Chronic treatment with antidepressants, verapamil, or lithium inhibits the serotonin-induced intracellular calcium response in individual C6 rat glioma cells.

abstract：:The behavioral response induced by the intravesical instillation of capsaicin has been investigated in catheter-implanted, freely moving, conscious male and female rats. Intravesical instillation of capsaicin (25 nmol/rat in 0.5 ml) evoked an intense licking directed toward the lower abdominal and perineal skin which ...

journal_title：Life sciences

authors： Lecci A,Giuliani S,Lazzeri M,Benaim G,Turini D,Maggi CA

更新日期：1994-01-01 00:00:00

abstract：:Met-enkephalin, administered microiontophoretically, produced a greater increase in firing in cells in area CA 3-4 in the hippocampus of both young and aged Fisher 344 rats than it did in the CA 1 area. Furthermore, the effect of met-enkephalin on neuronal firing rates was not as great in old rats as it was in young r...

journal_title：Life sciences

authors： Haigler HJ,Cahill LF,Crager MR,Charles E

更新日期：1987-01-12 00:00:00

abstract：:Reabsorption of 125I labeled unmodified and glycated albumin by the proximal tubule was studied using micropuncture technique in wistar rats of different ages. The data show a significant reabsorption of unmodified albumin while the glycated albumin was virtually excluded from reabsorption process. Among different exp...

journal_title：Life sciences

authors： Kowluru A,Kowluru RA,Solomon S,Martinez L

更新日期：1992-01-01 00:00:00

abstract：:We examined whether H(+)-ATPase is involved in the control of cellular action of arginine vasopressin (AVP) to produce adenosine 3', 5'-monophosphate (cAMP) and mobilize cellular free calcium ([Ca2+]i) in rat renal papillary collecting tubule cells in culture. N-Ethylmaleimide (NEM), an inhibitor of H(+)-ATPase, reduc...

journal_title：Life sciences

authors： Ishikawa S,Sakuma N,Okada K,Saito T

更新日期：1993-01-01 00:00:00

abstract：:Three cholecystokinin type B (CCKB) receptor antagonists were labelled with 11C and evaluated ex vivo in rat biodistribution studies. The CCKB antagonists were YF 476 and two other compounds of the basic 3-ureido-1,4-benzodiazepine class. Following tail-vein administration of [11C]-YF 476 exceedingly low levels of rad...

journal_title：Life sciences

authors： Wilson AA,Jin L,Garcia A,DaSilva JN,Houle S

更新日期：2001-02-02 00:00:00

abstract：:The effects of aging on contractile response to angiotensin II and tachyphylaxis to it were investigated using aortic strips from rats aged 1.5, 4 and 22 months. Whether the endothelium was present or not, the contractile response to angiotensin II was greater and tachyphylaxis to it was less in 1.5-month-old rats tha...

journal_title：Life sciences

authors： Wakabayashi I,Sakamoto K,Hatake K,Yoshimoto S,Kurahashi M

更新日期：1990-01-01 00:00:00

abstract：AIM:Beta asarone is the major constituent of oil obtained from Acorus calamus, the Indian traditional medicine plant. Several studies have shown that beta asarone causes liver and cardiac damages but the reproductive toxicity is not well understood. The present study was initiated to investigate whether beta asarone ha...

journal_title：Life sciences

authors： Benny B,George Priya Doss C,Thirumal Kumar D,Asha Devi S

更新日期：2017-03-15 00:00:00

abstract：:Chronopharmacokinetics deals with the study of the temporal changes in absorption, distribution, metabolism and elimination and thus takes into account the influence of time of administration on these different steps. In the last decade, numerous studies have been devoted to chronokinetics: recent advances will be rev...

journal_title：Life sciences

authors： Bruguerolle B,Lemmer B

更新日期：1993-01-01 00:00:00

abstract：:The biosynthesis of phospholipids during differentiation of normal and dystrophic muscle cells was studied using [32Pi] added to primary culture media. Labeled phosphatides were separated by two-dimensional thin-layer chromatography, exposing the plates to HCl vapors between solvents to cleave the alk-1-enyl bonds. Ph...

journal_title：Life sciences

authors： Leskawa KC,Erwin RE,Hogan EL

更新日期：1986-01-13 00:00:00

abstract：:The binding of different gangliosides to rat T-helper lymphocytes was characterized under conditions that decrease CD4 expression on different mammalian T-helper lymphocytes. Saturation binding by monosialylated [3H]-GM1 to rat T-lymphocytes was time- and temperature-dependent, had a dissociation constant (KD) of 2.2 ...

