Abstract：
:The binding of different gangliosides to rat T-helper lymphocytes was characterized under conditions that decrease CD4 expression on different mammalian T-helper lymphocytes. Saturation binding by monosialylated [3H]-GM1 to rat T-lymphocytes was time- and temperature-dependent, had a dissociation constant (KD) of 2.2 +/- 1.4 microM and a binding capacity near 2 fmoles/cell. Competitive inhibition of [3H]-GM1 binding demonstrated a structural-activity related to the number of unconstrained sialic acid moieties on GM1-congeneric gangliosides. A comparison between the results of these binding studies and ganglioside-induced decrease of CD4 expression demonstrated that every aspect of [3H]-GM1 binding concurs with ganglioside modulation of CD4 expression. It is concluded that the specific decrease of CD4 expression induced by pretreatment with gangliosides involves the initial process of ganglioside binding to specific sites on CD4+ T-helper lymphocytes.
journal_name
Life Scijournal_title
Life sciencesauthors
Morrison WJ,Offner H,Vandenbark AAdoi
10.1016/0024-3205(89)90123-9subject
Has Abstractpub_date
1989-01-01 00:00:00pages
1219-26issue
14eissn
0024-3205issn
1879-0631pii
0024-3205(89)90123-9journal_volume
45pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：AIM:There is a specific frequency of extremely low-frequency electromagnetic field (ELF-EMF) that promotes neuronal differentiation. Although several mechanisms are known to regulate ELF-EMF-induced neuronal differentiation, a key factor that mediates neurogenic potentials by the ELF-EMF is largely unknown. Also, the p...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.02.022
更新日期：2014-04-25 00:00:00
abstract：:Transcription factor Gata3 is implicated in the formation of autosomal dominant hypoparathyroidism, sensorineural deafness, and renal anomaly (HDR) syndrome. We pursued to identify the potential Gata3 target genes by profiling the gene expression pattern in E9.5 Gata3-/- mouse embryos. Altogether four independent micr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.10.054
更新日期：2005-04-15 00:00:00
abstract：:Trichosanthin (TCS) is a type 1 ribosome-inactivating protein (RIP) effective against HIV-1 and HSV-1 replication. The mechanism of its antiviral activity is not clear. Many believe that it is related to ribosome inactivation. Some RIPs and viral infection affect the phosphorylation of MAPK and Bcl-2 and these protein...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.03.047
更新日期：2006-08-22 00:00:00
abstract：AIMS:We previously reported that cysteinyl leukotriene receptor 2 (CysLT(2)) mediates ischemic astrocyte injury, and leukotriene D(4)-activated CysLT(2) receptor up-regulates the water channel aquaporin 4 (AQP4). Here we investigated the mechanism underlying CysLT(2) receptor-mediated ischemic astrocyte injury induced ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.10.025
更新日期：2011-01-03 00:00:00
abstract：:Insulin binding and 3-0-Methylglucose transport have been studied in erythrocyte- and reticulocyte-enriched fractions of blood cells in order to determine if the increased number of insulin binding sites in reticulocytes is associated with a glucose transport response to insulin. In these experiments rabbit reticulocy...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90588-4
更新日期：1982-07-19 00:00:00
abstract：:The effect of chronic cigarette smoke exposure on the activity of rat trachea and lung ornithine decarboxylase (ODC) and s-adenosyl-methionine decarboxylase (AdoMet-DC) was determined. Male rats were exposed once daily for 10 min to mainstream (MS) or different sidestream (SS) dilutions of fresh Kentucky 2R1 cigarette...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90567-3
更新日期：1985-12-09 00:00:00
abstract：:This experiment was designed to assess the role of the septo-hippocampal cholinergic (ACh) system in the deleterious effects produced by systemic benzodiazepine injection on learning processes in rats. Retention of a step through passive avoidance task was analysed after systemic injection of increasing doses of eithe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00092-2
更新日期：1999-01-01 00:00:00
abstract：:Reoxygenation of the ischemic tissue promotes the generation of various reactive oxygen metabolites (ROM) which are known to have deleterious effects on various cellular functions. This study was designed to determine the possible protective effect of mesna (2-Mercaptoethane Sulfonate) on renal ischemia/reperfusion (I...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.04.029
