Preventive effect of pyrroloquinoline quinone (PQQ) on biliverdin accumulation of the liver of chick embryo after glucocorticoid administration.

abstract：:Gloriosaols A-C, isolated from Yucca gloriosa (Agavaceae), are novel phenolic compounds structurally related to resveratrol. In the present study, we show that gloriosaols possess antiproliferative and pro-apoptotic activity on tumor cells of different histogenetic origin and that their cell growth inhibition potentia...

journal_title：Life sciences

authors： Nigro P,Bloise E,Turco MC,Skhirtladze A,Montoro P,Pizza C,Piacente S,Belisario MA

更新日期：2007-08-23 00:00:00

abstract：:The present study investigated the protective actions of the antioxidant scutellarin against the cytotoxicity produced by exposure to H2O2 in PC12 cells. This was done by assaying for MTT (3,(4,5-dimethylthiazole-2-yl)2,5-diphenyl-tetrazolium bromide) reduction and lactate dehydrogenase (LDH) release. Reactive oxygen ...

journal_title：Life sciences

authors： Hong H,Liu GQ

更新日期：2004-04-30 00:00:00

abstract：:Progesterone's (P) actions in the ventral medial hypothalamus (VMH) and the ventral tegmental area (VTA) are essential for sexual receptivity in hamsters. This study investigates the notion that P works in the VTA in the absence of intracellular P receptors (PRs) by 5 alpha-reduction to progestins, which would subsequ...

journal_title：Life sciences

authors： Frye CA,Leadbetter EA

更新日期：1994-01-01 00:00:00

abstract：UNLABELLED:The present study was conducted to examine whether melatonin impairs serotonin (5HT) release and uptake in rat platelets. Exposure of platelet-rich plasma samples (PRP) to melatonin induced a concentration-dependent inhibition of 5HT uptake and the value of IC50 was 1.3 x 10(-3) M. We have also investigated ...

journal_title：Life sciences

authors： Martín FJ,Atienza G,Aldegunde M,Míguez JM

更新日期：1993-01-01 00:00:00

abstract：:As the relationship between emotional behavior and electrocardiographic (ECG) change induced by hypothalamic stimulation is poorly understood, eighty-four points in various areas within the hypothalamus in conscious cats were stimulated electrically through chronically implanted electrodes, the objective being to clar...

journal_title：Life sciences

authors： Tashiro N,Tanaka T,Fukumoto T,Hirata K,Nakao H

更新日期：1985-03-18 00:00:00

abstract：:Of primary interest for every enzyme is the identification of its physiological substrates. However, the vast structural diversity of endogenous metabolites, coupled with the overlapping activities of numerous enzymes, makes it difficult to deduce the identity of natural substrates for a given enzyme based on in vitro...

journal_title：Life sciences

authors： Saghatelian A,Cravatt BF

更新日期：2005-08-19 00:00:00

abstract：:The effects of pyrroloquinoline quinone (PQQ) and PQQ-oxazole (PQQ-glycine adduct) on DNA synthesis were examined using cultured human fibroblasts. Confluent fibroblasts were cultured in serum-free Dulbecco's modified Eagle's media, and various concentrations of PQQ and PQQ-oxazole were added to the media. After incub...

journal_title：Life sciences

authors： Naito Y,Kumazawa T,Kino I,Suzuki O

更新日期：1993-01-01 00:00:00

abstract：:When s-triazolo[3,4-a]phthalazine (Tri-P) was orally administered in rats, a more lipophilic metabolite M-1 than the parent compound was isolated from the urine. The metabolite M-1 was identified as 7-methylthio Tri-P by means of high resolution MS and two-dimensional NMR spectrometry. Furthermore, the 7-methylthio co...

journal_title：Life sciences

authors： Imamura Y,Noda A,Imamura T,Ono Y,Okawara T,Noda H

更新日期：2003-11-21 00:00:00

abstract：:Drug-induced refractoriness of alpha-adrenergic receptor-mediated vasoconstriction may be a clinically important phenomenon. We have investigated the possible molecular mechanisms underlying this phenomenon in cultured vascular smooth muscle cells derived from the rabbit aorta. alpha 1-Adrenergic receptors were identi...

journal_title：Life sciences

authors： Wikberg JE,Akers M,Caron MG,Hagen PO

更新日期：1983-10-03 00:00:00

abstract：:NMDA receptors are glutamate-regulated ion channels of critical importance for many neurophysiological and neuropathological processes. Mg2+ blocks the NMDA receptor by binding to the channel pore with an apparent affinity that depends on the membrane potential. We have investigated the effect of NMDA and the required...

journal_title：Life sciences

authors： Liu Y,Hill RH,Arhem P,von Euler G

更新日期：2001-03-09 00:00:00

abstract：UNLABELLED:Based on preclinical findings, cellular therapy has become a promising therapeutic approach for neonatal hypoxia-ischemia (HI). However, before translation into the clinical setting, new and effective routes of cell delivery must be determined. Intra-arterial (IA) delivery is an attractive route of cellular ...

