Chronic cigarette sidestream smoke exposure increases rat trachea ornithine decarboxylase activity.

abstract：:Using Sokoloff's 2-deoxyglucose (2-DG) autoradiographic technique, the psychotomimetic drug, phencyclidine (PCP, "angel dust") dramatically increased metabolism in diencephalic and telencephalic brain regions known to be rich in high affinity PCP receptors. These effects were greatest in the limbic circuit described i...

journal_title：Life sciences

authors： Piercey MF,Ray CA

更新日期：1988-01-01 00:00:00

abstract：AIMS:Considering the implications that arose from several recent experimental studies using recombinant human erythropoietin in rodents, erythropoietin has been regarded as a pharmacological preconditioning agent. The purpose of the present study was to evaluate whether erythropoietin has a preconditioning effect again...

journal_title：Life sciences

authors： Sayan H,Ozacmak VH,Sen F,Cabuk M,Atik DY,Igdem AA,Ozacmak ID

更新日期：2009-03-13 00:00:00

abstract：:Chromatin organization was examined in confluent cultures of embryonic lung fibroblasts in the middle and at the end of their replicative lifespan. Age-related modifications resulted in an unusually wide spacing of the chromatin threads induced by a mild loosening treatment and an increased sensitivity of the nucleoso...

journal_title：Life sciences

authors： Puvion-Dutilleul F,Puvion E,Macieira-Coelho A

更新日期：1983-06-13 00:00:00

abstract：:First isolated some 10 years ago as the endogenous ligand for the "orphan opioid receptor" (ORL-1, now designated NOP), nociceptin/orphanin FQ (N/OFQ) has proved to be a potent inhibitory neuropeptide found across the neuraxis. Because of the homologies between opioids and N/OFQ, functional studies of this peptide hav...

journal_title：Life sciences

authors： Heinricher MM

更新日期：2005-11-04 00:00:00

abstract：:Kinin release and its involvement in inflammatory exudation were assessed by immuno-blot analysis of the kinin-precursor protein, high molecular weight kininogen (HK). HK consists of heavy (H) chain, bradykinin and light (L) chain. After bradykinin was released by plasma kallikrein, HK remains two-chain-kinin-free for...

journal_title：Life sciences

authors： Fujie H,Hayashi I,Oh-ishi S

更新日期：1993-01-01 00:00:00

abstract：:The potential photoaffinity ligand 14-beta-(o-nitro, p-azido)-cinnamoyl-amino-N-cyclopropylmethylnormorphinone (NAM) and its derivative NOM, lacking the p-azido function, were synthesised and their opiate receptor activity determined in isolated tissue preparations. The ligands showed slow receptor kinetics. NAM was a...

journal_title：Life sciences

authors： Peers EM,Rance MJ,Barnard EA,Haynes AS,Smith CF

更新日期：1983-01-01 00:00:00

abstract：:Involvement of a central histaminergic mechanism in the stimulating effect of beta-endorphin (beta-End) on the pituitary-adrenocortical activity, measured indirectly through corticosterone secretion, was investigated in conscious rats. The rise in serum corticosterone levels, induced by beta-End injected intraventricu...

journal_title：Life sciences

authors： Turoń M,Tytoń J,Bugajski J

更新日期：1991-01-01 00:00:00

abstract：:Withania somnifera (ashwagandha, Indian ginseng) is an immunostimulant herbal medicine used to improve overall health and prevent diseases, particularly in the elderly. However, the mechanisms underlying its immunostimulant effect is poorly understood. To elucidate the mechanism of Withania somnifera, we investigated ...

journal_title：Life sciences

authors： Iuvone T,Esposito G,Capasso F,Izzo AA

更新日期：2003-02-21 00:00:00

abstract：:A phase 1, randomized, double-blind, placebo-controlled, dose escalation study of the purine derivative, AIT-082 (Neotrofin, NeoTherapeutics) was conducted in mild Alzheimer's disease (AD) patients to evaluate multiple-dose safety, tolerability, and pharmacokinetics. Possible short-term effects of AIT-082 on cognition...

journal_title：Life sciences

authors： Grundman M,Capparelli E,Kim HT,Morris JC,Farlow M,Rubin EH,Heidebrink J,Hake A,Ho G,Schultz AN,Schafer K,Houston W,Thomas R,Thal LJ,Alzheimer's Disease Cooperative Study.

