Dopamine receptor mRNAs in the rat lymphocytes.

abstract：:In the present study the effects of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) on fibroblast growth and activity have been studied. In this regard the AA have evaluated in primary cultures of human gengival normal fibroblasts (PG1 cells): a)-the expression of GM-CSF receptor (GM-CSFR) (alfa unit) on the...

journal_title：Life sciences

authors： Postiglione L,Montagnani S,Riccio A,Ladogana P,Salzano S,Vallefuoco L,Rossi G

更新日期：1998-01-01 00:00:00

abstract：:Concanavalin A enhanced the rat rectal absorption of phenol red and cefoxitin at pH 7.4 and the uptake of cefoxitin into brush border membrane vesicles prepared from rat rectal membrane. The enhancing action of concanavalin A demonstrated a sodium ion dependency and was inhibited by the presence of 4,4'-diisothiocyano...

journal_title：Life sciences

authors： Nishihata T,Higuchi T

更新日期：1984-01-30 00:00:00

abstract：AIMS:Hypercholesterolemia is a hazard for increasing susceptibility of the heart to myocardial infarction (MI) by inducing platelet hyperaggregability. Clopidogrel and prasugrel have documented cardioprotective effects in clinical studies. Herein, we investigated whether clopidogrel and prasugrel could protect against ...

journal_title：Life sciences

authors： Mohammad HMF,Makary S,Atef H,El-Sherbiny M,Atteia HH,Ibrahim GA,Mohamed AS,Zaitone SA

更新日期：2020-04-15 00:00:00

abstract：AIMS:It has been shown that exposure to extremely-low frequency (˂300Hz) oscillating electromagnetic field (EMF) can affect gene expression. The effects of different exposure patterns of 50-Hz EMF and co-treatment of EMF plus cisplatin (CDDP) on mRNA levels of seven genes involved in DNA repair pathways (GADD45A, XRCC1...

journal_title：Life sciences

authors： Sanie-Jahromi F,Saadat I,Saadat M

更新日期：2016-12-01 00:00:00

abstract：AIM:Diabetic nephropathy is the leading cause of end stage renal disease in developed countries throughout the world. The imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system is the main problem that is responsible for the progression of diabetic kidney disease. In this s...

journal_title：Life sciences

authors： Kuo CW,Shen CJ,Tung YT,Chen HL,Chen YH,Chang WH,Cheng KC,Yang SH,Chen CM

更新日期：2015-08-15 00:00:00

abstract：:In this study we compared the antioxidant properties of five different extracts of different composition obtained from Achyrocline satureioides' inflorescences (Compositae), a widely used Brazilian folk medicinal herb. All of the extracts presented significant antioxidant potential identified by TRAP assay, which incr...

journal_title：Life sciences

authors： Polydoro M,de Souza KC,Andrades ME,Da Silva EG,Bonatto F,Heydrich J,Dal-Pizzol F,Schapoval EE,Bassani VL,Moreira JC

更新日期：2004-04-23 00:00:00

abstract：:After 7 years from its cloning, the transient receptor potential vanilloid type-1 (TRPV1) channel remains the sole membrane receptor mediating the pharmacological effects of the hot chilli pepper pungent component, capsaicin, and of the Euphorbia toxin, resiniferatoxin. Yet, this ion channel represents one of the most...

journal_title：Life sciences

authors： De Petrocellis L,Di Marzo V

更新日期：2005-08-19 00:00:00

abstract：:By using multiple time-point constant-rate infusions of deuterium-labeled phosphorylcholine, appropriate kinetic parameters were obtained for use in the calculation of the turnover rate of acetylcholine (TRACh) in selected mouse brain regions. After obtaining these data, the relationship between the analgesic agent co...

journal_title：Life sciences

authors： Chen R,Robinson SE

更新日期：1992-01-01 00:00:00

abstract：:Cordyceps sinensis (C. sinensis) is one of the well known fungi used in traditional Chinese medicine for treatment asthma and bronchial and lung inflammation. In this study, effects of C. sinensis methanolic extracts on bronchoalveolar lavage fluids (BALF) cells proliferation, inflammatory cytokines production, and ge...

journal_title：Life sciences

authors： Kuo YC,Tsai WJ,Wang JY,Chang SC,Lin CY,Shiao MS

更新日期：2001-01-19 00:00:00

abstract：:Aim Deformity in the cellular homeostatic event associated with cell survival and apoptosis are committing factors for carcinogenesis. Interventions of these events by pharmacologically active agent gain predominance in cancer treatment. In current investigation Solanidine, a steroidal alkaloid was evaluated on tumori...

