Abstract:
:Previous studies demonstrated that intracerebroventricular (icv) injection of a kappa opioid receptor agonist decreased, and a mu agonist increased, body temperature (Tb) in rats. A dose-response study with the selective kappa antagonist nor-binaltorphimine (nor-BNI) showed that a low dose (1.25 nmol, icv) alone had no effect, although a high dose (25 nmol, icv) increased Tb. It was hypothesized that the hyperthermia induced by nor-BNI was the result of the antagonist blocking the kappa opioid receptor and releasing its inhibition of mu opioid receptor activity. To determine whether the Tb increase caused by nor-BNI was a mu receptor-mediated effect, we administered the selective mu antagonist CTAP (1.25 nmol, icv) 15 min after nor-BNI (25 nmol, icv) and measured rectal Tb in unrestrained rats. CTAP significantly antagonized the Tb increase induced by icv injection of nor-BNI. Injection of 5 or 10 nmol of CTAP alone significantly decreased the Tb, and 1.25 nmol of nor-BNI blocked that effect, indicating that the CTAP-induced hypothermia was kappa-mediated. The findings strongly suggest that mu antagonists, in blocking the basal hyperthermia mediated by mu receptors, can unmask the endogenous kappa receptor-mediated hypothermia, and that there is a tonic balance between mu and kappa opioid receptors that serves as a homeostatic mechanism for maintaining Tb.
journal_name
Life Scijournal_title
Life sciencesauthors
Chen X,McClatchy DB,Geller EB,Tallarida RJ,Adler MWdoi
10.1016/j.lfs.2005.04.084subject
Has Abstractpub_date
2005-12-12 00:00:00pages
329-33issue
4eissn
0024-3205issn
1879-0631pii
S0024-3205(05)00977-Xjournal_volume
78pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::The mechanism for the development of insulin resistance in normal pregnancy is complex and is associated with serum levels of sex hormones. However, the influence of these hormones on the early steps of insulin action has not been extensively studied, although the potentially beneficial effect of estradiol on glucose ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01489-3
更新日期:2002-02-22 00:00:00
abstract::To study the effects of volume overload and renal failure on plasma levels of immunoreactive atrial natriuretic hormone (IR-ANH), we measured levels of this hormone in normal subjects, in patients with advanced chronic renal failure (CRF) with and without clinically evident volume overload, and in patients with end-st...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90732-6
更新日期:1987-09-28 00:00:00
abstract::This study analyses possible changes during surgical and chemical castration in the expression and pharmacological characteristics of alpha1-adrenoceptor in adult rat seminal vesicle. Ribonuclease protection assays indicated that alpha1a--was the predominant mRNA, while alpha1b-and alpha1d-adrenoceptor transcripts wer...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.03.011
更新日期:2004-08-06 00:00:00
abstract::Chronic cocaine abuse has been associated with cerebrovascular pathology. This is likely to reflect its vasoactive effects; cocaine produces vasoconstriction and reduces cerebral blood flow. We propose that cerebrovascular pathology in chronic cocaine abusers would result in abnormal BOLD [blood oxygenation level depe...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00548-4
更新日期:2003-08-29 00:00:00
abstract::Renal handling of the aminoglycoside antibiotics gentamicin and tobramycin were studied before and after one hour of constant intravenous infusions adjusted to maintain a concentration of 15 micrograms/mL. A solitary renal autotransplant model in four conscious volume replete 40 Kg sheep was used. This unique surgical...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90032-2
更新日期:1983-01-17 00:00:00
abstract::Dehydroepiandrosterone (DHEA), the major secretory product of the human adrenal cortex, significantly declines with advanced age. We have previously demonstrated that DHEA prevents the reduction in non-amyloidogenic APP processing, following prolonged stimulation of the muscarinic receptor, in PC12 cells that express ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00496-1
更新日期:1996-01-01 00:00:00
abstract::The cellular electrophysiology of left ventricular preparations from guinea pig hearts was studied 1 hour, 24 hours, and 4-6 weeks after myocardial infarction produced by 6-8 single ties of the distal left coronary artery system or after sham operation. Microelectrode recordings were used to monitor cells from the end...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90343-1
更新日期:1985-06-24 00:00:00
