A novel methylthio metabolite of s-triazolo[3,4-a]phthalazine, a lead compound for the development of antianxiety drugs, in rats.

abstract：:We examined a hypothesis that alpha-Melanocyte Stimulating Hormone (MSH) can antagonizes the anorexia induced by intracerebroventricular injection of corticotropin releasing factor (CRF). Food intake of the rats deprived of food for 18 h was significantly inhibited by 4 h after intracerebroventricular injection of CRF...

journal_title：Life sciences

authors： Oohara M,Negishi M,Shimizu H,Sato N,Mori M

更新日期：1993-01-01 00:00:00

abstract：:We have examined the role of membrane hyperpolarization in mediating vascular hyporeactivity induced by bacterial lipopolysaccharide (LPS) in endothelial-denuded strips of rat thoracic aorta ex vivo. The injection of rats with LPS caused a significant fall of blood pressure and a severe vascular hyporeactivity to nore...

journal_title：Life sciences

authors： Chen SJ,Wu CC,Yang SN,Lin CI,Yen MH

更新日期：2000-12-29 00:00:00

abstract：AIMS:To assess the relationship between endothelial dysfunction, endothelin 1 (ET-1) plasma levels and subclinical inflammation in primary open angle glaucoma (POAG) patients. MAIN METHODS:We enrolled 40 POAG patients with progressive visual field damage, although well controlled intraocular pressure (IOP) and compare...

journal_title：Life sciences

authors： Cellini M,Strobbe E,Gizzi C,Balducci N,Toschi PG,Campos EC

更新日期：2012-10-15 00:00:00

abstract：:There is a growing literature indicating that opioid abuse by human addicts and opioid administration to animals have profound effects on the immune system. In the present study, implantation of morphine pellets in mice was associated with reduced phenotypic expression of the cell surface antigens specific to T-lympho...

journal_title：Life sciences

authors： Kimes AS,Smith WJ,Winchell CJ,London ED

更新日期：1992-01-01 00:00:00

abstract：:The effect of continuous treatment with the selective 5-HT1A agonist gepirone upon 5-HT2-mediated behavior and cortical 5-HT2 receptor binding sites was examined in naive rats or rats receiving noradrenergic (DSP4) or serotonergic (5,7-DHT) lesions. Continuous administration of gepirone in non-lesioned rats for 3, 7, ...

journal_title：Life sciences

authors： Yocca FD,Eison AS,Hyslop DK,Ryan E,Taylor DP,Gianutsos G

更新日期：1991-01-01 00:00:00

abstract：:Effects of sub-acute cocaine treatment on 3H-naloxone binding to 6 brain regions were examined in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. Cocaine hydrochloride (3 mg/kg, i.v.) was given by bolus injection daily for five days. Rats were decapitated 24 hr following the final injection and crude mem...

journal_title：Life sciences

authors： Ishizuka Y,Rockhold RW,Hoskins B,Ho IK

更新日期：1988-01-01 00:00:00

abstract：:The objective of this study was to understand the mechanism of action of nitric oxide (NO) in the heart by determining whether nitric oxide (NO) released from sodium nitroprusside (SNP) induces p38 mitogen activated protein kinase (p38 MAPK) phosphorylation and whether this is mediated through a cyclic GMP (cGMP)/prot...

journal_title：Life sciences

authors： Rabkin SW,Klassen SS,Tsang MY

更新日期：2007-08-02 00:00:00

abstract：AIMS:it has been suggested that Chromium (Cr), one of the essential minerals, can be beneficial to type 2 diabetic patients because it lowers blood glucose levels by improving various steps in insulin action. A few studies reported that Cr might also have some beneficial effects in people with type 1 diabetes mellitus ...

journal_title：Life sciences

authors： Kwon MJ,Chung HS,Yoon CS,Ko JH,Jun HJ,Kim TK,Lee SH,Ko KS,Rhee BD,Kim MK,Park JH

更新日期：2010-09-25 00:00:00

abstract：:The analgesic effects of low current transcranial electrostimulation are both naloxone and pCPA-reversible, suggesting that they may be mediated in part by endogenous opioid and serotonergic activity. The present experiments indicate that pretreatment with the serotonin precursor L-tryptophan results in an increased a...

journal_title：Life sciences

authors： Malin DH,Lake JR,Hamilton RF,Skolnick MH

更新日期：1990-01-01 00:00:00

abstract：:The purpose of this study was to investigate the involvement of calcium in K+ currents and its effects on amino acid accumulation and on the membrane potential regulated by tri-iodo-L-thyronine (T3) in Sertoli cells. Immature rat testes were pre-incubated for 30 min in Krebs-Ringer bicarbonate buffer and incubated for...