更新日期：2004-09-24 00:00:00
abstract：:To clarify the mechanism by which Delta9-tetrahydrocannabinol, a major psychoactive component of marijuana, impairs spatial memory in the 8-arm radial maze in rats via the cholinergic system, we used two acetylcholinesterase inhibitors, physostigmine and tetrahydroaminoacridine. Moreover, we examined the effect of Del...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)02274-9
更新日期：2002-12-20 00:00:00
abstract：:Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently defined as the worst pandemic disease. SARS-CoV-2 infects human cells via the binding of its S protein to the receptor angiotensin-converting enzyme (ACE2). The use of ACEIs/ARBs (RAAS inhibitors) ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118142
更新日期：2020-09-15 00:00:00
abstract：AIMS:Steroid hormones and steroid receptors (SRs) play a crucial role in spermatogenesis. Steroid receptor coregulators are the major determinants of SR functioning, and any alteration in their expression is known to be associated with impaired spermatogenesis. Since Bisphenol A (BPA) exposure leads to an impairment of...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.04.005
更新日期：2009-07-03 00:00:00
abstract：AIMS:We investigated whether cAMP-mediated protein kinase A(PKA) and Epac1/Rap1 pathways differentially affect brain tumor cell death using 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone(rolipram), specific phosphodiesterase type IV(PDE IV) inhibitor. MAIN METHODS:A172 and U87MG human glioblastoma cells were used....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.12.010
更新日期：2012-02-27 00:00:00
abstract：:Eleven patients with Raynaud's syndrome accompanied by monospecific IgG ANA, nine patients with Raynaud's syndrome in the absence of ANA, and nine normal volunteers were exposed to an ambient cold challenge during which time venous blood was continuously sampled. ANA negative patients were shown to have significantly ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90930-x
更新日期：1983-02-28 00:00:00
abstract：AIMS:In this study, we investigated the effects of Bax-inhibiting peptide (Bip)-V5, an anti-apoptosis membrane-permeable peptide, on the 6-hydroxydopamine (6-OHDA) induced Parkinson's disease (PD) model rats. MATERIALS AND METHODS:Rats were randomly divided into five groups: Control, 6-OHDA only, Vehicle+6-OHDA, zVAD+...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.11.019
更新日期：2016-01-01 00:00:00
abstract：:The outbreak of COVID-19 in December 2019, has become an urgent and serious public health emergency. At present, there is no effective treatment or vaccine for COVID-19. Therefore, there is a crucial unmet need to develop a safe and effective treatment for COVID-19 patients. Mesenchymal stem cells (MSCs) are widely us...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118493
更新日期：2020-12-01 00:00:00
abstract：:Much evidence has gathered that nitric oxide (NO) signaling, via cGMP-dependent mechanisms, may activate pro-survival pathways in hippocampal neurons and inhibit apoptosis. Past research has revealed that the enhancement of monoaminergic neurotransmission via exercise or treatment with antidepressant medications leads...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.09.003
更新日期：2007-09-29 00:00:00
abstract：:The gastric mucosa is frequently exposed to different exogenous and endogenous ulcerative agents. Alcoholism is one of the risk factors for the development of mucosal damage in the stomach. This study aimed to assess if a probiotic strain Lactobacillus rhamnosus GG (LGG) is capable of protecting the gastric mucosa fro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.03.018
更新日期：2007-05-16 00:00:00
abstract：AIMS:Ginsenoside-Rg1 (G-Rg1), a saponin that is a primary component of ginseng, is very useful and important in traditional Chinese medicine for stroke. The objective of this study was to explore the mechanisms underlying the neuroprotective effect of G-Rg1 on focal cerebral ischemia/reperfusion. MAIN METHODS:Focal ce...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.12.002
更新日期：2015-01-15 00:00:00
abstract：:Relationship between in vivo down-regulation of cardiac muscarinic receptors and changes in their encoding mRNA was investigated. Rats were treated either once or for ten days with an irreversible inhibitor of acetylcholinesterase, followed by measurements of cardiac acetylcholinesterase, the density and affinity of m...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90615-i
更新日期：1991-01-01 00:00:00
