Role of acute elevation of portal venous pressure by exogenous glucagon on gastric mucosal injury in rats with portal hypertension.

abstract：AIMS:Enhancing myogenesis has been identified as a possible target to improve insulin sensitivity and protect against metabolic diseases. Catalpol, an iridoid glycoside, has been shown to exert a hypoglycaemic effect by improvement of insulin sensitivity; however, the underlying mechanism remains unknown. In this study...

journal_title：Life sciences

authors： Xu D,Wang L,Jiang Z,Zhao G,Hassan HM,Sun L,Fan S,Zhou Z,Zhang L,Wang T

更新日期：2018-09-15 00:00:00

abstract：:Synaptic mechanisms were studied ex vivo in the aged rat hippocampus, using a slice preparation and intracellular electrophysiological recordings of the CA1 pyramidal neurons. A dramatic depression of the slow cholinergic excitatory postsynaptic potential (EPSP) and of the slow, GABAB-mediated inhibitory postsynaptic ...

journal_title：Life sciences

authors： Krzywkowski P,Potier B,Billard JM,Dutar P,Lamour Y

更新日期：1996-01-01 00:00:00

abstract：AIMS:We investigated the implication of PKA and Epac proteins in the endothelium-independent vasorelaxant effects of cyclic AMP (cAMP). MAIN METHODS:Cytosolic Ca(2+) concentration ([Ca(2+)]c) was measured by fura-2 imaging in rat aortic smooth muscle cells (RASMC). Contraction-relaxation experiments were performed in ...

journal_title：Life sciences

authors： Cuíñas A,García-Morales V,Viña D,Gil-Longo J,Campos-Toimil M

更新日期：2016-06-15 00:00:00

abstract：:This study was designed to document possible changes in bupivacaine kinetics in mice after a single 1 mg/kg injection of flumazenil. After a single 20 mg/kg i.p. dose of bupivacaine, C max, Vd, Cl and AUC were not significantly modified by flumazenil; even if T max was shown to be significantly shorter when flumazenil...

journal_title：Life sciences

authors： Bruguerolle B,Lorec AM

更新日期：1993-01-01 00:00:00

abstract：:Acute ingestion of ethanol impairs memory, an effect which might be related to ethanol-induced inhibition of vasopressin release. This was studied using tests of memory and cognitive function in 26 normal subjects before and after ethanol ingestion. Equal numbers of subjects received randomly, by double-blind intranas...

journal_title：Life sciences

authors： Eisenhofer G,Lambie DG,Robinson BJ

更新日期：1985-12-30 00:00:00

abstract：AIMS:Cortisol is a glucocorticoid in mammals, but has both gluco- and mineralocorticoid activities in teleost fish. Our previous in vivo studies on osmoregulatory esophagi of euryhaline fish showed that epithelial apoptosis for the simple epithelium in seawater and cell proliferation for the stratified epithelium in fr...

journal_title：Life sciences

authors： Takagi C,Takahashi H,Kudose H,Kato K,Sakamoto T

更新日期：2011-01-31 00:00:00

abstract：:A highly purified rat urinary bladder smooth muscle cell culture was obtained by a modified enzymic isolation method, and the presence of functional muscarinic as well as beta-adrenergic receptors were subsequently determined. At 7-10 days of culture, cells became elongated and spindle-shaped showing a typical "hills ...

journal_title：Life sciences

authors： Ma FH,Higashira-Hoshi H,Itoh Y

更新日期：2002-01-25 00:00:00

abstract：:Since reduced levels of brain serotonin are known to cause behavioural abnormalities, to which diabetics are also prone, we investigated the effect, in rats, of chronic diabetes on brain serotonin concentration and on the numbers of 5-HT(1A) and 5-HT2 receptors in cerebral cortex and brainstem. Our data show that stre...

journal_title：Life sciences

authors： Sandrini M,Vitale G,Vergoni AV,Ottani A,Bertolini A

更新日期：1997-01-01 00:00:00

abstract：:The content of lactic acid in red blood cells, plasma, and Ehrlich ascites tumor cells were measured by a gas-liquid chromatography using a column with a terephtalic acid support coated with polyethylene glycol-6000. The lactic acid contents were directly determined in aqueous samples, because they were converted to a...

journal_title：Life sciences

authors： Kageyama K,Onoyama Y,Nakajima T,Tumura M,Nishida T,Kogawa H,Tanabe K

更新日期：1992-01-01 00:00:00

abstract：:The induction of aldose reductase (AR) mRNA expression and its activity by glucose were investigated in fetal rat aortic smooth muscle (A10) cells. The increase in the expression of AR mRNA was observed at 6 h, and reached a maximum (2.3 fold) at 12 h after exposure to 80 mM glucose. On the other hand, increase in AR ...

