function have been evaluated by studying the related indexes of heart rate variability (HRV) in patients with focal epilepsy (FE) in the interictal period. MAIN METHODS:A total of 30 FE patients who were treated in our department from July 2015 to May 2017, were included into ...

journal_title：Life sciences

authors： Yu YL,Li NN,Shi MT,Lu HJ

更新日期：2018-09-15 00:00:00

abstract：AIMS:Sepsis is a major cause of morbidity and mortality in the elderly population. In prior studies, we have shown that in vivo, the inflammatory response in aged animals is exaggerated as compared to young animals and that this response likely accounts for the increased morbidity and mortality. Part of this uncontroll...

journal_title：Life sciences

authors： Leong J,Zhou M,Jacob A,Wang P

更新日期：2010-05-08 00:00:00

abstract：:beta-Adrenergic agonists used in therapy of premature labor and asthma cross the placenta and can affect development of the fetal nervous system. In the current study, pregnant rats were given 10 mg/kg of terbutaline on gestational days 17, 18 and 19 and adrenergic receptor binding capabilities examined in brain regio...

journal_title：Life sciences

authors： Slotkin TA,Kudlacz EM,Lappi SE,Tayyeb MI,Seidler FJ

更新日期：1990-01-01 00:00:00

abstract：:A wide variation in the performance of inbred rats measured in the evaluated plus maze test suggests a possible genetic basis for anxiety response (AR). To gain further insight into the role of genetics in AR, we have characterized AR in male outbred S-D rats. Rats were placed in the black compartment (BC) facing the ...

journal_title：Life sciences

authors： Prasad A,Henry M,Prasad C

更新日期：1996-01-01 00:00:00

abstract：:Further confirmation that the LHRH/LHRH agonist-induced ovulation in the hypophysectomized (hypx) rat is due to a direct ovarian effect and not mediated by LH release from residual pituitary tissue or other CNS sites is provided by the persistence of this effect despite concomitant median eminence lesion or passive im...

journal_title：Life sciences

authors： Bex FJ,Corbin A

更新日期：1984-08-27 00:00:00

abstract：:Glucocorticoid receptors (GR) are ubiquitous molecules and are present also in the hippocampus and in several other nervous and immune tissues. Peripheral blood mononuclear cells (PBMCs) are a good model for studies of GR in humans. Glucocorticoids are important for maintaining cellular and humoral homeostasis and are...

journal_title：Life sciences

authors： Grasso G,Lodi L,Lupo C,Muscettola M

更新日期：1997-01-01 00:00:00