当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Interaction of silencing mediator for retinoid and thyroid receptors with steroid and xenobiotic receptor on multidrug resistance 1 promoter.

Interaction of silencing mediator for retinoid and thyroid receptors with steroid and xenobiotic receptor on multidrug resistance 1 promoter.

Abstract：

AIMS:The steroid and xenobiotic receptor (SXR) regulates the transcription of its target genes by interacting with various nuclear receptor cofactors. We have previously shown that silencing mediator for retinoid and thyroid receptors (SMRT) interacts with SXR even in the presence of rifampicin on cytochrome P450 monooxygenase 3A4 (CYP3A4) promoter in HepG2 cells. To examine the specificity of such interaction, the involvement of SMRT on SXR-mediated transcription through multidrug resistance (MDR) 1 gene promoter was examined using LS174T intestine-derived clonal cells. MAIN METHODS:Transient transfection-based reporter gene assay was carried out to examine the effect of SMRT or nuclear receptor corepressor (NCoR) on SXR-mediated transcription in LS174T cells. Semi-quantitative RT-PCR was performed to confirm the expression of MDR1 mRNA in LS174T cells. To examine the interaction of SMRT with SXR, we carried out mammalian one-hybrid assay in CV-1 cells and immunoprecipitation study in HEK-293 cells. KEY FINDINGS:SMRT, but not NCoR suppressed rifampicin-induced SXR-mediated transcription. The SXR-mediated MDR1 mRNA expression was augmented in the presence of rifampicin, whereas it suppressed the expression following the overexpression of SMRT. In mammalian one-hybrid assay, only SMRT but not NCoR interacted with SXR on MDR1 promoter in the presence of rifampicin. In immunoprecipitation study, SMRT bound to SXR regardless of the presence or absence of rifampicin. SIGNIFICANCE:SMRT may be recruited in the SXR-cofactor complex even in the presence of ligand. SMRT may be involved not only in SXR-mediated suppression without ligand, but also in ligand-activated transcription to suppress the overactivation of transcription.

journal_name

Life Sci

journal_title

Life sciences

authors

Hirooka-Masui K,Lesmana R,Iwasaki T,Xu M,Hayasaka K,Haraguchi M,Takeshita A,Shimokawa N,Yamamoto K,Koibuchi N

doi

10.1016/j.lfs.2013.03.007

subject

Has Abstract

pub_date

2013-05-20 00:00:00

pages

911-5

issue

17-19

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(13)00175-6

journal_volume

92

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Evidence that a mitogen-inducible prolactin-immunoreactive protein in rat spleen lymphocytes is aldolase A.

    abstract：:This study characterizes several proteins in rat spleen lymphocyte lysates and conditioned medium that are recognized by antiserum to purified rat pituitary prolactin (PRL). One of these proteins, rat prolactin-immunoreactive protein (rPIP-43), has a relative molecular mass (Mr) of 43,000 and is strongly induced by mi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00232-4

    authors： Masten SA,Shiverick KT

    更新日期：1997-01-01 00:00:00

  • Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii.

    abstract：:Herba Epimedii is an important medicinal plant which has been used in various traditional Chinese formulations for thousands of years as well as in modern proprietary traditional Chinese medicine products. It has extensive clinical indications, especially for the treatment of sexual dysfunction and osteoporosis. There...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2015.01.006

    authors： Li C,Li Q,Mei Q,Lu T

    更新日期：2015-04-01 00:00:00

  • Chronic treatment with antidepressants, verapamil, or lithium inhibits the serotonin-induced intracellular calcium response in individual C6 rat glioma cells.

    abstract：:The effects of chronic treatment with antidepressants, verapamil, or lithium on serotonin (5-HT)-induced Ca2+ increase were investigated in single C6BU-1 glioma cells with digital imaging microscopy. Clomipramine and citalopram, at a concentration of 100 nM, decreased the peak values of 5-HT-induced [Ca2+]i changes. V...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00010-6

    authors： Yamaji T,Kagaya A,Uchitomi Y,Yokota N,Yamawaki S

    更新日期：1997-01-01 00:00:00

  • The effect of steroids on the size heterogeneity of pituitary prolactin in castrate male rats.

    abstract：:Male Sprague-Dawley rats were castrated and given daily sc. injections of estradiol (E2, 10 micrograms/day), testosterone propionate (TP, 1.0 mg/day), dihydrotestosterone (DHT, 1.0 mg/day) or sesame oil (SO, 0.2 ml/day). A group of sham castrate males received daily sc. injections of SO (0.2 ml/day). On day 8 of stero...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90327-8

    authors： Haisenleder DJ,Lawson DM,Gala RR

    更新日期：1984-01-02 00:00:00

  • Magnesium ion: a possible physiological regulator of aldosterone production.

