当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: effects of benzodiazepines.

Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: effects of benzodiazepines.

Abstract：

:The effects of two benzodiazepine derivatives (diazepam, 0.5-1 mg/kg; alprazolam, 1.25-2.5 mg/kg) on ultrasonic calling elicited in adult rats by unavoidable aversive stimuli (footshocks) were investigated. The results show that either diazepam or alprazolam affected the duration of ultrasonic calls. In particular, a significant decrease in the length of ultrasounds was found in the group of animals treated with these benzodiazepines. The effects of diazepam were counteracted by the benzodiazepine-antagonist Ro 15-1788. On the other hand, neither a neuroleptic agent, such as haloperidol (0.5-1 mg/kg), nor an antidepressant, such as desipramine (5-10 mg/kg) influenced the parameters of ultrasonic emission in this experimental situation. The present results suggest that ultrasonic vocalization in response to unavoidable aversive stimuli could be considered as a potential new tool for studying drugs with antianxiety properties.

journal_name

Life Sci

journal_title

Life sciences

authors

Cuomo V,Cagiano R,De Salvia MA,Maselli MA,Renna G,Racagni G

doi

10.1016/0024-3205(88)90149-x

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

485-91

issue

6

eissn

0024-3205

issn

1879-0631

pii

0024-3205(88)90149-X

journal_volume

43

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Oscillatory shear stress induces the transition of EPCs into mesenchymal cells through ROS/PKCζ/p53 pathway.

    abstract：AIMS:Studies indicate that the pattern of shear stress determines the direction of endothelial progenitor cells (EPCs) differentiation. However, the mechanism remains largely unknown. Herein, we try to identify the role of oscillatory shear stress (OSS) in the transdifferentiation of EPCs into mesenchymal cells and the...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117728

    authors： Gao Y,Cui X,Wang M,Zhang Y,He Y,Li L,Li H,Zhang X,Cheng M

    更新日期：2020-07-15 00:00:00

  • A novel muscarinic receptor ligand which penetrates the blood brain barrier and displays in vivo selectivity for the m2 subtype.

    abstract：:Alzheimer's disease (AD) involves selective loss of muscarinic m2, but not m1, subtype neuroreceptors in the posterior parietal cortex of the human brain. Emission tomographic study of the loss of m2 receptors in AD is limited by the fact that there is currently no available m2-selective radioligand which can penetrat...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90161-u

    authors： Gitler MS,Cohen VI,De la Cruz R,Boulay SF,Jin B,Zeeberg BR,Reba RC

    更新日期：1993-01-01 00:00:00

  • Quantification of singlet oxygen from hematoporphyrin derivative by electron spin resonance.

    abstract：:The mechanism of the generation and the quantitative analysis of singlet oxygen (1O2) formed by the exposure of a hematoporphyrin derivative (HpD) to light was re-evaluated by electron spin resonance (ESR) combined with 2,2,6,6,-tetramethyl-4-piperidine (TMPD). The change from TMPD to 2,2,6,6,-tetramethyl-4-piperidine...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00835-7

    authors： Ando T,Yoshikawa T,Tanigawa T,Kohno M,Yoshida N,Kondo M

    更新日期：1997-01-01 00:00:00

  • CGS 8216, Ro 15-1788 and methyl-beta-carboline-3-carboxylate, but not EMD 41717 antagonize the muscle relaxant effect of diazepam in genetically spastic rats.

    abstract：:Diazepam (0.4-4 mg/kg i.p.) reduced the spontaneous tonic activity in the electromyogram (EMG) recorded from the gastrocnemius-soleus muscle of spastic mutant Han-Wistar rats in a dose-dependent manner. The muscle relaxant effect of diazepam was antagonized by the benzodiazepine antagonists Ro 15-1788 (5 mg/kg i.p.), ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90160-7

    authors： Schwarz M,Turski L,Sontag KH

    更新日期：1984-10-01 00:00:00

  • Benzodiazepine binding sites in rat interscapular brown adipose tissue: effect of cold environment, denervation and endocrine ablations.

    abstract：:3H-Flunitrazepam (FNZP) binding was examined in a crude membrane fraction obtained from rat interscapular brown adipose tissue (IBAT). A single population of binding sites was apparent with dissociation constant (KD) = 0.47 +/- 0.04 microM and maximal number of binding sites (Bmax) = 31 +/- 5 pmol.mg prot-1. From the ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(88)90077-x

    authors： Gonzalez Solveyra C,Romeo HE,Rosenstein RE,Estevez AG,Cardinali DP

    更新日期：1988-01-01 00:00:00

  • Evidence for the involvement of descending pain-inhibitory mechanisms in the attenuation of cancer pain by carvacrol aided through a docking study.

