Abstract：
:The outbreak of COVID-19 in December 2019, has become an urgent and serious public health emergency. At present, there is no effective treatment or vaccine for COVID-19. Therefore, there is a crucial unmet need to develop a safe and effective treatment for COVID-19 patients. Mesenchymal stem cells (MSCs) are widely used in basic science and in a variety of clinical trials. MSCs are able to engraft to the damaged tissues after transplantation and promote tissue regeneration, besides MSCs able to secrete immunomodulatory factors that suppress the cytokine storms. Moreover, the contribution of MSCs to prevent cell death and inhibit tissue fibrosis is well established. In the current review article, the potential mechanisms by which MSCs contribute to the treatment of COVID-19 patients are highlighted. Also, current trials that evaluated the potential of MSC-based treatments for COVID-19 are briefly reviewed.
journal_name
Life Scijournal_title
Life sciencesauthors
Sadeghi S,Soudi S,Shafiee A,Hashemi SMdoi
10.1016/j.lfs.2020.118493subject
Has Abstractpub_date
2020-12-01 00:00:00pages
118493eissn
0024-3205issn
1879-0631pii
S0024-3205(20)31246-7journal_volume
262pub_type
杂志文章,评审相关文献
LIFE SCIENCES文献大全abstract：AIMS:Despite impressive survival benefits from new agents to treat metastasized prostate cancer (PCa), progressive drug resistance hinders long-term response and restricts the efficacy of subsequent therapy. Due to reported antitumor activity of amygdalin and growing popularity for complementary and alternative medicin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.01.039
更新日期：2016-02-15 00:00:00
abstract：:Morphine sulfate and other opiate/narcotic analgesics are the most effective treatments for acute and chronic severe pain. However, their clinical utility is often hampered by the development of analgesic tolerance. This complex pathophysiological cycle contributes significantly to decreased quality of life in the gro...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2009.06.011
更新日期：2010-04-10 00:00:00
abstract：AIMS:Solid lipid nanoparticles (SLNs) conjugated with surface 83-14 monoclonal antibody (8314MAb) and anti-epithelial growth factor receptor (AEGFR) were synthesized and applied to permeate the blood-brain barrier (BBB) and inhibit the growth of glioblastoma multiforme (GBM). MAIN METHODS:8314MAb and AEGFR were crossl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.01.025
更新日期：2016-02-01 00:00:00
abstract：INTRODUCTION AND AIM:Wound healing is an orderly complex process involving inflammation, clotting, re-epithelialization, neovascularization and wound closure. In diabetic patients, such process is impaired and delayed, posing negative economic as well as social consequences. Diabetex, (patency# EP 0877617 A1) composed ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.06.020
更新日期：2018-08-15 00:00:00
abstract：:There are many studies of the mechanisms of antidepressants; however, most of these studies were conducted on the hippocampus or frontal cortex. In the present study, we hypothesized that the nucleus accumbens and caudate/putamen might be major targets for antidepressant effects. Thus, we focused on G(olf) protein, a ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.01.033
更新日期：2006-06-27 00:00:00
abstract：:Protein kinase C (PKC)-dependent phosphorylation of endogenous substrates was measured in electrically permeabilised rat islets of Langerhans. The PKC-activating phorbol ester, 4 beta-phorbol myristate acetate (PMA), caused a slow but prolonged increase in insulin secretion from permeabilised islets, which was accompa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90180-w
更新日期：1992-01-01 00:00:00
abstract：:Both in men and rats, most of the ethanol ingested at a low dose is metabolized before it reaches the systemic circulation. Oxidation of ethanol (mainly in the stomach) accounts for the bulk of this effect. This "first pass" metabolism (FPM) may be viewed as a barrier which protects against the systemic toxicity of et...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90470-9
更新日期：1985-08-12 00:00:00
abstract：:In order to clarify the role played by interleukin-2 (IL-2) in the regulation of fibroblast function, we investigated the effect of rat IL-2 and human recombinant IL-2 on 3T3 fibroblast proliferation and collagen synthesis. Fibroblasts were incubated with various concentrations of IL-2 for different periods of time. I...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00125-7
更新日期：1996-01-01 00:00:00