    abstract：:We examined the direct effect of magnesium ion on aldosterone production by adrenal cells using collagenase-dispersed zona-glomerulosa cells in rats. The effects of magnesium on aldosterone production stimulated by angiotensin II or ACTH were also investigated. Both magnesium sulphate (MgSO4) and magnesium chloride (M...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90327-5

    authors： Atarashi K,Matsuoka H,Takagi M,Sugimoto T

    更新日期：1989-01-01 00:00:00

  • Surgical and pharmacological reductions in sympathetic nerve activity increase the neuropeptide Y-immunoreactivity content of the rat iris but not the vas deferens.

    abstract：:Decentralization of the superior cervical ganglion (S.C.G.) of the rat elevated the neuropeptide-Y immunoreactivity (NPY-ir) content of the ganglion on day 1 (+43%) but not on day 3 post-surgery. The content of NPY-ir in the iris was increased by decentralization (+40%) 3 days post-surgery, and treatment with clonidin...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(88)90333-5

    authors： Maccarrone C,Jarrott B

    更新日期：1988-01-01 00:00:00

  • Specific ganglioside binding to receptor sites on T lymphocytes that couple to ganglioside-induced decrease of CD4 expression.

    abstract：:The binding of different gangliosides to rat T-helper lymphocytes was characterized under conditions that decrease CD4 expression on different mammalian T-helper lymphocytes. Saturation binding by monosialylated [3H]-GM1 to rat T-lymphocytes was time- and temperature-dependent, had a dissociation constant (KD) of 2.2 ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90123-9

    authors： Morrison WJ,Offner H,Vandenbark AA

    更新日期：1989-01-01 00:00:00

  • Development of a model for Parkinson's disease in sheep using unilateral intracarotid injection of MPTP via slow continuous infusion.

    abstract：:The effects of unilateral intracarotid administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in sheep were studied with the goal of producing a non-primate, large animal model of Parkinson's Disease. Adult female sheep were given an acute (over 30 min) or chronic (over 1 week) injection of MPTP (0.4-5....

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)00406-4

    authors： Baskin DS,Browning JL,Widmayer MA,Zhu ZQ,Grossman RG

    更新日期：1994-01-01 00:00:00

  • Action of phosphatidylinositol specific phospholipase C on platelets: nonlytic release of acetylcholinesterase, effect on thrombin and PAF induced aggregation.

    abstract：:Phosphatidylinositol (PI) specific phospholipase C treatment of rabbit platelets caused 95% release of acetylcholinesterase in the supernatant and 4 to 6% hydrolysis of membrane PI in 2 min. Under these conditions there was no cell lysis as monitored by lack of lactate dehydrogenase activity in the medium. The phospho...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90590-4

    authors： Shukla SD

    更新日期：1986-02-24 00:00:00

  • The organ distribution of liposome-encapsulated and free cobalt in rats. Liposomes decrease the cardiac uptake of the metal.

    abstract：:Rats were administered intravenously liposome-encapsulated or free cobalt, and the organ distribution of the metal was explored using Co57 tracer. Two hours after administration, the cobalt level in the heart was about 40% of the control when given in sphingomyelin (SM)/cholesterol (CH) (1:1 mole ratio) liposomes. The...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90092-1

    authors： Szebeni J,Garcia R,Eskelson CD,Chvapil M

    更新日期：1989-01-01 00:00:00

  • Suppression of neuropeptides' mRNA expression by herbal medicines in a rat model of peripheral inflammation.

    abstract：:The traditional Chinese medicines have been used clinically for a long time in some Asian countries, however, very few studies have been done to demonstrate the working mechanisms of these medicines using recently developed biochemical methodologies. In this study, we examined the anti-inflammatory effect of Huang-Lia...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00557-3

    authors： Dai Y,Miki K,Fukuoka T,Tokunaga A,Tachibana T,Kondo E,Noguchi K

    更新日期：2000-01-01 00:00:00

  • Apoptosis-like cell death of human breast cancer cell line MCF-7 induced by buprenorphine hydrochloride.

    abstract：:The analgesic buprenorphine hydrochloride (Bph) induced apoptosis-like cell death in the caspase-3-deficient human breast cancer cell line, MCF-7. This apoptosis-like cell death activated key molecules in the mitochondrial apoptotic pathway: cytochrome c, caspase-9, caspase-7, and caspase-6. Bph caused the release of ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2003.11.032

    authors： Kugawa F,Matsumoto K,Aoki M

    更新日期：2004-06-04 00:00:00

  • Mechanisms of preserved baseline cardiac systolic function in rats with adrenergic inotropic downregulation.