    abstract：AIMS:The present study evaluated the carvacrol (CARV) effect on hyperalgesia and nociception induced by sarcoma 180 (S180) in mice. MAIN METHODS:Carvacrol treatment (12.5-50mg/kgs.c.) once daily for 15days was started 24h after injection of the sarcoma cells in the hind paw (s.c.). Mice were evaluated for mechanical s...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2014.08.020

    authors： Guimarães AG,Scotti L,Scotti MT,Mendonça Júnior FJ,Melo NS,Alves RS,De Lucca Júnior W,Bezerra DP,Gelain DP,Quintans Júnior LJ

    更新日期：2014-10-22 00:00:00

  • Central interaction of dexamethasone and RU-38486 on morphine antinociception in mice.

    abstract：:The central interference induced by dexamethasone and RU-38486, (a glucocorticoid receptor antagonist) on morphine antinociception were studied by using the tail flick test in mice. Dexamethasone, injected intracerebrally (i.c.v.) 10 minutes before morphine, dose-dependently reduced morphine antinociception, whereas R...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90521-p

    authors： Capasso A,Di Giannuario A,Loizzo A,Pieretti S,Sorrentino L

    更新日期：1992-01-01 00:00:00

  • Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis.

    abstract：:Homocysteine (Hcy), an intermediate in methionine metabolism, has been proposed to be involved in hepatic fibrogenesis. Impaired liver function can alter Hcy metabolism. The aim of the present study was to determine plasma Hcy alterations in acute obstructive cholestasis and the subsequent biliary cirrhosis. Cholestas...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.12.009

    authors： Ebrahimkhani MR,Sadeghipour H,Dehghani M,Kiani S,Payabvash S,Riazi K,Honar H,Pasalar P,Mirazi N,Amanlou M,Farsam H,Dehpour AR

    更新日期：2005-04-08 00:00:00

  • Effect of methylguanidine, guanidine and structurally related compounds on constitutive and inducible nitric oxide synthase activity.

    abstract：:The inhibitory activity of methylguanidine, guanidine and their precursors, creatine and creatinine, on both the neuronal constitutive and lung inducible isoforms of nitric oxide synthase were examined in this study. Methylguanidine and guanidine (0.01-3 mM) significantly (P<0.01) inhibited in a concentration-dependen...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00673-5

    authors： Sorrentino R,Sautebin L,Pinto A

    更新日期：1997-01-01 00:00:00

  • PD-L1/PD-1 axis as a potent therapeutic target in breast cancer.

    abstract：:Although both the incidence and the mortality rate of breast cancer is rising, there is no potent and practical option for the treatment of these patients, particularly in advanced stages. One of the most critical challenges for treatment is the presence of complicated and extensive tumor escape mechanisms in the tumo...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2020.117437

    authors： Bastaki S,Irandoust M,Ahmadi A,Hojjat-Farsangi M,Ambrose P,Hallaj S,Edalati M,Ghalamfarsa G,Azizi G,Yousefi M,Chalajour H,Jadidi-Niaragh F

    更新日期：2020-04-15 00:00:00

  • Selective serotonin reuptake inhibitors (SSRI) affect murine bone lineage cells.

    abstract：AIMS:Data suggest pharmacological treatment of depression with selective serotonin reuptake inhibitors (SSRI) may impair bone health. Our group has previously modeled compromised craniofacial healing after treatment with sertraline, a commonly prescribed SSRI, and hypothesized potential culprits: alterations in bone ce...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117827

    authors： Durham E,Zhang Y,LaRue A,Bradshaw A,Cray J

    更新日期：2020-08-15 00:00:00

  • (-) deprenyl induces activities of both superoxide dismutase and catalase but not of glutathione peroxidase in the striatum of young male rats.

    abstract：:Daily s.c. injection of (-)deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused a threefold increase in superoxide dismutase (SOD) activity in the striatum of the brain compared with the value in saline-injected control rats. Furthermore, the activity of catalase (but not of glutathione peroxidase) was a...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90466-o

    authors： Carrillo MC,Kanai S,Nokubo M,Kitani K

    更新日期：1991-01-01 00:00:00

  • [11C]S21007, a putative partial agonist for 5-HT3 receptors PET studies. Rat and primate in vivo biological evaluation.

    abstract：:We recently labeled with carbon-11, a high affinity, selective, 5-HT3 receptor (5-HT3R) ligand, S21007, for potential positron emission tomography (PET) applications. To evaluate the in vivo binding properties of [11C]S21007, its brain regional distribution, tissue and plasma pharmacokinetics and plasma metabolisation...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)01058-8

    authors： Besret L,Dauphin F,Guillouet S,Dhilly M,Gourand F,Blaizot X,Young AR,Petit-Taboué MC,Mickala P,Barbelivien A,Rault S,Barré L,Baron JC

    更新日期：1998-01-01 00:00:00

  • Effects of inhalation of sevoflurane at different concentrations on TRPV1 in airways of rats at different developmental stages.

