Abstract：
:Clinical trials with muscarinic agonists or acetylcholine esterase inhibitors for the treatment of Alzheimer's dementia have shown disappointing or equivocal results. An alternative treatment of this disease is the development of drugs which enhance the release of acetylcholine. It is believed, that of the five muscarinic receptor subtypes so far identified in the brain, M2 receptors are located presynaptically in the cortex and hippocampus and upon stimulation inhibit the release of acetylcholine. Based on this hypothesis, we initiated a drug discovery program with the aim of identifying selective and centrally active M2 antagonists which are capable of enhancing cholinergic transmission. These efforts resulted in the successful design and synthesis of novel muscarinic antagonists able to cross the blood brain barrier. Moreover, these compounds show few peripheral effects and possess a superior M2 versus M1 selectivity. The prototype of this novel class of M2 selective compounds, BIBN 99, could be a valuable tool to test the hypothesis that lipophilic M2 antagonists show beneficial effects in the treatment of cognitive disorders.
journal_name
Life Scijournal_title
Life sciencesauthors
Doods HN,Quirion R,Mihm G,Engel W,Rudolf K,Entzeroth M,Schiavi GB,Ladinsky H,Bechtel WD,Ensinger HAdoi
10.1016/0024-3205(93)90307-osubject
Has Abstract,Author List Incompletepub_date
1993-01-01 00:00:00pages
497-503issue
5-6eissn
0024-3205issn
1879-0631pii
0024-3205(93)90307-Ojournal_volume
52pub_type
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