    abstract：:Despite reductions in beta-adrenoreceptor (beta-AR)-mediated inotropic effects induced by sustained sympathetic activation in cardiac disease, whether these changes necessarily result in reductions in systolic function under resting conditions (baseline function) is not clear. Moreover, possible compensatory mechanism...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.04.047

    authors： Osadchii O,Woodiwiss A,Alves N,Norton G

    更新日期：2005-12-12 00:00:00

  • Nicotine depresses the functions of multiple cardiac potassium channels.

    abstract：:Nicotine is the main constituent of tobacco smoke responsible for the elevated risk of the cardiovascular disease and sudden coronary death associated with smoking, presumably by provoking cardiac arrhythmias. The cellular mechanisms may be related to the ability of nicotine to prolong action potentials and to depolar...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00370-7

    authors： Wang H,Shi H,Wang Z

    更新日期：1999-01-01 00:00:00

  • Non-neuronal expression of choline acetyltransferase in the rat kidney.

    abstract：AIMS:Acetylcholine (ACh) has been shown to increase ion and water excretion in the kidneys, resulting in hypotension. However, no evidence of renal parasympathetic innervation has been shown, and the source of ACh acting on nephrons is still unknown. The aim of the present study was to identify ACh-producing cells in t...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2011.07.011

    authors： Maeda S,Jun JG,Kuwahara-Otani S,Tanaka K,Hayakawa T,Seki M

    更新日期：2011-09-12 00:00:00

  • The effects of flavonoids on human phenolsulphotransferases: potential in drug metabolism and chemoprevention.

    abstract：:Flavonoids are frequently found in fruits and vegetables, and are currently under investigation as potential chemopreventive agents. The present study reports the inhibitory effects of six flavonoids, quercetin, genistein, daidzein, equol, (+)-catechin and flavone, on sulphation of p-nitrophenol, a model substrate for...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00423-3

    authors： Ghazali RA,Waring RH

    更新日期：1999-01-01 00:00:00

  • In vivo and in vitro effect of naloxone on prolactin response to TRH in rat.

    abstract：:In adult male Wistar rats submitted to a standardized noise stress, intravenous TRH induced a prolactin (PRL) secretory response. Prior IV naloxone administration not only lowered plasma PRL levels in those stressed rats but abolished also the stimulatory action of TRH. This effect was further studied by superfusion e...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90756-9

    authors： Velkeniers B,Buydens P,Baldys A,De Boel S,Finné E,Golstein J,Vanhaelst L

    更新日期：1987-06-22 00:00:00

  • Molecular mechanisms of interplay between autophagy and metabolism in cancer.

    abstract：:Autophagy is an essential mechanism of cellular degradation, a way to protect the cells under stress conditions, such as deprivation of nutrients, growth factors and cellular damage. However, in normal physiology autophagy plays a significant role in cancer cells. Current research is in progress to understand how auto...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2020.118184

    authors： Raj S,Chandel V,Kumar A,Kesari KK,Asthana S,Ruokolainen J,Kamal MA,Kumar D

    更新日期：2020-10-15 00:00:00

  • Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism.

    abstract：AIMS:Endothelial dysfunction is a key triggering event in the development of cardiovascular diseases and the current study explored this phenomenon in the context of inflammation, apoptosis, reactive oxygen species (ROS) and the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway during chronic diabetes. MAIN M...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2010.03.019

    authors： Bitar MS,Ayed AK,Abdel-Halim SM,Isenovic ER,Al-Mulla F

    更新日期：2010-06-05 00:00:00

  • Dopamine receptor mRNAs in the rat lymphocytes.

    abstract：:It has been suggested that dopamine might play a role in the regulation of the immune system. In this study, reverse transcriptase-polymerase chain reaction (RT-PCR) was used to investigate the expression of mRNA for the different subtypes of dopamine receptors in the rat lymphocytes. D1, D3 and D5 receptor mRNAs were...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00160-x

    authors： Caronti B,Calderaro C,Passarelli F,Palladini G,Pontieri FE

    更新日期：1998-01-01 00:00:00

  • Antenatal glucocorticoid therapy increase cardiac alpha-enolase levels in fetus and neonate rats.

    abstract：AIMS:Antenatal glucocorticoid therapy has been shown to prevent acute diseases including infant respiratory distress syndrome and reduce mortality, although little is known about the effects on cardiac function-related proteins in the fetus or neonate. We investigated whether cardiac function-related proteins were alte...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2009.06.017

    authors： Tsuzuki Y,Takeba Y,Kumai T,Matsumoto N,Mizuno M,Murano K,Asoh K,Takagi M,Yamamoto H,Kobayashi S

    更新日期：2009-10-21 00:00:00

  • Unpredictable cold-immobilization stress effects on voluntary ethanol consumption in rats.