    abstract：:Aim Determine changes in the expressions of the ion channel-TRPV1-and neuropeptides-NKA, NKB, calcitonin gene-related peptide (CGRP), and SP-in 14-, 21-, and 42-day-old rats after inhaling 1.5% and 2.6% sevoflurane. MAIN METHODS:A small in-house inhalation anesthesia chamber was designed to allow 14-, 21-, and 42-day...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117472

    authors： Liu D,Yuan J,Fei X,Zhu Y,Zhou Y,Zhang C,Dong L,Zhu Z

    更新日期：2020-05-15 00:00:00

  • Characterization of a [3H]-5-hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D subtypes.

    abstract：:[3H]5-HT binding sites were analyzed in membranes prepared from the rabbit caudate nucleus (CN). [3H]5-HT labeled both 5-HT1A and 5-HT1C recognition sites, defined by nanomolar affinity for 8-OH-DPAT and mesulergine respectively; however, these represented only a fraction of total specific [3H]5-HT binding. Saturation...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90033-7

    authors： Xiong WC,Nelson DL

    更新日期：1989-01-01 00:00:00

  • Transcriptional up-regulation of nNOS in the dorsal vagal complex during low endotoxemia.

    abstract：:The present study analyses the expression and distribution of neuronal nitric oxide synthase (nNOS) in the brainstem of animals pre-treated with Escherichia coli or Helicobacter pylori LPS, at doses that modulate gastric motor function. Systemic administration of H. pylori LPS prevented in a dose-dependent manner (5, ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.03.007

    authors： Quintana E,Hernández C,Moran AP,Esplugues JV,Barrachina MD

    更新日期：2005-07-15 00:00:00

  • Assessment of herb-drug synergy to combat doxorubicin induced cardiotoxicity.

    abstract：:Aim Doxorubicin (Dox) is one of the most cardiotoxic anti-cancerous drug that is widely used for broad-range of cancers. There is an urgent need for developing cardio-oncological therapeutic interventions. Natural products having both anti-cancerous potential as well as cardioprotective effects may hold a great potent...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.05.021

    authors： Jain A,Rani V

    更新日期：2018-07-15 00:00:00

  • Effect of cucurbitacins on bilirubin-albumin binding in human plasma.

    abstract：:The aim of this study is to investigate the effect of three cucurbitacins (Cuc) E, D and I on the bilirubin-albumin binding, both in human serum albumin (HSA) and in plasma. Bilirubin-HSA solution and plasma free of cucurbitacins were prepared as well as others containing serial concentrations of cucurbitacins. The co...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2006.10.005

    authors： Greige-Gerges H,Abou Khalil R,Chahine R,Haddad C,Harb W,Ouaini N

    更新日期：2007-01-16 00:00:00

  • A comparison of the central and peripheral antimuscarinic effects of atropine and methylatropine injected systemically and into the cerebral ventricles.

    abstract：:We compared the relative abilities of atropine sulfate and methylatropine, injected i.v. and into the cerebral ventricles (icv), to block pharmacological responses mediated through central and peripheral muscarinic receptors. The hypotensive response to i.v. injection of acetylcholine (peripheral muscarinic receptors)...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(88)90389-x

    authors： Brezenoff HE,Xiao YF,Vargas H

    更新日期：1988-01-01 00:00:00

  • Elevated lipid peroxidation products and depleted transferrin levels in the plasma of kidney transplant recipients.

    abstract：:Lipid peroxidation products were measured in the plasma of 24 kidney transplant patients and 12 healthy volunteers (controls) by: (1) 2-thiobarbituric acid assay and (2) the intensity of fluorescence products of malonaldehyde cross-linked proteins. Plasma levels of creatinine, ceruloplasmin, transferrin, prealbumin, a...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90059-z

    authors： Dasgupta A,Powell D,Saldana S,Doria L

    更新日期：1990-01-01 00:00:00

  • Human melanoma-derived ectosomes are enriched with specific glycan epitopes.

    abstract：AIMS:Numerous studies confirmed the involvement of extracellular vesicles in cancer development and progression. The present study was designed to investigate the glycan composition of ectosomes derived by human cutaneous melanoma (CM) cell lines with the use of lectins. MAIN METHODS:Ectosomes released by primary (WM1...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.06.026

    authors： Surman M,Hoja-Łukowicz D,Szwed S,Drożdż A,Stępień E,Przybyło M

    更新日期：2018-08-15 00:00:00

  • Forkhead box transcription factors in embryonic heart development and congenital heart disease.

