Ultradian rhythms in renal excretion in dogs.

abstract：:A radioreceptor assay using [3H]nitrendipine and rat cerebral cortical membranes, in conjunction with equilibrium dialysis, measures the unbound (free) level of nitrendipine in human sera. The sensitivity of the assay is 0.1-0.2 picomoles/ml and is linear from 4 X 10(-11) to 4 X 10(-9) M nitrendipine. Other dihydropyr...

journal_title：Life sciences

authors： Lee HR,Roeske WR,Yamamura HI

更新日期：1983-10-31 00:00:00

abstract：:Hyperglycemia and/or hypoinsulinemia have been found to inhibit L-ascorbic acid cellular transport. The resultant decrease in intracellular ascorbic acid may de-inhibit aryl sulfatase B and increase degradation of sulfated glycosaminoglycans (sGAG). This could lead to a degeneration of the extracellular matrix and res...

journal_title：Life sciences

authors： Fay MJ,Bush MJ,Verlangieri AJ

更新日期：1990-01-01 00:00:00

abstract：AIMS:Despite impressive survival benefits from new agents to treat metastasized prostate cancer (PCa), progressive drug resistance hinders long-term response and restricts the efficacy of subsequent therapy. Due to reported antitumor activity of amygdalin and growing popularity for complementary and alternative medicin...

journal_title：Life sciences

authors： Makarević J,Tsaur I,Juengel E,Borgmann H,Nelson K,Thomas C,Bartsch G,Haferkamp A,Blaheta RA

更新日期：2016-02-15 00:00:00

abstract：:Evidence is provided for the abilities of endogenous 6-(Arg or Lys)-opioid peptides to interact with kappa-receptors as agonists. Dynorphin-(1-17) and -(1-8), alpha- and beta-neo-endorphin, [Met5]-enkephalin-Arg6-Phe7 and des acetyl salmon endorphin I significantly inhibited the electrically-evoked contractions of rab...

journal_title：Life sciences

authors： Oka T,Negishi K

更新日期：1982-10-18 00:00:00

abstract：AIMS:The mechanism of cough hypersensitivity induced by particulate matter 2.5 (PM2.5) remains elusive. The current study was designed to explore the effect of transient receptor potential vanilloid-1 (TRPV1) on cough hypersensitivity in airway and central nervous system. MAIN METHODS:The PM2.5-induced chronic cough m...

journal_title：Life sciences

authors： Lv H,Yue J,Chen Z,Chai S,Cao X,Zhan J,Ji Z,Zhang H,Dong R,Lai K

更新日期：2016-04-15 00:00:00

abstract：:Bupleuri radix, a traditional Chinese herb, has been widely used to treat liver diseases such as hepatitis and cirrhosis. The acetone extract of Bupleurum scorzonerifolium (AE-BS) showed a dose-dependently antiproliferative effect on the proliferation of A549 human lung cancer cells. The IC(50) of AE-BS, i.e., the con...

journal_title：Life sciences

authors： Cheng YL,Chang WL,Lee SC,Liu YG,Lin HC,Chen CJ,Yen CY,Yu DS,Lin SZ,Harn HJ

更新日期：2003-09-19 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) produces a marked pressor effect, which may be mediated by central cholinergic neurons, which in turn enhance sympathetic nervous system activity. In this study, 22 subjects (10 patients with Alzheimer's disease and 12 elderly controls) were administered IV scopolamine or placebo pr...

journal_title：Life sciences

authors： Molchan SE,Hill JL,Minichiello M,Vitiello B,Sunderland T

更新日期：1994-01-01 00:00:00

abstract：:The patterns of prolactin release after bilateral ECT and after 0.4 mg TRH i.v. were studied in 11 female melancholic patients in a 5-min sampling protocol. Mean prolactin peaking times were 10.2 min after ECT and 20.5 min after TRH. The elimination rate coefficients were significantly lower--and the corresponding hal...

journal_title：Life sciences

authors： Markianos M,Papakostas Y,Stefanis C

更新日期：1987-09-07 00:00:00

abstract：:Alzheimer's disease (AD) involves selective loss of muscarinic m2, but not m1, subtype neuroreceptors in the posterior parietal cortex of the human brain. Emission tomographic study of the loss of m2 receptors in AD is limited by the fact that there is currently no available m2-selective radioligand which can penetrat...

journal_title：Life sciences

authors： Gitler MS,Cohen VI,De la Cruz R,Boulay SF,Jin B,Zeeberg BR,Reba RC

更新日期：1993-01-01 00:00:00

abstract：AIM:Membranous nephropathy remains the most common form of the nephrotic syndrome in adults. The combination therapy of steroid and cyclophosphamide has routinely been used. Although satisfactory therapeutic efficacy can be achieved, its side effect on reproductive system has been a concern. Mizoribine is an imidazole ...

