Abstract：
:beta-Adrenergic agonists used in therapy of premature labor and asthma cross the placenta and can affect development of the fetal nervous system. In the current study, pregnant rats were given 10 mg/kg of terbutaline on gestational days 17, 18 and 19 and adrenergic receptor binding capabilities examined in brain regions of the offspring. Despite the absence of body or brain growth impairment, selective increases were seen postnatally in cerebellar alpha 1- and alpha 2-receptor subtypes, whereas the same receptor populations were decreased by small amounts in cerebral cortex and midbrain + brainstem. beta-Adrenergic receptors showed little or no change in any region. The regional and subtype selectivity are compatible with primary deficits in the development of noradrenergic projections to the cerebellum identified in previous studies and provide further evidence that therapeutic use of beta-adrenergic agonists may produce neurobehavioral teratology.
journal_name
Life Scijournal_title
Life sciencesauthors
Slotkin TA,Kudlacz EM,Lappi SE,Tayyeb MI,Seidler FJdoi
10.1016/0024-3205(90)90440-3subject
Has Abstractpub_date
1990-01-01 00:00:00pages
2051-7issue
22eissn
0024-3205issn
1879-0631pii
0024-3205(90)90440-3journal_volume
47pub_type
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