journal_title：Life sciences

authors： Greggio S,de Paula S,Azevedo PN,Venturin GT,Dacosta JC

更新日期：2014-02-06 00:00:00

abstract：AIMS:The clinical efficiency of dendritic cell (DC) therapy needs to be improved. Exosomes, as membrane nano-vesicles, carry bio-macromolecules and play essential roles in intercellular crosstalk. Here, it is proposed that tumor cell-derived exosomes could function as vehicles to deliver exogenous miRNA-155 into DCs, f...

journal_title：Life sciences

authors： Asadirad A,Hashemi SM,Baghaei K,Ghanbarian H,Mortaz E,Zali MR,Amani D

更新日期：2019-02-15 00:00:00

abstract：:The purpose of this study was to examine whether the adhesion of polymorphonuclear leukocytes (PMNs) to endothelial cells and/or reactive oxygen species (ROS) released from PMNs are responsible for inducing angiogenesis. Angiogenesis was assessed by tube formation using endothelial cells obtained from bovine thoracic ...

journal_title：Life sciences

authors： Yasuda M,Shimizu S,Tokuyama S,Watanabe T,Kiuchi Y,Yamamoto T

更新日期：2000-04-14 00:00:00

abstract：:We investigated the inhibition of human cholinesterases by galanthamine, an alkaloid of the common snowdrop (galanthus nivalis). In vitro, the compound showed potent enzyme inhibition and 50-fold selectivity for acetylcholinesterase (EC 3.1.1.7) as opposed to butyrylcholinesterase (EC 3.1.1.8). There was no difference...

journal_title：Life sciences

authors： Thomsen T,Kewitz H

更新日期：1990-01-01 00:00:00

abstract：:This work analyzes the 24-hour changes of hypothalamic-pituitary-adrenal (HPA) axis activity and leptin release in aged rats. Three- and 22-month-old male Wistar rats were killed at 6 time intervals during a 24-hour cycle (n=8-10 rats/group). Aging augmented plasma ACTH while it decreased plasma and adrenal gland cort...

journal_title：Life sciences

authors： Cano P,Cardinali DP,Spinedi E,Esquifino AI

更新日期：2008-07-18 00:00:00

abstract：:In canine renal tubular cells, the effect of Y-24180, a presumed specific platelet activating factor (PAF) receptor antagonist, on intracellular Ca(2+) concentration ([Ca(2+)](i)) was measured by using fura-2 as a Ca(2+)-sensitive fluorescent probe. Y-24180 (0.1-10 microM) caused a rapid and sustained [Ca(2+)](i) rise...

journal_title：Life sciences

authors： Chao YY,Jan CR

更新日期：2004-01-02 00:00:00

abstract：AIMS:The mechanism of cough hypersensitivity induced by particulate matter 2.5 (PM2.5) remains elusive. The current study was designed to explore the effect of transient receptor potential vanilloid-1 (TRPV1) on cough hypersensitivity in airway and central nervous system. MAIN METHODS:The PM2.5-induced chronic cough m...

journal_title：Life sciences

authors： Lv H,Yue J,Chen Z,Chai S,Cao X,Zhan J,Ji Z,Zhang H,Dong R,Lai K

更新日期：2016-04-15 00:00:00

abstract：:The present study was designed to investigate the effect of partial (two-thirds) hepatectomy (PH) on hepatic and intestinal glutathione S-transferases (GSTs) activities. A significant decrease of cytosolic hepatic GSTs activity was observed after the PH. The lowest value of hepatic GSTs was obtained 48 h after the sur...

journal_title：Life sciences

authors： Carnovale CE,Monti JA,Favre C,Scapini C,Carrillo MC

更新日期：1995-01-01 00:00:00

abstract：AIMS:We evaluated if selected pro-inflammatory cytokines and/or the protein suppressor of cytokine signaling 3 (SOCS-3) could account for decreased insulin-stimulated phosphatidylinositol 3-kinase (PI3-K) activity in the skeletal muscle of the obese Zucker rat. MAIN METHODS:Eight lean and eight obese Zucker rats ~4wee...

journal_title：Life sciences

authors： Zolotnik IA,Figueroa TY,Yaspelkis BB 3rd

更新日期：2012-10-22 00:00:00

abstract：:Ketamine, used clinically as an intravenous analgetic and dissociative anaesthetic agent, is a racemate with both pharmacokinetic and pharmacodynamic enantioselectivity. S-ketamine has been found have a higher clearance and greater potency than R-ketamine as well as a greater therapeutic index. We performed a study in...

journal_title：Life sciences

authors： Edwards SR,Mather LE

更新日期：2001-09-14 00:00:00

abstract：:It has been suggested that dopamine might play a role in the regulation of the immune system. In this study, reverse transcriptase-polymerase chain reaction (RT-PCR) was used to investigate the expression of mRNA for the different subtypes of dopamine receptors in the rat lymphocytes. D1, D3 and D5 receptor mRNAs were...

