Upregulation of CRH gene expression and downregulation of arginine vasopressin gene expression in the hypothalamus of bilateral nephrectomized rats.

Abstract:

:The expression of the corticotropin-releasing hormone (CRH) gene and the arginine vasopressin (AVP) gene in the hypothalamus examined in bilateral nephrectomized rats by in situ hybridization histochemistry. The expression of the CRH gene was significantly increased in the parvocellular part of the paraventricular nucleus (PVN) 12 and 20 h after bilateral nephrectomy in comparison with that after sham operation. The plasma concentration of adrenocorticotropic hormone (ACTH) in nephrectomized rats was significantly higher than that in sham operated rats 20 h after surgery. In contrast, the expression of the AVP gene in both the parvocellular and magnocellular parts of the PVN and throughout the supraoptic nucleus (SON) was significantly decreased 20 h after bilateral nephrectomy in comparison with that after sham operation. These results suggest that nephrectomy-induced upregulation of the CRH gene with elevation of plasma ACTH may be due to the activation of the hypothalamo-pituitary adrenal (HPA) axis.

journal_name

Life Sci

journal_title

Life sciences

authors

Nomura M,Serino R,Yamamoto Y,Ozaki Y,Saito J,Matsumoto T,Yamashita H,Ueta Y

doi

10.1016/s0024-3205(02)02287-7

subject

Has Abstract

pub_date

2002-12-20 00:00:00

pages

501-9

issue

4-5

eissn

0024-3205

issn

1879-0631

pii

S0024320502022877

journal_volume

72

pub_type

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