abstract：:Using Sokoloff's 2-deoxyglucose (2-DG) autoradiographic technique, the psychotomimetic drug, phencyclidine (PCP, "angel dust") dramatically increased metabolism in diencephalic and telencephalic brain regions known to be rich in high affinity PCP receptors. These effects were greatest in the limbic circuit described i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90116-6
更新日期：1988-01-01 00:00:00
abstract：:Following a report that nortriptyline was found useful in the control of enuresis in adults, presumably as an anticholinergic, its likely mechanism of action and apparent bladder specificity have now been investigated in vitro. The ratios of anticholinergic potencies (reciprocal of dissociation contents, Ki) for four ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90093-2
更新日期：1987-05-04 00:00:00
abstract：:The aim of this study is to investigate the effect of three cucurbitacins (Cuc) E, D and I on the bilirubin-albumin binding, both in human serum albumin (HSA) and in plasma. Bilirubin-HSA solution and plasma free of cucurbitacins were prepared as well as others containing serial concentrations of cucurbitacins. The co...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.10.005
更新日期：2007-01-16 00:00:00
abstract：:The antiarrhythmic and cardioprotective drug stobadine, possessing antioxidant and neuroprotective properties, was studied as to its in vitro effect on aggregation of human blood platelets. Pretreatment of platelets with stobadine for 30 s inhibited stimulated platelet aggregation in a dose-dependent way. Depending on...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00460-9
更新日期：1999-01-01 00:00:00
abstract：:The extended infection with Helicobacter pylori (H. pylori), one of the most frequent infectious agents in humans, may cause gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. During H. pylori infection, different kinds of inflammatory cells such as dendritic cells...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2019.116688
更新日期：2019-08-15 00:00:00
abstract：:Metabolic flux through the purine salvage pathway appears to modulate superoxide secretion by elicited macrophages. Exogenous adenosine, the first substrate of this pathway, stimulates superoxide secretion, and Allopurinol, a specific inhibitor of xanthine oxidase, inhibits superoxide secretion. The effects of these a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90811-1
更新日期：1983-03-21 00:00:00
abstract：:There is a great deal of evidence that the ventromedial hypothalamic area (VMH) plays a significant role in glucoregulation. The present review synthesizes new and existing data in a coherent model of a hypothalamic glucoregulatory control system whose function is to stabilize blood glucose levels in the face of disco...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(85)90631-9
更新日期：1985-02-11 00:00:00
abstract：:Effect of mitragynine, an indole alkaloid isolated from Thai medicinal plant kratom (Mitragyna speciosa), on electrically stimulated contraction was studied in the guinea-pig ileum. Mitragynine (1 nM-3 microM) inhibited the ileum contraction elicited by electrical stimulation, and its pD2 value was 6.91 +/- 0.04 (n = ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00023-4
更新日期：1997-01-01 00:00:00
abstract：:Urine flow, osmolality, concentrations of sodium and potassium were measured every 10 min for 24 hours in 6 female dogs, whose sleep-wake stages were monitored electrographically. Experiments were conducted under hydration and progressive dehydration conditions. Visual examination and spectral analysis revealed signif...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90718-4
更新日期：1982-12-13 00:00:00
abstract：:The effect of dihydropyridine calcium channel antagonist isradipine (PN 200-110) on morphine reinforcement has been investigated using i.v. self-administration test in rats. Rats were given the opportunity to self-administer a solution of morphine (1 mg/ml, i.v.) in a 1 hr limited access paradigm (FR = 1). Within 5-7 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00397-9
更新日期：1996-01-01 00:00:00
abstract：:Thymic hormones have immunomodulatory effects on T cells and hence have been used clinically to restore the immunity of immunodeficient patients as well as to enhance the cellular immunity of cancer patients. Prothymosin alpha, which is a member of the thymic hormone family, has recently been suggested to act as a nuc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00882-5
更新日期：1997-01-01 00:00:00