journal_title：Life sciences

authors： Caronti B,Calderaro C,Passarelli F,Palladini G,Pontieri FE

更新日期：1998-01-01 00:00:00

abstract：:We examined the effects of arginine-vasopressin (AVP) C-terminal fragment 4-9, which facilitates learning and memory, on the extracellular acetylcholine (ACh) release in hippocampus of freely-moving rats using the microdialysis technique. Following administration of AVP4-9, p-Glu-Asn-Cys[Cys]-Pro-Arg-Gly-NH2, through ...

journal_title：Life sciences

authors： Maegawa H,Katsube N,Okegawa T,Aishita H,Kawasaki A

更新日期：1992-01-01 00:00:00

abstract：:TCDD was assessed as a biological response modifier for increasing MMC cytotoxicity through aryl hydrocarbon receptor (AhR) activation and increasing levels of bioreductive enzymes. Human MCF-7 cells were exposed to TCDD, MMC and combinations thereof under aerobic or hypoxic conditions. Cytotoxicity, enzyme activities...

journal_title：Life sciences

authors： Collier AC,Pritsos KL,Pritsos CA

更新日期：2006-02-23 00:00:00

abstract：:The effects of two benzodiazepine derivatives (diazepam, 0.5-1 mg/kg; alprazolam, 1.25-2.5 mg/kg) on ultrasonic calling elicited in adult rats by unavoidable aversive stimuli (footshocks) were investigated. The results show that either diazepam or alprazolam affected the duration of ultrasonic calls. In particular, a ...

journal_title：Life sciences

authors： Cuomo V,Cagiano R,De Salvia MA,Maselli MA,Renna G,Racagni G

更新日期：1988-01-01 00:00:00

abstract：AIMS:Cardiovascular disease is the leading cause of death for individuals diagnosed with type II diabetes mellitus (DM). Changes in cardiac function, left ventricular wall thickness and fibrosis have all been described in patients and animal models of diabetes; however, the factors mediating increased matrix deposition...

journal_title：Life sciences

authors： Fowlkes V,Clark J,Fix C,Law BA,Morales MO,Qiao X,Ako-Asare K,Goldsmith JG,Carver W,Murray DB,Goldsmith EC

更新日期：2013-03-28 00:00:00

abstract：:Recent studies suggest that protein kinase C and, thus, possibly the rate of inositol phospholipid hydrolysis may regulate the function and distribution of the asialoglycoprotein (or galactosyl) receptor on isolated rat hepatocytes (Takahashi et al., Biochem. Biophys. Res. Commun., 1985, 126, 1054; Fallon and Schwartz...

journal_title：Life sciences

authors： Medh JD,Haynes PA,Weigel PH,LaBelle EF

更新日期：1989-01-01 00:00:00

abstract：AIM:Diabetic nephropathy is the leading cause of end stage renal disease in developed countries throughout the world. The imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system is the main problem that is responsible for the progression of diabetic kidney disease. In this s...

journal_title：Life sciences

authors： Kuo CW,Shen CJ,Tung YT,Chen HL,Chen YH,Chang WH,Cheng KC,Yang SH,Chen CM

更新日期：2015-08-15 00:00:00

abstract：:Clinical trials with muscarinic agonists or acetylcholine esterase inhibitors for the treatment of Alzheimer's dementia have shown disappointing or equivocal results. An alternative treatment of this disease is the development of drugs which enhance the release of acetylcholine. It is believed, that of the five muscar...

journal_title：Life sciences

authors： Doods HN,Quirion R,Mihm G,Engel W,Rudolf K,Entzeroth M,Schiavi GB,Ladinsky H,Bechtel WD,Ensinger HA

更新日期：1993-01-01 00:00:00

abstract：:The present study was performed to determine if the attenuated pressor response to vasopressin in conscious non-estrous female rats is due in part to an enhanced V2-like receptor vasodilator action. In male rats, infusion of vasopressin at a rate of 1 ng.min(-1).kg body weight-1 (wt) resulted in an increase in mean ar...

journal_title：Life sciences

authors： Wang YX,Crofton JT,Liu H,Sato K,Share L

更新日期：1996-01-01 00:00:00

abstract：:A mechanism of antidepressant activity of beta-amyrin palmitate was studied using the forced swimming method in mice. Beta-amyrin palmitate (10 mg/kg) reduced the increase in the duration of immobility induced by tetrabenazine (100 and 200 mg/kg), but showed no effect on that in mice treated with alpha-methyl-para-tyr...

journal_title：Life sciences

authors： Subarnas A,Tadano T,Nakahata N,Arai Y,Kinemuchi H,Oshima Y,Kisara K,Ohizumi Y

更新日期：1993-01-01 00:00:00