Abstract：
:We compared the relative abilities of atropine sulfate and methylatropine, injected i.v. and into the cerebral ventricles (icv), to block pharmacological responses mediated through central and peripheral muscarinic receptors. The hypotensive response to i.v. injection of acetylcholine (peripheral muscarinic receptors) was inhibited 50% by i.v. injection of 14.3 nmol (5.5 micrograms)/kg methylatropine and 147.8n molar equivalents (50 micrograms)/kg atropine sulfate. A similar degree of inhibition followed icv injection of 49.4 nmol/kg methylatropine and 384.2 nmol equivalents/kg atropine sulfate, indicating significant leakage out of the ventricular space. The pressor response to icv injection of neostigmine (central muscarinic receptors) also was inhibited more effectively by icv methylatropine than by atropine sulfate. Methylatropine was not effective in blocking central muscarinic receptors when injected i.v.
journal_name
Life Scijournal_title
Life sciencesauthors
Brezenoff HE,Xiao YF,Vargas Hdoi
10.1016/0024-3205(88)90389-xsubject
Has Abstractpub_date
1988-01-01 00:00:00pages
905-11issue
8eissn
0024-3205issn
1879-0631pii
0024-3205(88)90389-Xjournal_volume
42pub_type
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