abstract：:Effects of amphetamine on concentrations of dopamine, norepinephrine and serotonin in several monoamine-containing cell body and terminal regions were examined left and right separately in rats. Results suggest that amphetamine reduced the L-R asymmetry of most of these measures, and this effect is more significant in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90334-1
更新日期：1987-04-06 00:00:00
abstract：AIMS:Inducible nitric oxide synthase (iNOS) pathway has been in the limelight since its discovery as a key mediator in the process of liver fibrogenesis. Therefore, the objective of the current study was to elucidate the in vivo molecular mechanism underlying the hepatic preventive relevance of eugenol (EUG) and telmis...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.11.031
更新日期：2019-01-01 00:00:00
abstract：:S-adenosylmethionine and adenosine levels in the rat pineal gland were determined by high-performance liquid chromatography after fractionation of the pineal extracts. The concentration of S-adenosylmethionine follows a circadian rhythm and is about three times higher during the day (2.5 nmol/gland) than the night (1....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90253-4
更新日期：1984-08-06 00:00:00
abstract：:Gastric ulceration associated with the use of NSAIDs is most frequently observed in elderly women, the same sector of society most likely to be receiving therapy for osteoporosis. As some anti-osteoporosis medications have been suggested to irritate the upper gastrointestinal mucosa, we evaluated the ability of one su...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)01040-0
更新日期：1998-01-01 00:00:00
abstract：:Amino acid and reduced glutathione (GSH) levels in substantia nigra (SN) as well as striatal monoamine levels were measured in acetyl-L-carnitine (ALCar) treated and control Swiss-Webster mice. ALCar, L carnitine, or saline were administered i.p. to mice for 5 days and mice were decapitated 24 hours following the last...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90319-0
更新日期：1988-01-01 00:00:00
abstract：:3H-Flunitrazepam (FNZP) binding was examined in a crude membrane fraction obtained from rat interscapular brown adipose tissue (IBAT). A single population of binding sites was apparent with dissociation constant (KD) = 0.47 +/- 0.04 microM and maximal number of binding sites (Bmax) = 31 +/- 5 pmol.mg prot-1. From the ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90077-x
更新日期：1988-01-01 00:00:00
abstract：:Leukemias are a heterogenous group of diseases characterized by uncontrolled proliferation of abnormal blood cells of hematopoietic system. Evodiamine, a characteristic alkaloid extracted from Evodia fruits, has been reported to exhibit inhibitory effect on cell proliferation and migration in several types of cancer c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.11.025
更新日期：2004-05-21 00:00:00
abstract：:Responses to [Mpr14]-ADM(14-50), a novel analog of adrenomedullin, were investigated in the hindlimb vascular bed of the cat under conditions of controlled blood flow. Intraarterial injections of [Mpr14]-rADM(14-50) in doses of 0.003-1 nmol caused dose-related decreases in hindlimb perfusion pressure. In terms of rela...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00258-5
更新日期：1996-01-01 00:00:00
abstract：:The effects of porcine uterine fluid filtrate (PUF) on lymphocyte activity were examined. PUF was added to porcine lymphocyte cultures in the presence or absence of phytohemagglutinin (PHA), concanavalin A (Con A), or pokeweed mitogen (PWM). Lymphocyte response was determined by 3H-thymidine incorporation. Results ind...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90290-j
更新日期：1993-01-01 00:00:00
abstract：:Central dopaminergic (DA) function in children was assessed by monitoring plasma-free homovanillic acid (pHVA) levels after brief (18 hour) administration with debrisoquin sulfate, a peripherally active antihypertensive agent that blocks peripheral, but not central, HVA production. Brief debrisoquin administration res...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90239-0
更新日期：1986-03-17 00:00:00
abstract：:Systemic administration of the amphetamine analogue, 3,4-methylenedioxymethamphetamine (MDMA) produced a dose-dependent increase in the extracellular concentration of dopamine (DA) in the striatum as measured by in vivo microdialysis in awake, freely-moving rats. The extracellular concentration of the DA metabolite, 3...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90484-9
更新日期：1990-01-01 00:00:00
