Protein glycation: effects upon protein recognition by the proximal tubule.

abstract：:The effects of morphine-3-glucuronide (M3G) and morphine on the K+-evoked release of [14C]-gamma-aminobutyric acid (GABA) and [3 H]-glutamic acid were investigated in rat brain synaptosomes using superfusion techniques. K+-evoked release of both [14C]-GABA and [3H]-glutamic acid from rat brain synaptosomes was elimina...

journal_title：Life sciences

authors： Bartlett SE,Smith MT

更新日期：1996-01-01 00:00:00

abstract：:Incubation of unfixed, frozen sections of rat pancreas with tritiated guanidinoethylmercaptosuccinic acid (GEMSA) resulted in a localization of [3H]-GEMSA autoradiographic grains over the islets of Langerhans, suggesting that a carboxypeptidase H-like enzyme occurs in the islet. ...

journal_title：Life sciences

authors： Powell AM,Wells MR,Timmers KI,Recant L

更新日期：1987-06-29 00:00:00

abstract：:The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is rapidly metabolized to a 1-methyl-4-phenylpyridinium species (MPP+) in the squirrel monkey. After administration of toxic doses of MPTP, the concentration of MPP+ in the substantia nigra appears to increase during the first 72 hours, reaching the hi...

journal_title：Life sciences

authors： Irwin I,Langston JW

更新日期：1985-01-21 00:00:00

abstract：:Silica (SiO2) nanoparticles (NPs) were synthesized by laser ablation method and were characterized by TEM and DLS techniques. Afterwards, their inhibition activity against carbonic anhydrase (CA) isoforms (CA I and CA II) was explored by experimental and theoretical analysis. Also, the protective effect of SiO2 NPs ag...

journal_title：Life sciences

authors： Xu N,Lu W,Meng L,Feng X,Xuan J,Liu F,Feng Z

更新日期：2021-01-12 00:00:00

abstract：:Ozone is a highly efficient disinfectant which may have significant advantages in water treatment compared to chlorine. It has, however, been shown that mutagenic and possibly carcinogenic byproducts may be produced under certain conditions of ozonation. Light chlorination following ozonization may meet the highest st...

journal_title：Life sciences

authors： Carmichael NG,Winder C,Borges SH,Backhouse BL,Lewis PD

更新日期：1982-01-11 00:00:00

abstract：:The present study shows that morphine reduces the pulmonary inflammatory response to intranasal influenza virus infection in rats. Rats were infected with rat-adapted influenza virus (RAIV), which is a unique infectious agent because normal rats develop an acute pulmonary inflammatory response to RAIV and rapidly clea...

journal_title：Life sciences

authors： Coussons-Read ME,Daniels M,Gilmour MI

更新日期：1999-01-01 00:00:00

abstract：:CYP3A4, the predominant cytochrome P450 (CYP) expressed in human liver, contributes to the metabolism of approximately half the drugs in use today. In general, human-derived cell lines fail to express CYPs. It was previously shown that CYP3A4 mRNA and CYP3A immunoreactive protein are induced by 1alpha,25-dyhydroxyvita...

journal_title：Life sciences

authors： Elizondo G,Medina-Díaz IM

更新日期：2003-05-30 00:00:00

abstract：AIMS:The aim of this work was to examine the antitumor effects and mechanisms of M4IDP, a zoledronic acid derivative, on human colorectal cancer (CRC) HCT116 cells. MAIN METHODS:The effects of M4IDP on proliferation, cell cycle and ROS production were determined by CCK-8 and flow cytometry assays. Annexin-V-FITC/PI, H...

journal_title：Life sciences

authors： Peng Y,Qiu L,Xu D,Zhang L,Yu H,Ding Y,Deng L,Lin J

更新日期：2017-09-15 00:00:00

abstract：OBJECTIVE:Metformin, introduced in 1957, is widely used as an anti-diabetic drug and has considerable benefits in cardiovascular disease reportedly, dependent or independent on its glucose-lowering effects. Aim of this study was to investigate the effect of metformin on gap junction and the inducibility of AF. METHODS...

journal_title：Life sciences

authors： Li J,Li B,Bai F,Ma Y,Liu N,Liu Y,Wang Y,Liu Q

更新日期：2020-08-01 00:00:00

abstract：:The COVID-19 pandemic raised by SARS-CoV-2 is a public health emergency. However, lack of antiviral drugs and vaccine against human coronaviruses demands a concerted approach to challenge the SARS-CoV-2 infection. Under limited resource and urgency, combinatorial computational approaches to identify the potential inhi...