journal_title：Life sciences

authors： Volpato KC,Menegaz D,Leite LD,Barreto KP,de Vilhena Garcia E,Silva FR

更新日期：2004-01-23 00:00:00

abstract：:Recent studies have shown that acyl-CoA:cholesterol acyltransferase (ACAT) plays an important role in the initiation of diabetes-associated hypercholesterolemia. To confirm this hypothesis, effects of a potent ACAT inhibitor, FR145237, on diet-induced hypercholesterolemia were examined in streptozotocin (STZ)-induced ...

journal_title：Life sciences

authors： Sakuma Y,Hagihara H,Nagayoshi A,Ohne K,Mutoh S,Ito Y,Nakahara K,Notsu Y,Okuhara M

更新日期：1997-01-01 00:00:00

abstract：:Involvement of a central histaminergic mechanism in the stimulating effect of beta-endorphin (beta-End) on the pituitary-adrenocortical activity, measured indirectly through corticosterone secretion, was investigated in conscious rats. The rise in serum corticosterone levels, induced by beta-End injected intraventricu...

journal_title：Life sciences

authors： Turoń M,Tytoń J,Bugajski J

更新日期：1991-01-01 00:00:00

abstract：:Clinical data indicate that hydroalcoholic extracts of Hypericum perforatum might be as valuable as conventional antidepressants in mild-to-moderate depression, with fewer side effects. One clinical trial using two extracts with different hyperforin contents indicated it as the main active principle responsible for th...

journal_title：Life sciences

authors： Mennini T,Gobbi M

更新日期：2004-07-16 00:00:00

abstract：AIMS:Lithium is a common mood stabilizer to treat bipolar disorder. It has a narrow window of therapeutic action and its mechanism of action and possible side effects are still not fully understood. Lithium is a potent inhibitor of glycogen synthase kinase 3β (GSK-3β). Previous studies indicated that lithium can induce...

journal_title：Life sciences

authors： Tsui MM,Tai WC,Wong WY,Hsiao WL

更新日期：2012-09-24 00:00:00

abstract：:Increasing understanding in tumor pathology reveals that tumor microenvironment (TME), which supports tumor progression and poses barriers for available therapies, takes a great responsibility in inefficient treatment and poor prognosis. In recent years, the versatile nanotechnology employed in TME regulation has made...

journal_title：Life sciences

authors： Li M,Zhang F,Su Y,Zhou J,Wang W

更新日期：2018-05-15 00:00:00

abstract：:We describe here a nonpeptide neuropeptide Y Y1 receptor antagonist, 2,4-dioxo-1,5-bis(2-oxo-2-orthotolyl-ethyl)-3-[3-[3-([3-[3-(3-p iperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propyl]-car bamoyloxymethyl)-phenyl]-ureido]-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diaz epine (Compound 1), which was previously synthesized as...

journal_title：Life sciences

authors： Shigeri Y,Ishikawa M,Ishihara Y,Fujimoto M

更新日期：1998-01-01 00:00:00

abstract：:Guinea pig ileum longitudinal muscle/myenteric plexus preparations contain functional mu- and kappa-opioid receptors. A preparation with blocked kappa receptors was obtained by pretreating guinea pigs with 0.1-10.0 mg/kg intraperitoneal doses of a new kappa-selective affinity label, DIPPA (2-(3,4-dichlorophenyl)-N-met...

journal_title：Life sciences

authors： Schwartz RW,Chang AC,Portoghese PS,Berzetei-Gurske IP

更新日期：1997-01-01 00:00:00

abstract：AIMS:Fudosteine is a cysteine derivative that is used as an expectorant in chronic bronchial inflammatory disorders. It has been shown to decrease the number of goblet cells in an animal model. This study examined the effects of fudosteine on airway inflammation and remodeling in a murine model of chronic asthma. MAIN...

journal_title：Life sciences

authors： Ueno-Iio T,Shibakura M,Iio K,Tanimoto Y,Kanehiro A,Tanimoto M,Kataoka M

更新日期：2013-05-30 00:00:00

abstract：:Based on our earlier animal study, we became interested to investigate if thromboxane A2 (TXA2) is involved in angiotensin converting enzyme (ACE) induced cough in man. To 11 patients with hypertension, who had developed cough induced by ACE inhibitors, a TXA2 synthetase inhibitor, ozagrel was given for 1 to 2 months ...

journal_title：Life sciences

authors： Umemura K,Nakashima M,Saruta T

更新日期：1997-01-01 00:00:00

abstract：AIMS:Honokiol is a natural product extracted from herbal plants such as the Magnolia species which have been shown to exhibit anti-tumor and anti-metastatic properties. However, the effects of honokiol on thyroid cancers are largely unknown. MATERIALS AND METHODS:To determine whether honokiol might be useful for the t...

journal_title：Life sciences

authors： Chou HC,Lu CH,Su YC,Lin LH,Yu HI,Chuang HH,Tsai YT,Liao EC,Wei YS,Yang YT,Chien YA,Yu XR,Lee YR,Chan HL