    abstract：:The effects of exposure to a schedule of unpredictable cold-immobilization stress on voluntary ethanol consumption were examined. Following testing for ethanol preference, rats were divided into high, medium and low ethanol consuming groups on the basis of daily ethanol intake (g/kg/day) and exposed to immobilization ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90580-7

    authors： Rockman GE,Hall A,Hong J,Glavin GB

    更新日期：1987-03-30 00:00:00

  • Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors.

    abstract：:The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible ...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0024-3205(99)00282-9

    authors： Pertwee RG

    更新日期：1999-01-01 00:00:00

  • Long-lasting blockade of P2-receptors of the urinary bladder in vivo following photolysis of arylazido aminopropionyl ATP, a photoaffinity label.

    abstract：:In the present study the possibility of provoking an irreversible blockade of P2-receptors in vivo by photolyzing ANAPP3 was investigated. ANAPP3 administered as an intraarterial infusion produced a short-lived blockade of P2-receptor mediated contractions of cat urinary bladders in situ. However, irradiation of the b...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90498-4

    authors： Theobald RJ Jr,Hoffman V

    更新日期：1986-04-28 00:00:00

  • The role of charge interactions in muscarinic agonist binding, and receptor-response coupling.

    abstract：:Site-directed mutagenesis has been used to evaluate the roles of the key aspartate and arginine residues in transmembrane domain three of the muscarinic receptors. The results suggest that the formation of an ionic bond between the Asp carboxylate group and the onium headgroup is essential to anchor acetylcholine in i...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)00025-2

    authors： Hulme EC,Curtis CA,Page KM,Jones PG

    更新日期：1995-01-01 00:00:00

  • Bile duct ligation promotes covalent drug-protein adduct formation in plasma but not in liver of rats given zomepirac.

    abstract：:Acyl glucuronides are reactive electrophilic metabolites of carboxylate drugs, capable of undergoing hydrolysis, rearrangement and covalent binding reactions with proteins in vivo. Such covalent drug-protein adducts may be prerequisites for certain idiosyncratic immune and toxic responses in susceptible individuals. T...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)00958-9

    authors： Wang M,Dickinson RG

    更新日期：2000-12-22 00:00:00

  • The NMDA antagonist dizocilpine (MK801) attenuates motivational as well as somatic aspects of naloxone precipitated opioid withdrawal.

    abstract：:The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine has recently been reported to antagonize certain overt withdrawal signs in morphine dependent rats. The purpose of the present study was to reassess this response and examine the effect of this drug in a model presumably reflective of the ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90452-u

    authors： Higgins GA,Nguyen P,Sellers EM

    更新日期：1992-01-01 00:00:00

  • miRNA-150-5p associate with antihypertensive effect of epigallocatechin-3-gallate revealed by aorta miRNome analysis of spontaneously hypertensive rat.

    abstract：AIMS:The antihypertensive mechanism (s) of the epigallocatechin-3-gallate (EGCG), a major effective component in green tea, might associate with microRNAs (miRNAs). Here, we aimed to investigate which microRNA in aorta of spontaneously hypertensive rats (SHRs) were modulated by administration of EGCG and its mechanism....

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.04.041

    authors： Qian BJ,Tian CC,Ling XH,Yu LL,Ding FY,Huo JH,Zhu LC,Wen YL,Zhang JH,Jing P

    更新日期：2018-06-15 00:00:00

  • Visualization by positron emission tomography of the apparent regional heterogeneity of central type benzodiazepine receptors in the brain of living baboons.

    abstract：:The feasibility of visualizing the heterogeneity of benzodiazepine (BDZ) receptors in the brain of living baboons was investigated using Positron Emission Tomography. Ethyl 8-fluoro-5,6-dihydro-5-methyl 6-oxo-4H-imidazo (1,5-a) (1, 4) benzodiazepine-3-carboxylate (RO 15 1788) labelled by carbon 11 (11C-RO 15 1788) was...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90363-7

    authors： Mazière M,Hantraye P,Kaijima M,Dodd R,Guibert B,Prenant C,Sastre J,Crouzel M,Comar D,Naquet R

    更新日期：1985-04-29 00:00:00

  • HOTAIRM1 suppresses cell proliferation and invasion in ovarian cancer through facilitating ARHGAP24 expression by sponging miR-106a-5p.

    abstract：AIMS:Ovarian cancer (OC) is the most lethal gynecologic malignant tumors all over the world. HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) has been reported as an important regulator in multiple tumors. However, the functions of HOTAIRM1 in OC and its possible molecular mechanisms remain unclear. MAIN METHODS:qRT-...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117296

    authors： Chao H,Zhang M,Hou H,Zhang Z,Li N

    更新日期：2020-02-15 00:00:00