journal_title：Life sciences

authors： Bharadwaj S,Lee KE,Dwivedi VD,Kang SG

更新日期：2020-09-15 00:00:00

abstract：:We examined whether H(+)-ATPase is involved in the control of cellular action of arginine vasopressin (AVP) to produce adenosine 3', 5'-monophosphate (cAMP) and mobilize cellular free calcium ([Ca2+]i) in rat renal papillary collecting tubule cells in culture. N-Ethylmaleimide (NEM), an inhibitor of H(+)-ATPase, reduc...

journal_title：Life sciences

authors： Ishikawa S,Sakuma N,Okada K,Saito T

更新日期：1993-01-01 00:00:00

abstract：AIMS:Porcelain-fused-to-metal (PFM) crowns are a standard restoration technique in dentistry, but toxicity of PFM in vivo has not been systematically evaluated. The present study evaluated the effects of various metal alloy shells of PFM crowns on the development of zebrafish embryos and larvae in order to determine th...

journal_title：Life sciences

authors： Zhao L,Si J,Wei Y,Li S,Jiang Y,Zhou R,Liu B,Zhang H

更新日期：2018-06-15 00:00:00

abstract：:Time-course studies revealed the increased susceptibility of the gastric mucosa to noxious injury in portal hypertension correlates with the level of elevated portal venous pressure and hyperglucagonemia. Whether acute elevation of portal venous pressure by exogenous glucagon aggravates such injury is not known. We te...

journal_title：Life sciences

authors： Tsui CP,Sung JJ,Leung FW

更新日期：2003-07-18 00:00:00

abstract：:The concentrations of the trace amines, m-tyramine, p-tyramine, phenylethylamine and tryptamine, were measured in the striatum of the brain and in the kidney of adult rats treated with alpha-monofluoromethyldopa (MFMD), an inhibitor of aromatic amino acid decarboxylase. While MFMD decreased the levels of all four amin...

journal_title：Life sciences

authors： Dyck LE

更新日期：1987-02-09 00:00:00

abstract：:The decrease of m-AChR density observed in neurodegenerative disorders has generated considerable interest in non-invasive mapping of muscarinic acetylcholine receptors (m-AChR) in the central nervous system. The aim of our study was to evaluate the selectivity of 4-bromodexetimide for the M1, M2, M3 and M4 m-AChR sub...

journal_title：Life sciences

authors： Strijckmans V,Coulon C,Kassiou M,Loc'h C,Mazière B

更新日期：1996-01-01 00:00:00

abstract：:Inflammation, inflammatory mediators, cyclooxygenase (COX)-2, and inducible nitric oxide (iNOS) are all influenced by age-related oxidative status. To investigate the effect of dietary fish oil (FO) and calorie restriction (CR) on oxidative stress-related inflammatory status with age, (NZB/NZW) F1 (B/W) mice were fed ...

journal_title：Life sciences

authors： Kim YJ,Kim HJ,No JK,Chung HY,Fernandes G

更新日期：2006-04-18 00:00:00

abstract：:The thyrotropin receptor is proposed to contain both a glycoprotein and a ganglioside component. Monoclonal antibodies have been developed against soluble thyroid TSH receptor preparations and using Graves' lymphocytes. These show that initial recognition of thyrotropin requires the glycoprotein component, but that mo...

journal_title：Life sciences

authors： Kohn LD,Valente WA,Laccetti P,Cohen JL,Aloj SM,Grollman EF

更新日期：1983-01-03 00:00:00

abstract：:Colorectal cancer remains to be the most prevalent malignancy in humans and 1.5 million men and women living in the United States are diagnosed with colorectal cancer, with a predicted 145,600 new cases to be diagnosed in 2019. Curcuminoids and its synthetic analogs are now of interest due to their bioactive attribute...

journal_title：Life sciences

authors： Selvam C,Prabu SL,Jordan BC,Purushothaman Y,Umamaheswari A,Hosseini Zare MS,Thilagavathi R

更新日期：2019-12-15 00:00:00

abstract：:Ipriflavone, 7-isopropoxy-3-phenyl-4H-1-benzopyran-4-one, was administered orally for 12 weeks to male rats with prednisolone-induced osteoporosis. Microdensitometric analysis of a roentgenograph of the femurs revealed that ipriflavone increased the density of the distal metaphysis dose-dependently and tended to incre...

journal_title：Life sciences

authors： Yamazaki I,Shino A,Shimizu Y,Tsukuda R,Shirakawa Y,Kinoshita M

更新日期：1986-03-10 00:00:00

abstract：:The effect of prior incubation with a single concentration of isoproterenol (10(-4) M) for 2 hours at 37 degrees C on isoproterenol-stimulated cyclic AMP accumulation in intact lymphocytes from young, old and subjects with Alzheimer's disease was studied. In lymphocytes from all three subjects groups prior incubation ...