journal_title：Life sciences

authors： Malojirao VH,Vigneshwaran V,Thirusangu P,Mahmood R,Prabhakar BT

更新日期：2018-04-15 00:00:00

abstract：AIMS:Evidence suggests that hypobaric hypoxia (HH) exposure causes biochemical and molecular level perturbations in brain resulting in associated cognitive dysfunction. However, the possible effect of HH on amygdala and the associated limbic regions based functions remains elusive. Regulated fear expression is essentia...

journal_title：Life sciences

authors： Kumari P,Roy K,Wadhwa M,Chauhan G,Alam S,Kishore K,Ray K,Panjwani U

更新日期：2020-08-01 00:00:00

abstract：:We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations. In the present study the effe...

journal_title：Life sciences

authors： Medvede AE,Abakumova OYu,Podobed OV,Tsvetkova TA,Sandler M,Glover V

更新日期：2001-08-31 00:00:00

abstract：:In order to determine whether CCl4, CBrCl3, CBr4 or CHCl3 undergo oxidative metabolism to electrophilic halogens by liver microsomes, they were incubated with liver microsomes from phenobarbital pretreated rats in the presence of NADPH and 2,6-dimethylphenol. The analysis of the reaction mixtures by capillary gas chro...

journal_title：Life sciences

authors： Mico BA,Branchflower RV,Pohl LR,Pudzianowski AT,Loew GH

更新日期：1982-01-11 00:00:00

abstract：:The NLRP3 inflammasome regulates innate immune and inflammatory responses by promoting pro-inflammatory cytokines such as IL-18 and IL-1β. NLRP3 is one of the main factors restricting the activation of the inflammasome, which is closely related to the abundance and localization of NLRP3. A substantial number of studie...

journal_title：Life sciences

authors： Ge Q,Chen X,Zhao Y,Mu H,Zhang J

更新日期：2021-02-15 00:00:00

abstract：:The dramatic activities of bradykinin and related peptides as mediators of pain, inflammation and hypotension have been intensely studied for several decades. More recently, the involvement of bradykinin in regulation of ion transport by epithelia, hormone release from endocrine organs, energy metabolism, tissue growt...

journal_title：Life sciences

authors： Burch RM,Kyle DJ

更新日期：1992-01-01 00:00:00

abstract：:Alpha(1)-adrenergic receptors are one of the three subfamilies of G protein coupled receptors activated by epinephrine and norepinephrine to control important functions in many target organs. Three human subtypes (alpha(1A), alpha(1B), alpha(1D)) are derived from separate genes and are highly homologous in their trans...

journal_title：Life sciences

authors： Hague C,Chen Z,Uberti M,Minneman KP

更新日期：2003-12-12 00:00:00

abstract：:The roles of capsaicin-sensitive sensory nerves (CPSN), endogenous nitric oxide (NO), sulfhydryls (SHs), prostaglandins (PGs) in the gastroprotection by momordin Ic, an oleanolic acid oligoglycoside isolated from the fruit of Kochia scoparia (L.) SCHRAD., on ethanol-induced gastric mucosal lesions were investigated in...

journal_title：Life sciences

authors： Matsuda H,Li Y,Yoshikawa M

更新日期：1999-01-01 00:00:00

abstract：:The changes in hepatic energy state were assessed by 31P-nuclear magnetic resonance spectroscopy (31P-MRS) and arterial ketone body ratio (AKBR) in brain dead dogs. 31P-MRS and AKBR were measured before and at 3 hours after brain death. Wiggers' shock model was employed to compare the energy metabolism during hypotens...

journal_title：Life sciences

authors： Kitai T,Tanaka A,Terasaki M,Okamoto R,Ozawa K,Morikawa S,Inubushi T

更新日期：1991-01-01 00:00:00

abstract：:The protein inhibitor of nitric oxide synthase (PIN) was independently identified as an inhibitor of nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS), and as a member of the cellular dynein light chain family, dynein light chain 8 (LC8), responsible for intracellular protein trafficking. Mast cells ...

journal_title：Life sciences

authors： McCauley SD,Gilchrist M,Befus AD

更新日期：2007-02-13 00:00:00

abstract：AIMS:Colorectal cancer (CRC) is one of the most common cancers with poor prognosis worldwide. The advent of immunotherapy has greatly improved survival in refractory patients of CRC. In this study, we aimed to identify reliable immune classification and biomarkers that predict immunotherapeutic responses in CRC patient...

journal_title：Life sciences

authors： Li M,Li W,Yang X,Wang H,Peng Y,Yin J,Lu Y,Liu L,Shang J,Zhao Q

更新日期：2020-11-15 00:00:00

abstract：:Acute effect of streptozotocin-induced diabetes on several parameters of glucose metabolism was investigated in thymus lymphocytes (thymocytes). The cells from diabetics rats accumulated in vitro about 2-fold more fructose 2,6-bisphosphate (Fru-2, 6-P2) in the presence of increasing glucose concentration than cells fr...

