Abstract:
:The expression of the corticotropin-releasing hormone (CRH) gene and the arginine vasopressin (AVP) gene in the hypothalamus examined in bilateral nephrectomized rats by in situ hybridization histochemistry. The expression of the CRH gene was significantly increased in the parvocellular part of the paraventricular nucleus (PVN) 12 and 20 h after bilateral nephrectomy in comparison with that after sham operation. The plasma concentration of adrenocorticotropic hormone (ACTH) in nephrectomized rats was significantly higher than that in sham operated rats 20 h after surgery. In contrast, the expression of the AVP gene in both the parvocellular and magnocellular parts of the PVN and throughout the supraoptic nucleus (SON) was significantly decreased 20 h after bilateral nephrectomy in comparison with that after sham operation. These results suggest that nephrectomy-induced upregulation of the CRH gene with elevation of plasma ACTH may be due to the activation of the hypothalamo-pituitary adrenal (HPA) axis.
journal_name
Life Scijournal_title
Life sciencesauthors
Nomura M,Serino R,Yamamoto Y,Ozaki Y,Saito J,Matsumoto T,Yamashita H,Ueta Ydoi
10.1016/s0024-3205(02)02287-7subject
Has Abstractpub_date
2002-12-20 00:00:00pages
501-9issue
4-5eissn
0024-3205issn
1879-0631pii
S0024320502022877journal_volume
72pub_type
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