journal_title：Life sciences

authors： Oppenheim G,Mintzer J,Halperin Y,Eliakim R,Stessman J,Ebstein RP

更新日期：1984-10-22 00:00:00

abstract：AIMS:Multiple sclerosis (MS) whose pathogenesis is still unclear is a chronic progressive disease in the central nervous system. Gut microbiota can directly or indirectly affect the immune system through the brain gut axis to engage in the occurrence and development of the disease. MATERIALS AND METHODS:C57BL/6 mice w...

journal_title：Life sciences

authors： Xu L,Zhang C,He D,Jiang N,Bai Y,Xin Y

更新日期：2020-07-15 00:00:00

abstract：:[3H]5-HT binding sites were analyzed in membranes prepared from the rabbit caudate nucleus (CN). [3H]5-HT labeled both 5-HT1A and 5-HT1C recognition sites, defined by nanomolar affinity for 8-OH-DPAT and mesulergine respectively; however, these represented only a fraction of total specific [3H]5-HT binding. Saturation...

journal_title：Life sciences

authors： Xiong WC,Nelson DL

更新日期：1989-01-01 00:00:00

abstract：AIMS:To investigate how Placental Mesenchymal Stem Cells (P-MSCs) would adapt themselves and survive under hypoxic conditions which are prevalent in most injury sites. MAIN METHODS:P-MSCs were isolated from term placenta and characterised under normoxia and hypoxia (2-2.5% O2). Cells were examined for morphology and s...

journal_title：Life sciences

authors： Mathew SA,Chandravanshi B,Bhonde R

更新日期：2017-08-01 00:00:00

abstract：AIMS:Naphtho[1,2-b]furan-4,5-dione (NFD), prepared from 2-hydroxy-1,4-naphthoquinone and chloroacetaldehyde in an efficient one-pot reaction, exhibits an anti-carcinogenic effect. This study was performed to elucidate whether EGFR and PI3K signaling pathways are involved in NFD-induced apoptosis of human lung adenocarc...

journal_title：Life sciences

authors： Su JC,Lin KL,Chien CM,Tseng CH,Chen YL,Chang LS,Lin SR

更新日期：2010-01-30 00:00:00

abstract：:Chromogranin A (CgA) is an acidic protein co-released with catecholamines during exocytosis from sympathetic nerve terminals and chromaffin cells. Previous work has demonstrated that large scale perturbations in sympathetic nervous system (SNS) functioning result in corresponding changes in CgA levels in plasma. Littl...

journal_title：Life sciences

authors： Dimsdale JE,O'Connor DT,Ziegler M,Mills P

更新日期：1992-01-01 00:00:00

abstract：AIMS:Acetylcholine is synthesized in more or less all mammalian cells. However, little is known about the subcellular location of acetylcholine synthesis. Therefore, in the present experiments the subcellular location of the synthesizing enzyme choline acetyltransferase (ChAT) was investigated by anti-ChAT immunogold e...

journal_title：Life sciences

authors： Wessler I,Michel-Schmidt R,Brochhausen C,Kirkpatrick CJ

更新日期：2012-11-27 00:00:00

abstract：:The sodium-ion coupled transporters for 5-hydroxytryptamine (5HT), noradrenaline and dopamine function to reduce extracellular levels of biogenic amines. Over the past fifteen years selective inhibitors of these transport systems have been developed including fluoxetine, citalopram, paroxetine, litoxetine (for 5HT), n...

journal_title：Life sciences

authors： Graham D,Langer SZ

更新日期：1992-01-01 00:00:00

abstract：:Voltage-dependent Ca2+ channels of fura-2-loaded ganglionic cells from the myenteric plexus of newborn rats were pharmacologically characterised. In contrast to completely dissociated myenteric cells, intact ganglia showed a stronger loading with the Ca2+-sensitive dye and a reproducible stimulation of the fura-2 sign...

journal_title：Life sciences

authors： Schäufele N,Diener M

更新日期：2005-09-30 00:00:00

abstract：:The role of extracellular acidosis in inflammatory airway diseases is not well known. One consequence of tissue acidification is the stimulation of sensory nerves via the polymodal H(+)-gated transmembrane channels ASICs and TRPV1 receptor. The present study investigated the effect of acidosis on airway basal tone and...

journal_title：Life sciences

authors： Faisy C,Planquette B,Naline E,Risse PA,Frossard N,Fagon JY,Advenier C,Devillier P

更新日期：2007-09-08 00:00:00

abstract：:The roles of capsaicin-sensitive sensory nerves (CPSN), endogenous nitric oxide (NO), sulfhydryls (SHs), prostaglandins (PGs) in the gastroprotection by momordin Ic, an oleanolic acid oligoglycoside isolated from the fruit of Kochia scoparia (L.) SCHRAD., on ethanol-induced gastric mucosal lesions were investigated in...

journal_title：Life sciences

authors： Matsuda H,Li Y,Yoshikawa M

更新日期：1999-01-01 00:00:00