更新日期：2018-08-15 00:00:00

abstract：:When injected into the substantia nigra reticulata of naive rats, dynorphin-(1-17) caused a dose dependent contralateral rotation which was inhibited by naloxone in a dose dependent manner. Met-enkephalin injected in the same coordinates as the ones used with dynorphin also induced rotation but of lower intensity, whi...

journal_title：Life sciences

authors： Herrera-Marschitz M,Hökfelt T,Ungerstedt U,Terenius L

更新日期：1983-01-01 00:00:00

abstract：:The ability of metformin (MF) to acutely relax phenylephrine (PE)-induced contraction in the isolated rat tail artery is reported to be accompanied by repolarization of the arterial smooth muscle cell (SMC) membranes. These membranes contain potassium (K) channels which if opened could mediate such repolarization and ...

journal_title：Life sciences

authors： Peuler JD,Lee JM,Smith JM

更新日期：1999-10-29 00:00:00

abstract：:The O2 affinity of "stripped" (cofactor-free) hemoglobin (Hb) of the elasmobranch, Squalus acanthias is decreased by ATP, the main erythrocytic phosphate cofactor but increased by urea at physiological concentration. When both compounds are present, as in life, urea decreases the ATP sensitivity, indicating that previ...

journal_title：Life sciences

authors： Weber RE,Wells RM,Tougaard S

更新日期：1983-05-02 00:00:00

abstract：:In an attempt to investigate the role of nucleoside transporter function in the hypertensive state, we have compared the binding of [3H]nitrobenzylthioinosine ([3H]NBMPR), a nucleoside transporter probe, in membranes prepared from platelet, renal, pulmonary, cardiac and brain tissues of spontaneously hypertensive rats...

journal_title：Life sciences

authors： Williams EF,Udofia UP,Brooks GR,Hawk NN

更新日期：1990-01-01 00:00:00

abstract：:PNA+Tempol, albumin containing conjugated (polynitroxyl albumin; PNA) and free (4-hydroxyl-2,2,6,6-tetramethyl-piperidinyl-1-oxyl; Tempol) nitroxide may protect against injury caused by reactive oxygen species. Therefore, the actions of PNA+Tempol on liver injury and inflammation induced by hepatic ischemia and reperf...

journal_title：Life sciences

authors： Blonder JM,McCalden TA,Hsia CJ,Billings RE

更新日期：2000-11-17 00:00:00

abstract：AIM:Acute lung injury (ALI) is characterized by alveolar macrophage overactivation and uncontrolled pulmonary inflammation. Mitochondrial damage-associated molecular patterns (MTDs), one type of damage-associated molecular patterns (DAMPs) released from ruptured mitochondrial, can induce inflammation which participates...

journal_title：Life sciences

authors： Peng W,Peng F,Lou Y,Li Y,Zhao N,Shao Q,Chen J,Qian K,Zeng Z,Zhan Y,Jiang R,Liu F

更新日期：2021-01-15 00:00:00

abstract：:Asthma is a chronic inflammatory and allergic disease that is mainly characterized by reversible airway obstruction and bronchial hyperresponsiveness. The incidence of asthma is increasing with more than 350 million people worldwide are affected. Up to now, there is no therapeutic option for asthma and most of the pre...

journal_title：Life sciences

authors： Al-Azzam N,Elsalem L

更新日期：2020-11-01 00:00:00

abstract：AIMS:The effects of chronic administration of Ferutinin (phytoestrogen found in the plants of genus Ferula), compared with those elicited by estradiol benzoate, were evaluated, following ovariectomy, on the uterus of ovariectomized rats as regard weight, size, structure and histomorphometry. MAIN METHODS:The experimen...

journal_title：Life sciences

authors： Ferretti M,Bertoni L,Cavani F,Benincasa M,Sena P,Carnevale G,Zavatti M,Viesti VD,Zanoli P,Palumbo C

更新日期：2012-01-16 00:00:00

abstract：AIM:Diabetic nephropathy is the leading cause of end stage renal disease in developed countries throughout the world. The imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system is the main problem that is responsible for the progression of diabetic kidney disease. In this s...

journal_title：Life sciences

authors： Kuo CW,Shen CJ,Tung YT,Chen HL,Chen YH,Chang WH,Cheng KC,Yang SH,Chen CM

更新日期：2015-08-15 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is the most prevalent neuromuscular disease worldwide. It is a lethal and progressive neurodegenerative disease, principally affecting motor neurons; patient clinical characteristics are muscle weakness, dysphagia and respiratory failure. The mean age is related to family history (4...

journal_title：Life sciences

authors： Recabarren-Leiva D,Alarcón M

更新日期：2018-01-15 00:00:00