更新日期：2003-06-20 00:00:00

abstract：:We assessed the anxiolytic effect of Kami-Shoyo-San (Jia-wei-xiao-yao-san; TJ-24), one of a traditional Chinese herbal medicine used for the treatment of menopausal anxiety, by the social interaction (SI) test in male mice. Acute administration of TJ-24 (25-100 mg/kg, p.o.), as well as the gamma-amino-butyric acidA/be...

journal_title：Life sciences

authors： Mizowaki M,Toriizuka K,Hanawa T

更新日期：2001-09-21 00:00:00

abstract：:Excessive fibrosis and extracellular matrix deposition resulting from upregulation of target genes expression mediated by transforming growth factor-beta (TGF-β)/SMAD and hypoxia inducible factor-1 (HIF-1) signaling pathways are the main mechanisms that drive keloid formation. Sumoylation is a protein posttranslationa...

journal_title：Life sciences

authors： Lin X,Wang Y,Jiang Y,Xu M,Pang Q,Sun J,Yu Y,Shen Z,Lei R,Xu J

更新日期：2020-08-15 00:00:00

abstract：:The effects of 1,3-dipropyl-8(p-sulfophenyl)xanthine (DPSPX) and enprofylline on the respiratory responses to bilateral occlusions of the common carotid arteries (CCO) were studied in rats anesthetized with sodium pentobarbitone and breathing spontaneously. CCO during periods of 5, 10 and 15 s caused increases in tida...

journal_title：Life sciences

authors： Monteiro EC,Ribeiro JA

更新日期：1989-01-01 00:00:00

abstract：:Morphine and the enkephalin-like peptide FK 33-824 given i.p. to rats potently inhibit gastrointestinal transit of a charcoal test meal, the doses inhibiting transit by 50% being respectively about 10 and 1 microgram/kg. These intestinal effects are opiate-specific, locally elicited and presumably involve the same act...

journal_title：Life sciences

authors： Manara L,Bianchi G,Fiocchi R,Notarnicola A,Peracchia F,Tavani A

更新日期：1982-09-20 00:00:00

abstract：AIMS:β-Adrenoceptors (β-ADRs) mediating the relaxation of rat superior mesenteric arteries (SMAs) were pharmacologically identified, and the effects of chemical sympathetic denervation on β-ADR-mediated relaxation were examined. MAIN METHODS:The tension changes of endothelium-denuded SMAs were isometrically recorded a...

journal_title：Life sciences

authors： Obara K,Shigematsu M,Takahasi H,Iiboshi Y,Yoshioka K,Kasuya Y,Tanaka Y

更新日期：2020-01-15 00:00:00

abstract：AIMS:In myocardial ischemia-reperfusion (MI/R) injury, impaired autophagy function worsens cardiomyocyte death. AMP-activated protein kinase (AMPK) is a heterotrimeric protein that plays an important role in cardioprotection and myocardial autophagic function. AMPKα1 and α2 are localized primarily in the cytoplasm and ...

journal_title：Life sciences

authors： Wang Y,Yang Z,Zheng G,Yu L,Yin Y,Mu N,Ma H

更新日期：2019-05-15 00:00:00

abstract：:Using electric eel acetylcholinesterase (AChE) which was either membrane-bound (AChEm) or solubilized (AChEs), similar kinetics were seen in the absence of inhibitor or in the presence of edrophonium, trimethylammonium ion or paraoxon. Thus, both forms of the enzyme appear to behave similarly toward various inhibitors...

journal_title：Life sciences

authors： Lenz DE,Maxwell DM,Walden MB

更新日期：1984-01-16 00:00:00

abstract：:To investigate whether endogenous opioid peptides mediate time-dependent changes in ventilatory control during prolonged hypoxia, we studied four adult goats at rest during 14 days at simulated high altitude in a hypobaric chamber (PB approximately 450 Torr). Arterial PCO2 fell during the first several hours of hypoxi...

journal_title：Life sciences

authors： Weinberger SE,Steinbrook RA,Carr DB,Fencl V,Gabel RA,Leith DE,Fisher JE,Harris R,Rosenblatt M

更新日期：1987-02-16 00:00:00

abstract：:To elucidate the pharmacological profile of P2X receptors and the probable expression of P2Y receptors in otic ganglion neurons from 17-day-old rats, single neurons were enzymatically isolated and maintained in tissue culture for up to 30 h. Whole-cell voltage-clamp recording was carried out at a holding potential of ...

journal_title：Life sciences

authors： Ma B,Yu LH,Fan J,Ni X,Burnstock G

更新日期：2008-08-01 00:00:00

abstract：:Vanadate has been suggested as an intracellular regulator of (Na+ + K+)-ATPase. To test this hypothesis we examined the stimulatory and inhibitory effects of vanadate on 86--Rb efflux and influx (measurements of the activity of the Na-pump) in rat ileum under conditions of normal, reduced and increased (Na+ + K+)-ATPa...

journal_title：Life sciences

authors： Hajjar JJ,Rowe WA,Tomicic TK

更新日期：1988-01-01 00:00:00

abstract：AIMS:Ovarian cancer (OC) is the most lethal gynecologic malignant tumors all over the world. HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) has been reported as an important regulator in multiple tumors. However, the functions of HOTAIRM1 in OC and its possible molecular mechanisms remain unclear. MAIN METHODS:qRT-...