journal_title：Life sciences

authors： Moreno-Aurioles VR,Montaño R,Conde M,Bustos R,Sobrino F

更新日期：1996-01-01 00:00:00

abstract：:In order to better understand the mechanisms underlying the reduction in GH secretion in diabetic rats, we have characterized and measured SRIH receptors in the hypothalamus and anterior pituitary gland 5 and 9 days after induction of diabetes in the rat. Experimental diabetes was induced by an intraperitoneal injecti...

journal_title：Life sciences

authors： Pesce G,Guillaume V,Dutour A,Dadoun F,Joanny P,Steinberg J,Oliver C

更新日期：1994-01-01 00:00:00

abstract：:Aluminum (Al) is thought to be a risk factor for neurodegenerative disorders, but the molecular mechanism has been not clarified yet. In this study, we examined how a transport system handled transport of Al citrate, the major Al species in brain, and effect of Al citrate treatment on expression of the transporter and...

journal_title：Life sciences

authors： Nagasawa K,Akagi J,Koma M,Kakuda T,Nagai K,Shimohama S,Fujimoto S

更新日期：2006-05-30 00:00:00

abstract：:Bufalin, which is one of prominent components of Chinese toad venom, was found to decrease the rate of cell proliferation of mouse melanoma clone B16-F10 cells and a concomitant stimulation of expression of its melanotic phenotype. The effect of bufalin on melanogenesis included stimulation of tyrosinase activity and ...

journal_title：Life sciences

authors： Zhang L,Yoshida T,Kuroiwa Y

更新日期：1992-01-01 00:00:00

abstract：:alpha-lactorphin (Tyr-Gly-Leu-Phe) lowers blood pressure in conscious adult SHR. This tetrapeptide is originally released from milk protein alpha-lactalbumin by enzymatic hydrolysis. In order to evaluate the antihypertensive mechanisms of alpha-lactorphin, the effects of the tetrapeptide on vascular function were inve...

journal_title：Life sciences

authors： Sipola M,Finckenberg P,Vapaatalo H,Pihlanto-Leppälä A,Korhonen H,Korpela R,Nurminen ML

更新日期：2002-08-02 00:00:00

abstract：:Continuous three day administration via implanted minipumps of cocaine hydrochloride (50-450 mg/kg/day, sc and 100-250 mg/kg/day, iv) did not produce axonal degeneration in frontal agranular cortex or neostriatum that was detectable by Fink-Heimer silver staining or tyrosine hydroxylase immunolabeling. This is in cont...

journal_title：Life sciences

authors： Ryan LJ,Martone ME,Linder JC,Groves PM

更新日期：1988-01-01 00:00:00

abstract：AIMS:Ganoderma lucidum, a traditional Chinese medicine, is well known as a modulator of functions of the immune system as well as an anti-tumour agent. However, its active compounds and their molecular mechanisms of action are not well established. GLIS, a proteoglycan isolated from the fruiting body of G. lucidum, sti...

journal_title：Life sciences

authors： Zhang J,Tang Q,Zhou C,Jia W,Da Silva L,Nguyen LD,Reutter W,Fan H

更新日期：2010-11-20 00:00:00

abstract：:DHEA improves insulin sensitivity and has anti-obesity effect in animal models and men. However, the molecular mechanisms by which DHEA improves insulin action have not been clearly understood. In the present study, we examined the protein levels and phosphorylation state of insulin receptor (IR), IRS-1 and IRS-2, the...

journal_title：Life sciences

authors： Campbell CS,Caperuto LC,Hirata AE,Araujo EP,Velloso LA,Saad MJ,Carvalho CR

更新日期：2004-11-19 00:00:00

abstract：:The effects of the d- and l-isomers of pentazocine were compared to that of racemic pentazocine on contractions of the mouse isolated vas deferens. L-pentazocine inhibited electrically evoked contractions of the mouse vas deferens (MVD) in a dose-dependent manner (ID50 0.37 +/- 0.04 microM). In contrast, d-pentazocine...

journal_title：Life sciences

authors： Kinouchi K,Fukumitsu K,Takezawa J,Maeda S,Enomoto H,Kakuhari J,Yoshiya I,Inoki R

更新日期：1986-07-14 00:00:00

abstract：:The aim of this study was to assess the anxiolytic effect of berberine (abbrev. BER) using two experimental anxiety models in the mouse. In the black and white test of anxiety, berberine (100, 500 mg/kg) produced an increase in the first time entry, time spent in the white section, and total changes between two compar...

journal_title：Life sciences

authors： Peng WH,Wu CR,Chen CS,Chen CF,Leu ZC,Hsieh MT

更新日期：2004-10-01 00:00:00