    abstract：:Embryonic heart development is a very complicated process regulated precisely by a network composed of many genes and signaling pathways in time and space. Forkhead box (Fox, FOX) proteins are a family of transcription factors characterized by the presence of an evolutionary conserved "forkhead"or "winged-helix" DNA-b...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2015.12.001

    authors： Zhu H

    更新日期：2016-01-01 00:00:00

  • Characterization and distribution of 3H-(3MeHis2)thyrotropin releasing hormone receptors in rat brain.

    abstract：:The characteristics and distribution of putative thyrotropin releasing hormone (TRH) receptors were studied in rat central nervous system using the TRH analogue 3H-(3MeHis2)TRH as a radiolabeled ligand. The analogue had a dissociation constant of 2.3 +/- 0.2 nM and a receptor density of 34 +/- 2 fm/mg protein in whole...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90315-0

    authors： Simasko SM,Horita A

    更新日期：1982-05-24 00:00:00

  • Specificity and sensitivity of S100B levels in amniotic fluid for Down syndrome diagnosis.

    abstract：:Down syndrome (DS) is the most common chromosomal abnormality and is associated with an extra copy of the chromosome 21. Although several markers are commonly used during pregnancy for the screening of DS, the definitive diagnosis is based on karyotype after amniocentesis, which is an expensive and laborious analysis....

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.09.003

    authors： Tort AB,Portela LV,da Purificação Tavares M,Gonçalves CA,Netto C,Giugliani R,Souza DO

    更新日期：2004-12-10 00:00:00

  • Effect of the anticonvulsant U-54494A on cortical neuron excitability: comparison to the kappa agonist U-50488H.

    abstract：:U-54494A, a 1,2-diamine anticonvulsant, and U-50488H, a structurally related agonist for opiate kappa receptors, were tested for effects on spontaneous and glutamate-evoked firing rates in cerebral cortex of urethane-anesthetized male Sprague-Dawley rats. Iontophoretic application of 1,2-diamines, glutamate diethyl et...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90322-g

    authors： Ochoa MC,Vogelsang GD,Lum JT,VonVoigtlander PF,Piercey MF

    更新日期：1992-01-01 00:00:00

  • Influence of anxiety on the production of oral volatile sulfur compounds.

    abstract：:Since many patients complain about halitosis without there being any clinical evidence of its cause, psychological symptoms have been pointed out as halitosis-inducing factors. The aim of this study was to evaluate the influence of anxiety on the production of volatile sulfur compounds (VSC). Seventeen undergraduate m...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2006.02.010

    authors： Calil CM,Marcondes FK

    更新日期：2006-07-10 00:00:00

  • Swim training increases ventricular atrial natriuretic factor (ANF) gene expression as an early adaptation to chronic exercise.

    abstract：:Increased ventricular ANF-mRNA is observed as a compensating mechanism in response to many forms of overload including chronic exercise. It is unknown if exercise-induced increases in ANF expression are mediated at the transcriptional level and whether specific cis-element(s) may be involved. To study this, rats were ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(02)01518-7

    authors： Edwards JG

    更新日期：2002-04-26 00:00:00

  • Protective role of AGK2 on thioacetamide-induced acute liver failure in mice.

    abstract：AIMS:The aim of the present study was to investigate the protective effects of AGK2 as a selective SIRT2 inhibitor on thioacetamide (TAA)-induced acute liver failure (ALF) in mice and its potential mechanism. MAIN METHODS:All male C57BL/6 mice were separated into control, TAA, AGK2 + TAA, and AGK2 groups. The histolog...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.05.061

    authors： Jiao FZ,Wang Y,Zhang WB,Zhang HY,Chen Q,Shi CX,Wang LW,Gong ZJ

    更新日期：2019-08-01 00:00:00

  • Use of antisense oligodeoxynucleotide to determine delta-opioid receptor involvement in [D-Ala2]deltorphin II-induced locomotor hyperactivity.

    abstract：:Intracerebroventricularly (i.c.v.)-administered [D-Ala2]deltorphin II (20 micrograms) produced a marked locomotor hyperactivity in male ICR mice. The locomotor hyperactivity induced in response to i.c.v. [D-Ala2]deltorphin II (20 micrograms) was suppressed by pretreatment with naltriben (NTB, 10 micrograms) but not 7-...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(96)00307-4

    authors： Mizoguchi H,Narita M,Nagase H,Suzuki T,Quock RM,Tseng LF

    更新日期：1996-01-01 00:00:00

  • The possible role of estrogen and selective estrogen receptor modulators in a rat model of Parkinson's disease.

    abstract：AIM:The aim of the present study was to assess and compare the effect of 17β-estradiol and two different selective estrogen receptor modulators (SERMs), tamoxifen and raloxifene, as well as a selective estrogen receptor alpha agonist, propyl-pyrazole-triol (PPT) and a selective estrogen receptor beta agonist, diarylpro...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2011.03.010

    authors： Baraka AM,Korish AA,Soliman GA,Kamal H

    更新日期：2011-05-09 00:00:00