journal_title：Life sciences

authors： Morrison WJ,Offner H,Vandenbark AA

更新日期：1989-01-01 00:00:00

abstract：:Premazepam (PRZ) in vitro competitively displaced 3H-diazepam (DIA), 3H-flunitrazepam (FLU) and 3H-RO 15-1788 from their binding sites on rat brain synaptosomes, with a potency intermediate to other benzodiazepines (BDZs), and Hill coefficients near 1 in different brain regions. Incubation at 37 degrees C reduced prem...

journal_title：Life sciences

authors： Barone D,Colombo G,Glasser A,Luzzani F,Mennini T

更新日期：1984-07-23 00:00:00

abstract：:Defects in the mitochondrial genome have been associated with Parkinson's and Alzheimer's disease, and apoptosis can be triggered by the presence of energetically compromised mitochondria. Thus, in this study we have examined whether the divalent cations Cu2+ and Mn2+ could influence mitochondrial function in vitro. M...

journal_title：Life sciences

authors： Heron P,Cousins K,Boyd C,Daya S

更新日期：2001-02-23 00:00:00

abstract：BACKGROUND:The prevalence and mortality of the outbreak of the COVID-19 pandemic show marked geographic variation. The presence of several subtypes of the coronavirus and the genetic differences in the populations could condition that variation. Thus, the objective of this study was to propose variants in genes that en...

journal_title：Life sciences

authors： Vargas-Alarcón G,Posadas-Sánchez R,Ramírez-Bello J

更新日期：2020-11-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) modulates various events through several different pathways. Many tumor cells are resistant to this cytokine. Pretreatment of these cells with actinomycin D enhances TNF-alpha-induced apoptosis. In the present study, we investigated the mechanism of this enhancement and whether ...

journal_title：Life sciences

authors： Nishida S,Yoshioka S,Kinoshita-Kimoto S,Kotani M,Tsubaki M,Fujii Y,Tomura TT,Irimajiri K

更新日期：2003-12-26 00:00:00

abstract：:In fish liver catecholamines bind to beta-adrenoceptors (AR) and increase glucose release via cAMP augmentation. Alpha1-AR have recently been shown to mediate IP3 and Ca2+ elevation in catfish and eel hepatocytes, although their coupling to a physiological response has remained doubtful. We have perifused isolated cat...

journal_title：Life sciences

authors： Fabbri E,Buzzi M,Biondi C,Capuzzo A

更新日期：1999-01-01 00:00:00

abstract：AIMS:Elevated levels of epidermal growth factor (EGF) receptor are observed on several human tumors, e.g. cervical carcinoma and mamma carcinomas. The natural ligand EGF is an alternative to established antibodies and tyrosine kinase inhibitors for targeting EGF receptor-overexpressing tumor cells for therapy. Conjugat...

journal_title：Life sciences

authors： Bachran C,Schneider S,Riese SB,Bachran D,Urban R,Schellmann N,Zahn C,Sutherland M,Fuchs H

更新日期：2011-01-31 00:00:00

abstract：:The analgesic effects of bestatin and thiorphan, two enzymatic inhibitors protecting endogenous enkephalins from their degradation, and those of DAGO and deltakephalin, respectively mu and delta opioid peptides, are assessed on the electrical stimulation test of the mouse tail. The relative analgesic potency of DAGO a...

journal_title：Life sciences

authors： Chaillet P,Coulaud A,Fournié-Zaluski MC,Gacel G,Roques BP,Costentin J

更新日期：1983-01-01 00:00:00

abstract：:Alzheimer's disease (AD) as a dementia and neurodegenerative disease, is mostly prevalent among people more than 65 years. AD is mostly manifested in the form of degraded mental function, such as losing memory and impaired cognitive function. Due to inefficiency of traditional pharmacological therapeutic approaches wi...

journal_title：Life sciences

authors： Chakari-Khiavi F,Dolati S,Chakari-Khiavi A,Abbaszadeh H,Aghebati-Maleki L,Pourlak T,Mehdizadeh A,Yousefi M

更新日期：2019-08-15 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1) is a 76-amino-acid chemokine thought to be the major chemotactic factor for monocytes. MCP-1 is found in macrophage-rich areas of atherosclerotic lesions. Recent report indicates that MCP-1 is induced by glucose-stimulation, raising the important link between diabetes mellitu...

journal_title：Life sciences

authors： Murao K,Yu X,Cao WM,Imachi H,Chen K,Muraoka T,Kitanaka N,Li J,Ahmed RA,Matsumoto K,Nishiuchi T,Tokuda M,Ishida T

更新日期：2007-07-26 00:00:00

abstract：:The extract of Crataegus, a mixture of flavonoids and procyanidins extracted from hawthorn, Crataegus oxyacantha, L. and C. monogyna Jacq., relaxed vascular tone or increased production of cyclic GMP in the rat aorta, but flavonoid components of Crataegus extract, hyperoside, rutin and vitexin, did not affect the vasc...