abstract::The metabolism of haloperidol (HP) to the potentially neurotoxic pyridinium species, HPP+ and RHPP+, has been demonstrated in humans. In vitro studies in microsomes harvested from various animal species indicate that the tetrahydropyridines, HPTP and RHPTP, could be intermediates in this pathway. However, this has not...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00955-7
更新日期:1997-01-01 00:00:00
abstract:AIMS:Interleukin-1β (IL-1β) is a cytokine that is known to activate the stress axis and suppress the reproductive axis. Different brain areas are involved in the regulation of these two axes. However, they are both under the stimulatory control of the catecholamine, norepinephrine (NE). Here, we hypothesized that IL-1β...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.09.004
更新日期:2012-10-29 00:00:00
abstract::The effects of denervation of alpha 2 adrenoceptor binding sites were examined in canine arteries and veins. Denervation of the lower abdominal aorta, renal and femoral arteries and femoral veins marked reduced vessel norepinephrine concentrations. Denervation had little effect on the concentration of alpha 2 adrenoce...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(83)80005-8
更新日期:1983-07-25 00:00:00
abstract::The conversion of lyso-platelet activating factor (lyso-PAF) to PAF in cultured paranasal sinus mucosa obtained from normal human subjects was studied. The PAF concentration in the medium was determined after addition of lyso-PAF. PAF became detectable at 10 minutes after the addition of 10(-8)M lyso-PAF, and reached ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90483-j
更新日期:1993-01-01 00:00:00
abstract:AIMS:Obesity represents a global health problem. Excessive caloric intake promotes the release of inflammatory mediators by hypertrophic adipocytes and obesity-induced inflammation is now recognized as a risk factor for the development of several diseases, such as cardiovascular diseases, insulin resistance, type-II di...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118618
更新日期:2021-01-01 00:00:00
abstract::Our previous biochemical and mechanical studies have demonstrated an increase in Ca2+ sensitivity of cardiac myofilaments in ovariectomized rats. To test whether the body weight gain associated with ovariectomy contributed some effects to the changes in myofibrillar functions, the relations of pCa (-log Ca2+ molar con...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00623-2
更新日期:2000-01-01 00:00:00
abstract::The use of neuroleptic drugs to treat schizophrenia is almost invariably associated with extrapyramidal movement disorders. One of these disorders, tardive dyskinesia (TD), can persist long after neuroleptic withdrawal suggesting that permanent neurological damage is produced. However, there appears to be no convincin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00442-2
更新日期:2000-02-25 00:00:00
abstract:AIMS:This study aims to evaluate the relationship between the amount of physical activity and different traditional and novel cardiometabolic risk factors, as well as atheroprotective agents, in male children and adolescents. MAIN METHODS:Cross-sectional study. A total of 337 male children and adolescents aged 7-14 ye...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.05.021
更新日期:2013-07-30 00:00:00
abstract:AIMS:The study aimed to investigate the protective effect of chronic intermittent hypobaric hypoxia (CIHH) on endothelium function and relaxation of mesenteric artery in metabolism syndrome (MS) rats. MAIN METHODS:Male adult Sprague-Dawley rats were randomly divided into control (CON), CIHH (treated with 28-days hypob...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.05.008
更新日期:2018-07-15 00:00:00
abstract::Amyloid beta protein (Abeta) alters signal transduction systems, including increases in the cytosolic free calcium ([Ca2+]i) response which have pathophysiological significance in Alzheimer's disease (AD). The purposes of this study were to elucidate the mechanism involved in Abeta's effect on the Ca2+ signal and to e...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00470-7
更新日期:2000-01-01 00:00:00
abstract::This study in conscious normotensive rats was performed to assess the effect of the vasoconstrictor peptide, neuropeptide Y (NPY), on blood pressure responsiveness to exogenous norepinephrine in endotoxaemia. NPY and endotoxin were infused at doses which had no effect on blood pressure, whether given alone or in combi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90442-5
更新日期:1987-12-07 00:00:00
abstract::We investigated the involvement of alpha 1-adrenoceptor subtypes in the positive chronotropic response to norepinephrine (NE) in neonatal rat cardiac myocytes at day 3 of culture. The cardiac myocytes at day 3 of culture exhibited a dose-dependent positive chronotropic response to NE in the presence of propranolol, a ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)90155-4