journal_title：Life sciences

authors： Chao H,Zhang M,Hou H,Zhang Z,Li N

更新日期：2020-02-15 00:00:00

abstract：:In vitro effects of medicinal plant extracts from the pericarpium of Citrus reticulata (cv Jiao Gan) (PCRJ) on the growth and differentiation of a recently characterized murine myeloid leukemic cell clone WEHI 3B (JCS) were investigated. Extracts of PCRJ not only inhibited the proliferation of JCS cells in a dose depe...

journal_title：Life sciences

authors： Mak NK,Wong-Leung YL,Chan SC,Wen J,Leung KN,Fung MC

更新日期：1996-01-01 00:00:00

abstract：:[3H] Dynorphin can be shown to bind to the brains of both rat and guinea pigs with approximately 50% specific binding. Characterization of the binding in terms of multiple opiate receptor types supports the kappa selectivity of dynorphin in guinea pig. However, in rat brain, a substantial proportion of the [3H] dynorp...

journal_title：Life sciences

authors： Young E,Walker JM,Houghten R,Akil H

更新日期：1983-01-01 00:00:00

abstract：AIMS:In our model, we aimed to explore the cytotoxicity of 5-Aza-2'-deoxycytidine (5-Aza-CdR) against the colorectal cell line, Lovo, and further characterize the possible mechanisms. MAIN METHODS:After Lovo cells were treated with 5-Aza-CdR at different concentrations for different periods of time, the cell viability...

journal_title：Life sciences

authors： Deng T,Zhang Y

更新日期：2009-02-27 00:00:00

abstract：:The aim of this study was to examine the distribution of dopamine and norepinephrine in the proximal alimentary tract of the rat and to assess the contributions of sympathetic and vagal fibers to the tissue concentrations of both catecholamines. Tissues were extracted in perchloric acid and the catecholamines were sep...

journal_title：Life sciences

authors： Orloff LA,Orloff MS,Bunnett NW,Walsh JH

更新日期：1985-04-29 00:00:00

abstract：:In the present study, we investigated the effects of calmodulin, adenosine 5'-triphosphate (ATP) and pertussis toxin (PT) on phorbol ester (PMA) (a protein kinase C activator) induced inhibition of ANF-stimulated cyclic GMP formation in cells from the human renal cell line, SK-NEP-1. PMA inhibited ANF-stimulated guany...

journal_title：Life sciences

authors： Sekiya M,Frohlich ED,Cole FE

更新日期：1991-01-01 00:00:00

abstract：:By using multiple time-point constant-rate infusions of deuterium-labeled phosphorylcholine, appropriate kinetic parameters were obtained for use in the calculation of the turnover rate of acetylcholine (TRACh) in selected mouse brain regions. After obtaining these data, the relationship between the analgesic agent co...

journal_title：Life sciences

authors： Chen R,Robinson SE

更新日期：1992-01-01 00:00:00

abstract：:Recent studies on video game playing have uncovered a wide range of measurable physiological effects on the organism, such as increases in cardiovascular activity and breathing responses. However, the exact source of these effects remains unclear. Given the well-known effects of sound on physiological activity, especi...

journal_title：Life sciences

authors： Hébert S,Béland R,Dionne-Fournelle O,Crête M,Lupien SJ

更新日期：2005-04-01 00:00:00

abstract：:We measured the concentration of immunoreactive (IR) hEGF in various body fluids by radioimmunoassay (RIA) and evaluated its size heterogeneity by size exclusion high performance liquid chromatography combined with RIA or with time-resolved immunofluorometric assay (TR-IFMA). Mean concentration was 80 ng/ml in urine, ...

journal_title：Life sciences

authors： Pesonen K,Viinikka L,Koskimies A,Banks AR,Nicolson M,Perheentupa J

更新日期：1987-06-29 00:00:00

abstract：AIMS:The aim of the present study was to characterize TRPV4 channels in pregnant and nonpregnant mouse uterus and examine their functional role in spontaneous and agonist-induced contractions. MAIN METHODS:We used RT-PCR, Western blot and immunohistochemistry experiments to demonstrate the presence of TRPV4 mRNA and p...

journal_title：Life sciences

authors： Singh V,Ram M,Kandasamy K,Thangamalai R,Choudhary S,Dash JR,Kumar D,Parida S,Singh TU,Mishra SK

更新日期：2015-02-01 00:00:00

abstract：:Administration of a high dose of hydrocortisone hemisuccinate sodium (0.25 mumol/egg) to 15-day-old fertilized hen's eggs caused accumulation of biliverdin in the embryonic liver. The responses were 10 to 20-fold higher than controls within 48 hr as a result of stimulation of biliverdin synthesis in the liver and the ...

journal_title：Life sciences

authors： Nishigori H,Ishida O,Ogihara-Umeda I

更新日期：1993-01-01 00:00:00