Abstract:
:Tiazofurin and retinoic acid synergistically induced differentiation and inhibited colony formation in HL-60 human promyelocytic leukemia cells in cell culture. The synergism was the result of different mechanisms of action, since the effect of tiazofurin, unlike that of retinoic acid, was prevented by addition of guanosine. Since it has been shown that tiazofurin down-regulated the expression of c-Ki-ras oncogene, and retinoic acid that of the myc oncogene, the joint impact of these drugs is of clinical interest particularly in end-stage leukemia where the therapeutic usefulness of tiazofurin has recently been demonstrated.
journal_name
Life Scijournal_title
Life sciencesauthors
Yamaji Y,Natsumeda Y,Yamada Y,Irino S,Weber Gdoi
10.1016/0024-3205(90)90087-8subject
Has Abstractpub_date
1990-01-01 00:00:00pages
435-42issue
6eissn
0024-3205issn
1879-0631pii
0024-3205(90)90087-8journal_volume
46pub_type
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