更新日期:1994-01-01 00:00:00
abstract::Previous in vitro evidence suggests that adrenaline causes K influx in skeletal muscle by stimulating a ouabain sensitive Na/K ATPase membrane pump. However in rabbits, adrenaline induced hypokalaemia was not significantly altered by pretreatment with digoxin (50 micrograms/kg). Rats were infused with adrenaline or sa...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90258-x
更新日期:1987-01-05 00:00:00
abstract::The traditional Chinese medicines have been used clinically for a long time in some Asian countries, however, very few studies have been done to demonstrate the working mechanisms of these medicines using recently developed biochemical methodologies. In this study, we examined the anti-inflammatory effect of Huang-Lia...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00557-3
更新日期:2000-01-01 00:00:00
abstract::Tiazofurin and retinoic acid synergistically induced differentiation and inhibited colony formation in HL-60 human promyelocytic leukemia cells in cell culture. The synergism was the result of different mechanisms of action, since the effect of tiazofurin, unlike that of retinoic acid, was prevented by addition of gua...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90087-8
更新日期:1990-01-01 00:00:00
abstract::Ro41-0960 is a potent, fluorine containing COMT inhibitor which has be en reported to cross the blood brain barrier and to inhibit COMT in the brain. It is structurally similar to Ro40-7592 which is currently undergoing clinical trials in Parkinson's disease. Positron emission tomographic (PET) studies in baboon using...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)02277-5
更新日期:1996-01-01 00:00:00
abstract::Previous research has shown that the CAMK (calcium/calmodulin dependent protein kinase) inhibitor, KN62, can lead to reductions in insulin stimulated glucose transport. Although controversial, an L-type calcium channel mechanism has also been hypothesized to be involved in insulin stimulated glucose transport. The pur...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.06.041
更新日期:2004-01-02 00:00:00
abstract::Autophagy is an essential cellular mechanism which plays "housekeeping" role in normal physiological processes including removing of long lived, aggregated and misfolded proteins, clearing damaged organelles, growth regulation and aging. Autophagy is also involved in a variety of biological functions like development,...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2017.08.029
更新日期:2017-11-01 00:00:00
abstract::Biliary excretion is the main route of disposal of bilirubin and impaired excretion results in jaundice, a well recognisable symptom of liver disease. Conjugation of bilirubin in the liver is essential for its clearance. The glucuronidation of bilirubin is catalysed by the microsomal UDP-glucuronosyltransferase UGT1A1...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.08.018
更新日期:2006-03-06 00:00:00
abstract::Bacterial endotoxin or lipopolysaccharide (LPS) can trigger inflammatory responses and cause damage in organs such as liver and lungs when it is introduced into mammals, but the exact molecular events that mediate these responses have remained obscure. In this study, by using 2D gel electrophoresis and cDNA microarray...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.06.018
更新日期:2006-10-04 00:00:00
abstract::The effects of longer lasting blood pressure changes on the release of endogenous catecholamines (CA) in limbic and hypothalamic areas were studied in anaesthetized rats. For this purpose the central nucleus of the amygdala (AC), ventral hippocampus (VH) and medial hypothalamus (MH) were simultaneously superfused thro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90496-6
更新日期:1987-07-13 00:00:00
abstract::The beta adrenoceptor antagonist radioligand [3H] dihydroalprenolol (DHA) has been used to characterise beta adrenoceptors in membranes prepared from rat renal glomeruli. Association of the ligand was rapid and had reached equilibrium within 10 mins at 37 degrees C. Dissociation occurred in two distinct phases, a rapi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90715-4
更新日期:1983-07-04 00:00:00
abstract::The effect of the synthetic amino-terminal fragment of bovine parathyroid hormone, bPTH-(1-34), on the adenylate cyclase of microvessels and glomeruli isolated from rabbit kidney cortex was studied in the presence and absence of guanosine triphosphate (GTP). bPTH-(1-34) stimulated the vascular and glomerular adenylate...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90034-1
更新日期:1984-12-24 00:00:00