Abstract：
:This study in conscious normotensive rats was performed to assess the effect of the vasoconstrictor peptide, neuropeptide Y (NPY), on blood pressure responsiveness to exogenous norepinephrine in endotoxaemia. NPY and endotoxin were infused at doses which had no effect on blood pressure, whether given alone or in combination. Endotoxin markedly reduced the pressor responses to bolus injections of norepinephrine. However, blood pressure responsiveness could be enhanced by infusing NPY simultaneously with the endotoxin. It is suggested that low dose NPY infusions may be clinically useful in reversing the reduced vascular responsiveness to pressor amines in shock.
journal_name
Life Scijournal_title
Life sciencesauthors
Evéquoz D,Waeber B,Corder R,Nussberger J,Gaillard R,Brunner HRdoi
10.1016/0024-3205(87)90442-5subject
Has Abstractpub_date
1987-12-07 00:00:00pages
2573-80issue
23eissn
0024-3205issn
1879-0631pii
0024-3205(87)90442-5journal_volume
41pub_type
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