journal_title：Life sciences

authors： Tawata M,Ohtaka M,Hosaka Y,Onaya T

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Dental pulp stem cells (DPSC) are promising tools in regenerative medicine due to their differentiation potential and immunomodulatory properties. However, it is not clearly known whether or not DPSCs maintain their immunosuppressive effects after differentiation. In the present study, we examined t...

journal_title：Life sciences

authors： Hossein-Khannazer N,Hashemi SM,Namaki S,Ghanbarian H,Sattari M,Khojasteh A

更新日期：2019-01-01 00:00:00

abstract：:The effect of clotrimazole on Ca2+ signaling in Madin Darby canine kidney (MDCK) cells was investigated by using fura-2 as a Ca2+ indicator. Clotrimazole (1-30 microM) induced a concentration-dependent [Ca2+]i increase. The [Ca2+]i increase comprised an initial rise and a slow decay. External Ca2+ removal partly inhib...

journal_title：Life sciences

authors： Jan CR,Tseng CJ,Chou KJ,Chiang HT

更新日期：2000-01-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA), a major steroid secreted by the adrenal gland, is known to have antiproliferative effects but the mechanism is unclear. We recently reported that DHEA induces growth inhibition and apoptosis in BV-2 cells and these effects are inversely associated with glucose concentrations in the mediu...

journal_title：Life sciences

authors： Yang NC,Jeng KC,Ho WM,Hu ML

更新日期：2002-03-15 00:00:00

abstract：:Ethanol consumption was correlated with changes in acyl group profiles of phosphatidylcholine and triacylglycerols in serum of Sinclair(S-1) miniature boars. Serum triacylglycerols in the control pigs were high in linoleate (18:2) (48%) and low in stearate (18:0 (3%). Upon feeding with 10% (w/v) ethanol ad lib for two...

journal_title：Life sciences

authors： Foudin L,Tumbleson ME,Sun AY,Geisler RW,Sun GY

更新日期：1984-02-27 00:00:00

abstract：:A monoclonal antibody (C351) against alpha human atrial natriuretic polypeptide (alpha hANP) recognizing human form ring structure was established and applied to a radioimmunoassay of plasma alpha hANP. The minimum detectable amount in terms of 10% radioligand displacement relative to zero dose were 0.28 fmol/tube, co...

journal_title：Life sciences

authors： Naomi S,Umeda T,Iwaoka T,Miura F,Ohno M,Sasaki M,Oishi S,Sato T,Takatsu K

更新日期：1988-01-01 00:00:00

abstract：:Nociceptin/orphanin FQ (=N/OFQ), the endogenous ligand of ORL1 receptor (=NOP), has been reported to induce, in rodents, after intracerebroventricular (i.c.v.) administration, anti-stress and anxiolytic effects. We have observed that the handling of mice followed by an i.c.v. injection of saline, induced a marked incr...

journal_title：Life sciences

authors： Le Cudennec C,Naudin B,Do Rego JC,Costentin J

更新日期：2002-11-29 00:00:00

abstract：:This study examines the effects of prenatal cocaine administration on the development of vascular sympathetic innervation and contractile responsiveness. Rabbits received cocaine (4 mg/kg, iv, bid) or saline during gestational days 8 to 29. Aortas were obtained on postnatal days 10, 20, 30 and 50. Vascular smooth musc...

journal_title：Life sciences

authors： Johnson MD,Gurdal H,Cai G,Snyder DL,Roberts J

更新日期：1994-01-01 00:00:00

abstract：:6-mercaptopurine (6-MP) has been used clinically for 40 years to maintain remission in patients with acute lymphoblastic leukemia (ALL). However, central nervous system (CNS) relapses frequently occur in patients with ALL who continuously receive anticancer drugs, including 6-MP, during remission maintenance therapy. ...

journal_title：Life sciences

authors： Deguchi Y,Yokoyama Y,Sakamoto T,Hayashi H,Naito T,Yamada S,Kimura R

更新日期：2000-01-01 00:00:00

abstract：AIMS:Diabetes increases oxidant stress and impairs endothelium-dependent relaxation. We investigated whether the antioxidant 3',4'-dihydroxyflavonol (DiOHF) reduces the release of superoxide (O(2)(-)) and preserves endothelial function in aortae from diabetic rats. MAIN METHODS:Type-1 diabetes was induced in Sprague-D...

journal_title：Life sciences

authors： Woodman OL,Malakul W

更新日期：2009-07-03 00:00:00

abstract：AIMS:The aim of the study was to identify key miRNAs related to hepatocellular carcinoma (HCC) and then to explore their potential function and clinical significance. MATERIALS AND METHODS:The miRNA expression profiles of 387 HCC and 62 normal liver tissues were obtained from the Gene Expression Omnibus (GEO) and The ...

journal_title：Life sciences

authors： Wang X,Gao J,Zhou B,Xie J,Zhou G,Chen Y

更新日期：2019-09-01 00:00:00

abstract：:Pregnant mice are more susceptible to flurothyl-induced seizures than are non-pregnant controls. The possibility that the well-known increase in beta-endorphin concentration which accompanies pregnancy was involved in this effect was examined by testing whether naloxone administration could block the increased seizure...