journal_title：Life sciences

authors： Wang X,Song X,Liu Y,Zhang W,An W,Tu Y

更新日期：2016-06-01 00:00:00

abstract：:The conversion of lyso-platelet activating factor (lyso-PAF) to PAF in cultured paranasal sinus mucosa obtained from normal human subjects was studied. The PAF concentration in the medium was determined after addition of lyso-PAF. PAF became detectable at 10 minutes after the addition of 10(-8)M lyso-PAF, and reached ...

journal_title：Life sciences

authors： Inoue H,Ganbo T,Hisamatsu K,Ishida H

更新日期：1993-01-01 00:00:00

abstract：AIMS:The steroid and xenobiotic receptor (SXR) regulates the transcription of its target genes by interacting with various nuclear receptor cofactors. We have previously shown that silencing mediator for retinoid and thyroid receptors (SMRT) interacts with SXR even in the presence of rifampicin on cytochrome P450 monoo...

journal_title：Life sciences

authors： Hirooka-Masui K,Lesmana R,Iwasaki T,Xu M,Hayasaka K,Haraguchi M,Takeshita A,Shimokawa N,Yamamoto K,Koibuchi N

更新日期：2013-05-20 00:00:00

abstract：:Bile duct ligation (BDL) in rats induces portal fibrosis. This process has been linked to changes in the oxidative state of the hepatic cells and in the production of nitric oxide. Our objective was to find possible temporal connections between hepatic redox state, NO synthesis and liver injury. In this work we have c...

journal_title：Life sciences

authors： Vázquez-Gil MJ,Mesonero MJ,Flores O,Criado M,Hidalgo F,Arévalo MA,Sánchez-Rodríguez A,Tuñón MJ,López-Novoa JM,Esteller A

更新日期：2004-06-25 00:00:00

abstract：:The present study investigated the protective actions of the antioxidant scutellarin against the cytotoxicity produced by exposure to H2O2 in PC12 cells. This was done by assaying for MTT (3,(4,5-dimethylthiazole-2-yl)2,5-diphenyl-tetrazolium bromide) reduction and lactate dehydrogenase (LDH) release. Reactive oxygen ...

journal_title：Life sciences

authors： Hong H,Liu GQ

更新日期：2004-04-30 00:00:00

abstract：:In view of the toxicity of cocaine and recent reports on the antimuscarinic properties of cocaine, the present study evaluated the effects of manipulations in cholinergic neurotransmission on the lethal effects of cocaine. Physostigmine pretreatment significantly altered the lethality of cocaine, increasing the LD 50 ...

journal_title：Life sciences

authors： Witkin JM,Goldberg SR,Katz JL,Kuhar MJ

更新日期：1989-01-01 00:00:00

abstract：:Hyperglycemia and oxidative stress are the primary stressors that elicit mitochondria specific cell stress in diabetes. Here we hypothesized that elevated level of ROS in high glucose (HG) environment, trigger mitochondrial stress by damaging mitochondrial DNA (mtDNA), altering inflammatory mediators, and neurodegener...

journal_title：Life sciences

authors： Pal S,Rao GN,Pal A

更新日期：2020-09-01 00:00:00

abstract：:The immunosuppressive effects of microcolin A, a lipopeptide extracted from the marine blue green alga Lyngbya majuscula were investigated. Microcolin A suppressed concanavalin A (IC50 = 5.8 nM), phytohemagglutinin (IC50 = 12.5 nM) and lipopolysaccharide (IC50 = 8.0 nM) induced proliferation of murine splenocytes. Mix...

journal_title：Life sciences

authors： Zhang LH,Longley RE,Koehn FE

更新日期：1997-01-01 00:00:00

abstract：:Previous studies demonstrated that intracerebroventricular (icv) injection of a kappa opioid receptor agonist decreased, and a mu agonist increased, body temperature (Tb) in rats. A dose-response study with the selective kappa antagonist nor-binaltorphimine (nor-BNI) showed that a low dose (1.25 nmol, icv) alone had n...

journal_title：Life sciences

authors： Chen X,McClatchy DB,Geller EB,Tallarida RJ,Adler MW

更新日期：2005-12-12 00:00:00

abstract：AIMS:This study aims to identify by a molecular genetic approach potential targets in mast cells at which 1,4-benzodiazepines may cause their inhibitory effect on mast cell activity. MAIN METHODS:Gene expression analyses with microarray gene chip and/or quantitative PCR were performed using 1,4-benzodiazepine-treated ...

journal_title：Life sciences

authors： Haenisch B,Huber M,Wilhelm T,Steffens M,Molderings GJ

更新日期：2013-03-14 00:00:00

abstract：AIMS:The aims of the present study were to investigate the effect of crebanine on memory and cognition impairment in mice and to elucidate the underlying molecular mechanisms. MAIN METHODS:The memory-enhancing effects of crebanine were assessed with a water maze test using scopolamine-induced amnesic mice. The molecul...

journal_title：Life sciences

authors： Rojsanga P,Boonyarat C,Utsintong M,Nemecz Á,Yamauchi JG,Talley TT,Olson AJ,Matsumoto K,Vajragupta O

