Abstract：
:This study was designed to document possible changes in bupivacaine kinetics in mice after a single 1 mg/kg injection of flumazenil. After a single 20 mg/kg i.p. dose of bupivacaine, C max, Vd, Cl and AUC were not significantly modified by flumazenil; even if T max was shown to be significantly shorter when flumazenil was associated, bupivacaine bioavailability did not seem to be modified and thus may not be involved in the explanation of previously reported increasing bupivacaine-induced mortality by flumazenil.
journal_name
Life Scijournal_title
Life sciencesauthors
Bruguerolle B,Lorec AMdoi
10.1016/0024-3205(93)90073-csubject
Has Abstractpub_date
1993-01-01 00:00:00pages
PL165-7issue
17eissn
0024-3205issn
1879-0631pii
0024-3205(93)90073-Cjournal_volume
52pub_type
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