journal_title：Life sciences

authors： Kim SH,Kang KW,Kim KW,Kim ND

更新日期：2000-01-01 00:00:00

abstract：AIMS:To investigate the therapeutic effects of human amniotic mesenchymal stem cells (hAMSCs) on paraquat (PQ)-induced pulmonary fibrosis in rats and investigate the inflammatory mechanisms. MAIN METHODS:hAMSCs were identified by morphological, flow cytometry and immunocytochemistry. A pulmonary fibrosis model was ind...

journal_title：Life sciences

authors： He F,Wang Y,Li Y,Yu L

更新日期：2020-02-15 00:00:00

abstract：:Insulin resistance (IR) impairs endothelium-mediated vasodilation in cerebral arteries as well as K+ channel function in vascular smooth muscle. Peripheral arteries also show an impaired endothelium-dependent vasodilation in IR and concomitantly show an enhanced contractile response to endothelin-1 (ET-1). However, th...

journal_title：Life sciences

authors： Simandle SA,Erdös B,Snipes JA,Miller AW,Busija DW

更新日期：2005-09-16 00:00:00

abstract：:The effects of porcine uterine fluid filtrate (PUF) on lymphocyte activity were examined. PUF was added to porcine lymphocyte cultures in the presence or absence of phytohemagglutinin (PHA), concanavalin A (Con A), or pokeweed mitogen (PWM). Lymphocyte response was determined by 3H-thymidine incorporation. Results ind...

journal_title：Life sciences

authors： Li WI,Yang WC

更新日期：1993-01-01 00:00:00

abstract：:Cordyceps sinensis (C. sinensis) is one of the well known fungi used in traditional Chinese medicine for treatment asthma and bronchial and lung inflammation. In this study, effects of C. sinensis methanolic extracts on bronchoalveolar lavage fluids (BALF) cells proliferation, inflammatory cytokines production, and ge...

journal_title：Life sciences

authors： Kuo YC,Tsai WJ,Wang JY,Chang SC,Lin CY,Shiao MS

更新日期：2001-01-19 00:00:00

abstract：:Activation of polyamine metabolism may be important to initiation of pancreatic cell growth. We are reporting that such activation did occur during pancreatic growth initiation by caerulein, a cholecystokinin analog. Maximal increases in total putrescine (319%), spermidine (63%) and spermine (50%) were observed 12, 96...

journal_title：Life sciences

authors： Morisset J,Benrezzak O

更新日期：1984-12-10 00:00:00

abstract：:Doxorubicin (DOX) induced cardiotoxicity is a life-threatening side effect of chemotherapy and decreased cardiac function can present years after treatment. Despite the investigation of a broad range of pharmacologic interventions, to date the only drug shown to reduce DOX-related cardiotoxicity in preclinical studies...

journal_title：Life sciences

authors： Zhen J,Yu H,Ji H,Cai L,Leng J,Keller BB

更新日期：2019-12-15 00:00:00

abstract：:Repeated, low-intensity electrical stimulation of the heart gradually leads to the development of electrocardiographic abnormalities that culminate in cardiac arrhythmias, mainly A-V block in the isolated heart frog and ventricular and supraventricular tachyarrhythmias in the canine heart in situ. The pattern of devel...

journal_title：Life sciences

authors： García-Márquez F,Moreno JA,Luján M,Rodríguez R

更新日期：1988-01-01 00:00:00

abstract：:Amylin is co-secreted with insulin from the pancreas of patients with non-insulin dependent diabetes mellitus, and its deposition may contribute to the central nervous system (CNS) manifestations of this disease. Amylin, but not its mRNA, is found in brain, suggesting that CNS amylin is derived from the circulation. T...

journal_title：Life sciences

authors： Banks WA,Kastin AJ,Maness LM,Huang W,Jaspan JB

更新日期：1995-01-01 00:00:00

abstract：AIMS:Keratinocytes are the predominant cells in the epidermis, exerting their primary role of physical barrier through sophisticated differentiation process. In addition, keratinocytes contribute to the activation of innate immunity, providing the surveillant role against external pathogens. It has been known that chro...

journal_title：Life sciences

authors： Zhou MW,Jiang RH,Kim KD,Lee JH,Kim CD,Yin WT,Lee JH

更新日期：2016-06-15 00:00:00

abstract：:When s-triazolo[3,4-a]phthalazine (Tri-P) was orally administered in rats, a more lipophilic metabolite M-1 than the parent compound was isolated from the urine. The metabolite M-1 was identified as 7-methylthio Tri-P by means of high resolution MS and two-dimensional NMR spectrometry. Furthermore, the 7-methylthio co...

journal_title：Life sciences

authors： Imamura Y,Noda A,Imamura T,Ono Y,Okawara T,Noda H

更新日期：2003-11-21 00:00:00