abstract：:Recent studies suggest that protein kinase C and, thus, possibly the rate of inositol phospholipid hydrolysis may regulate the function and distribution of the asialoglycoprotein (or galactosyl) receptor on isolated rat hepatocytes (Takahashi et al., Biochem. Biophys. Res. Commun., 1985, 126, 1054; Fallon and Schwartz...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90110-0
更新日期：1989-01-01 00:00:00
abstract：AIMS:Dyslipidemia-associated diabetic retinopathy is featured by macular edema and retinal angiogenesis. This study investigated the in vitro lipotoxicity of free fatty acids and their modulatory roles in regulation of autophagy and angiogenic factor production in cultured human retinal pigment epithelium (RPE) ARPE-19...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118391
更新日期：2020-10-15 00:00:00
abstract：:The present study was to test whether the recently described endogenous ligand for the cannabinoid receptor; arachidonyl-ethanolamide (anandamide, ANA), may produce similar effects on pregnancy as the main psychoactive component of marihuana: delta9-tetrahydrocannabinol (THC) in rats. ANA, THC (0.02 mg/kg i.p./day, re...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00296-8
更新日期：1997-01-01 00:00:00
abstract：:Beriberi is a disease caused by thiamine deficiency (TD), which may lead to heart problems, including heart failure. Despite the fact that thiamine prevalence is reduced in the industrialized world, it remains a health hazard especially due to chronic alcohol consumption. Diagnosing the presence of TD based on both el...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2013.12.029
更新日期：2014-03-07 00:00:00
abstract：:Many hormones are known to induce the activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme for polyamine biosynthesis, in their target tissues. Using ovariectomized rats, we have compared the effects of sex hormones on ODC activity in the uterus and the kidney which contain estrogen and androg...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90219-h
更新日期：1990-01-01 00:00:00
abstract：AIM:Cadmium is a persistent ubiquitous environmental toxicant that elicits several biological defects on delicate body organs. Growing evidence suggests that cadmium (Cd) may perturb signaling pathways to induce oxidative pancreatitis. Thus, we explored whether hesperidin, a flavonone, could mitigate Cd-induced oxidati...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118268
更新日期：2020-10-15 00:00:00
abstract：AIMS:Electromagnetic fields (EMFs) can act as inducers or mediators of stress response through the production of heat shock proteins (HSPs) that modulate immune response and thymus functions. In this study, we analyzed cellular stress levels in rat thymus after exposure of the rats to a 2.45 GHz radio frequency (RF) us...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.01.027
更新日期：2015-04-15 00:00:00
abstract：:Melanin in the skin determines the skin color, and decreased melanin causes many hypopigmentation disorders and increased damage to skin by ultraviolet B (UVB) light irradiation. Here, we stimulate melanogenesis in B16F10 melanoma cells by using specific frequencies of ELF-EMFs. In this study, we focus on the melanoge...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.08.015
更新日期：2016-10-01 00:00:00
abstract：:This report documents studies on the spontaneous reactivation of human erythrocyte acetylcholinesterase and human serum butyrylcholinesterase following inhibition by organophosphinate esters. The spontaneous reactivation reactions were carried out at 26.0 degrees C in 0.10 M phosphate buffer of pH 7.6. Based upon resu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90553-3
更新日期：1985-05-06 00:00:00
abstract：:The effect of moxisylyte hydrochloride on isolated human penile corpus cavernosum tissue was investigated and compared with other a-adrenergic antagonists. Moxisylyte produced a concentration-dependent relaxation of a norepinephrine-induced (1 x 10(-5) M) contraction of the corpus cavernosum tissue. Pretreatment with ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90194-x
更新日期：1989-01-01 00:00:00
abstract：:PNA+Tempol, albumin containing conjugated (polynitroxyl albumin; PNA) and free (4-hydroxyl-2,2,6,6-tetramethyl-piperidinyl-1-oxyl; Tempol) nitroxide may protect against injury caused by reactive oxygen species. Therefore, the actions of PNA+Tempol on liver injury and inflammation induced by hepatic ischemia and reperf...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00907-3
更新日期：2000-11-17 00:00:00