更新日期：2012-08-21 00:00:00

abstract：:A monoclonal antibody (C351) against alpha human atrial natriuretic polypeptide (alpha hANP) recognizing human form ring structure was established and applied to a radioimmunoassay of plasma alpha hANP. The minimum detectable amount in terms of 10% radioligand displacement relative to zero dose were 0.28 fmol/tube, co...

journal_title：Life sciences

authors： Naomi S,Umeda T,Iwaoka T,Miura F,Ohno M,Sasaki M,Oishi S,Sato T,Takatsu K

更新日期：1988-01-01 00:00:00

abstract：:In order to explore the effect of neonatal androgen administration on oocyte quality, ovulation induction and in vitro fertilization (IVF) were performed in androgen-sterilized mice. Androgen sterilized mice were produced by the subcutaneous injection of testosterone propionate (TP) at 5 days of age and ovulation indu...

journal_title：Life sciences

authors： Kamijo T,Mizunuma H,Yamada K,Ibuki Y

更新日期：1994-01-01 00:00:00

abstract：:Individuals have an inherent capacity to cope with stressors in the form of stress adaptation. Apart from stress adaptation there is another well documented phenomenon known as cross stress adaptation. In this, there is a reduction in stress responsiveness to a novel stressor (in which the adapted organism had never e...

journal_title：Life sciences

authors： Chauhan E,Bali A,Singh N,Jaggi AS

更新日期：2015-09-15 00:00:00

abstract：:Protein binding determination in post heparin plasma samples is complicated by the continued post heparin lipase activity, in vitro, during the binding analysis. The decomposition of lipoproteins and accumulation of nonesterified fatty acids (NEFA) results in artifically elevated free fractions of many drugs. This art...

journal_title：Life sciences

authors： Pearce GA,Brown KF

更新日期：1983-10-10 00:00:00

abstract：:Chymase is an important enzyme for the generation of angiotensin (Ang) II and in the activation of transforming growth factor (TGF)-beta1. Therefore, chymase may be involved in the hemodialysis access dysfunction, which is caused by intimal hyperplasia that occurs after polytetrafluoroethylene (PTFE) graft implantatio...

journal_title：Life sciences

authors： Jin D,Ueda H,Takai S,Muramatsu M,Furubayashi K,Ibaraki T,Kishi K,Katsuoka Y,Miyazaki M

更新日期：2007-09-29 00:00:00

abstract：AIMS:We performed a systematic review and meta-analysis on the effect of HIV infection and antiretroviral therapy (ART) on carotid intima-media thickness (cIMT) to elucidate the role of HIV infection and ART. Also, an analysis on the role of ethnicity and gender on cIMT in HIV-infected populations was performed. MAIN ...

journal_title：Life sciences

authors： Msoka TF,Van Guilder GP,van Furth M,Smulders Y,Meek SJ,Bartlett JA,Vissoci JRN,van Agtmael MA

更新日期：2019-10-15 00:00:00

abstract：:Ischemic preconditioning (IP) may protect the lung from ischemia-reperfusion (I/R) injury following cardiopulmonary by-pass and lung or heart transplantation. The present study was undertaken to investigate the role of ATP-dependent potassium channels (K(ATP)) in IP in the isolated buffer-perfused rat lung (IBPR) unde...

journal_title：Life sciences

authors： Kandilci HB,Gümüşel B,Demiryürek AT,Lippton H

更新日期：2006-11-02 00:00:00

abstract：:The drug transporter, multidrug resistance-associated protein 2 (ABCC2/Mrp2), is known to play important roles in excretion of various drugs. In the present study, we investigated whether Mrp2 is involved in the transport of micafungin, a newly developed antifungal agent. When Sprague-Dawley rats received an intraveno...

journal_title：Life sciences

authors： Abe F,Ueyama J,Kimata A,Kato M,Hayashi T,Nadai M,Saito H,Takeyama N,Noguchi H,Hasegawa T

更新日期：2008-08-15 00:00:00

abstract：AIMS:In this study, we conducted a meta-analysis to systematically compare the diagnostic accuracy of IGRAs performed for extrasanguinous body fluids with that performed for blood in the diagnosis of TB. MAIN METHODS:Multiple English and Chinese databases were searched up to November 2017. Studies that complied with t...

journal_title：Life sciences

authors： Wen A,Qu XH,Zhang KN,Leng EL,Ren Y,Wu XM

更新日期：2018-03-15 00:00:00

abstract：:Lewis rats were trained to self-stimulate the medial forebrain bundle (MFB) using a rate-frequency paradigm. They were then tested for the effects of the cannabinoid receptor agonist CP 55,940, the selective cannabinoid receptor antagonist SR 141716 and the dopamine D1 receptor antagonist SCH 23390. CP 55,940 (0, 10, ...

journal_title：Life sciences

authors： Arnold JC,Hunt GE,McGregor IS

更新日期：2001-11-21 00:00:00