journal_title：Life sciences

authors： Smolen A,Smolen TN,van de Kamp JL

更新日期：1986-05-26 00:00:00

abstract：AIMS:To identify the target of an adipose specific aptamer adipo-8, predict the potential interaction between adipo-8 and its target, and investigate lipid-lowering effect of adipo-8 in vitro and in vivo. MAIN METHODS:Distinct membranous protein of 3T3-L1 adipocyte pulled-down by adipo-8 was mass-spectrometry analyzed...

journal_title：Life sciences

authors： Zhong W,Zhang Y,Tan W,Zhang J,Liu J,Wang G,Liao J,Liu B,Chen K,Yu B,Deng Y,Zou Y,Pu Y,Liu H

更新日期：2020-06-15 00:00:00

abstract：:Since many patients complain about halitosis without there being any clinical evidence of its cause, psychological symptoms have been pointed out as halitosis-inducing factors. The aim of this study was to evaluate the influence of anxiety on the production of volatile sulfur compounds (VSC). Seventeen undergraduate m...

journal_title：Life sciences

authors： Calil CM,Marcondes FK

更新日期：2006-07-10 00:00:00

abstract：AIMS:Our overall objective was to investigate the effect of the adenosine derivative 2',3',5'-tri-O-acetyl-N6-(3-hydroxylaniline) adenosine (WS010117) on AMP-activated protein kinase (AMPK) activation and lipid metabolism and to also assess the underlying mechanisms involved in these processes. MAIN METHODS:HepG2 cell...

journal_title：Life sciences

authors： Guo P,Lian ZQ,Sheng LH,Wu CM,Gao J,Li J,Wang Y,Guo YS,Zhu HB

更新日期：2012-01-02 00:00:00

abstract：:In order to understand the mechanism of increasing body fat in perimenopausal and postmenopausal women, an ovariectomy-induced obesity model was used to study the role of leptin. In this investigation, a long-term study lasted for 13 weeks was conducted to monitoring the change of serum leptin level in rats after the ...

journal_title：Life sciences

authors： Chu SC,Chou YC,Liu JY,Chen CH,Shyu JC,Chou FP

更新日期：1999-01-01 00:00:00

abstract：:Dihydroergosine (50 and 100 mg/kg) enhanced the incidence of bicuculline (3 mg/kg)-induced convulsions in female rats, while 100 mg/kg of dihydroergosine given to female mice made 45% convulsive dose of bicuculline (2.5 mg/kg) to be subconvulsive. The same dose of dihydroergosine enhanced in mice the latency of bicucu...

journal_title：Life sciences

authors： Pericić D,Tvrdeić A

更新日期：1990-01-01 00:00:00

abstract：:Renal compensatory hypertrophy (RCH) occurs in hypothyroid rate, but it is impaired when compared to RCH found in euthyroid controls. It is due to cellular hypertrophy as the DNA content does not change and the Protein/DNA ratio increases in the compensating kidney. RCH is enhanced by thyroxine (T4) with a rise in the...

journal_title：Life sciences

authors： Stéphan F,Réville P,de Laharpe F,Köll-Back MH

更新日期：1982-02-15 00:00:00

abstract：AIMS:Tetramethylpyrazine (TMP), one of the active ingredients isolated from a Chinese herbal prescription, possesses protective effects against oxidative stress caused by high glucose in endothelial cells. In this study, the role of TMP in preventing muscle cells from palmitate-induced oxidative damage was investigated...

journal_title：Life sciences

authors： Gao X,Zhao XL,Zhu YH,Li XM,Xu Q,Lin HD,Wang MW

更新日期：2011-04-25 00:00:00

abstract：AIMS:This experiment investigated the effects of sub-chronic aluminum chloride (AlCl3) exposure on rat ovaries. MAIN METHODS:Eighty female Wistar (5weeks old) rats, weighed 110-120g, were randomly divided into four treatment groups: control group (CG), low-dose group (LG, 64mg/kg BW AlCl3), mid-dose group (MG, 128mg/k...

journal_title：Life sciences

authors： Fu Y,Jia FB,Wang J,Song M,Liu SM,Li YF,Liu SZ,Bu QW

更新日期：2014-03-28 00:00:00

abstract：:We have evaluated the effect of intraperitoneal (I.P.) injection of human recombinant interferon-2alpha (IFN-alpha) on Bleomycin-induced pulmonary injury in hamsters. Pulmonary injury was induced by a single intratracheal (I.T.) instillation of Bleomycin (Bleo). Six groups of male Syrian hamsters were treated as follo...

journal_title：Life sciences

authors： Berkman N,Goldstein RH,Breuer R

更新日期：1997-01-01 00:00:00