Abstract:
:The effects of various vasorelaxant agents on aortas from control and genetically diabetic rats were examined. The concentration-response curves for the isoproterenol (ISO)-induced relaxation of both aortic strips with and without endothelium are shifted to the right in diabetic rats. The relaxation responses of diabetic aorta to forskolin and vasoactive intestinal peptide did not differ from those of controls. The relaxation responses of diabetic aorta to cromakalim and nicorandil did not differ from those of controls. These results indirectly indicate that ISO-induced relaxation responses of the aortic strips from genetically diabetic rats decreased, and that this decreased relaxation response of the strips to ISO may be due to decreased density or affinity of beta adrenoceptors on the endothelium and vascular smooth muscle.
journal_name
Life Scijournal_title
Life sciencesauthors
Miyata N,Yamaura H,Tsuchida K,Otomo S,Kamata K,Kasuya Ydoi
10.1016/0024-3205(92)90287-ysubject
Has Abstractpub_date
1992-01-01 00:00:00pages
1363-9issue
18eissn
0024-3205issn
1879-0631pii
0024-3205(92)90287-Yjournal_volume
50pub_type
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