Abstract：
:Daily s.c. injection of (-)deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused a threefold increase in superoxide dismutase (SOD) activity in the striatum of the brain compared with the value in saline-injected control rats. Furthermore, the activity of catalase (but not of glutathione peroxidase) was also increased significantly by deprenyl treatment. The results confirmed the previous findings of Knoll on SOD activity and furthermore provided evidence that the activity of catalase is also significantly induced by the drug, which was not found in the previous study.
journal_name
Life Scijournal_title
Life sciencesauthors
Carrillo MC,Kanai S,Nokubo M,Kitani Kdoi
10.1016/0024-3205(91)90466-osubject
Has Abstractpub_date
1991-01-01 00:00:00pages
517-21issue
6eissn
0024-3205issn
1879-0631pii
0024-3205(91)90466-Ojournal_volume
48pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:We observed a significant increase in plasma atrial natriuretic factor (ANF) in antiorthostatic hypokinetic suspension (AOH) rats after 2 h of suspension when the experiment was made during day. Plasma ANF was investigated in relation to renal glomerular ANF receptors during AOH at night. The aim of this study was 1) ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(88)80008-0
更新日期：1988-01-01 00:00:00
abstract：:Estrogen can enhance or reduce lymphocyte functions in vitro depending on dose and exposure duration. The purpose of this study was to determine the effect of in vivo 17 beta-estradiol (E2) on apoptosis and necrosis in lymphoid tissue of female C567BL/6 mice. Animals were ovariectomized (OVX), ovariectomized and 17 be...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00456-2
更新日期：2000-03-03 00:00:00
abstract：AIMS:Resveratrol (Res) which is a polyphenolic phytoalexin, has various biological properties. In the present study, we investigated whether Res extracted from Polygonum cuspidatum can reduce oxidative damage and cognitive impairment in senescence-accelerated mouse (SAM). MAIN METHODS:Senescence-accelerated mice were ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.08.033
更新日期：2012-10-29 00:00:00
abstract：:The purpose of this study was to evaluate the induction of oxidative stress in heart and erythrocytes from rats with abdominal aorta coarctation (Coa) compared with sham-operated normotensive controls (Sham). The group of Coa animals developed myocardial hypertrophy, showing heart homogenates markedly increased levels...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.02.004
更新日期：2006-07-04 00:00:00
abstract：:In the early 1970's, some papers appeared reporting an immune response to opiates in animals treated with morphine and in heroin addicts, but further researches failed to confirm these results in humans. The aim of the present work is investigating with a newly developed enzyme immunoassay the existence of specific an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90656-n
更新日期：1993-01-01 00:00:00
abstract：UNLABELLED:Based on preclinical findings, cellular therapy has become a promising therapeutic approach for neonatal hypoxia-ischemia (HI). However, before translation into the clinical setting, new and effective routes of cell delivery must be determined. Intra-arterial (IA) delivery is an attractive route of cellular ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.10.017
更新日期：2014-02-06 00:00:00
abstract：:A single intravenous injection of alloxan in mice induced hyperglycemia in a dose dependent fashion. This diabetogenic action of alloxan was prevented by a single intraperitoneal injection of the alpha 2-adrenergic agonists, i.e. oxymetazoline, clonidine or epinephrine 40 min prior to the injection of alloxan. The alp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90301-6
更新日期：1983-02-14 00:00:00
abstract：:The distribution of thiamine-immunoreactive structures was studied in the brain of the monkey using an indirect immunoperoxidase technique. Fibers containing thiamine, but no thiamine-immunoreactive cell bodies, were found. The highest density of fibers containing thiamine was observed in the pulvinar nucleus and in t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.03.017
更新日期：2006-08-15 00:00:00
abstract：:Clinical studies of cholinergic pharmacotherapy, together with the putative role of the muscarinic receptor system in the neurophysiology of human behavior, support a possible muscarinic cholinergic involvement in schizophrenia. The present study has measured the density of [3H]AF-DX 384 labelled receptors (muscarinic...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00114-9
更新日期：1999-01-01 00:00:00
abstract：AIMS:Luteolin has been shown to be beneficial to cardiovascular tissues and organs. We aimed to study its vasospasmolytic effects against various vasoconstrictors in the isolated rat coronary arteries (RCAs) and its electrophysiological effects on K+ currents via voltage-gated potassium (Kv) channels and inward rectifi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.02.028
更新日期：2019-03-15 00:00:00
abstract：:The survival of osteoblast cells is one of the determinants of the development of osteoporosis in patients with inflamed synovium, such as in rheumatoid arthritis (RA). By means of alkaline phosphatase (ALP) activity and osteocalcin ELISA assay, I have shown that myricetin exhibits a significant induction of different...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.05.026
更新日期：2005-10-21 00:00:00
abstract：:Classical studies have demonstrated that the visual centers in primates consist of cortical areas V1, V2 and V4 and their branches. However, nothing is known about how these visual areas change in postnatal development. In the present studies, therefore, pigs aged 2, 4, and 6 months old, were stimulated visually with ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.06.030
更新日期：2006-02-09 00:00:00
abstract：AIMS:Parathyroid hormone-related protein (PTHrP) is a peptide growth factor produced in a wide range of tissues from brain and parathyroid, to kidney and uterus. The purpose of this study was to determine whether the adrenal cortical hormones, hydrocortisone (cortisol), modulate PTHrP expression and glucocorticoid rece...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.08.001
更新日期：2011-10-24 00:00:00
abstract：:We recently suggested that peroxisome proliferators (PP)-induced hepatocyte DNA synthesis may be mediated by a specific peroxisome proliferator activated receptor (PPAR). Heterodimers of the PPAR with the retinoid nuclear receptor, RXR, activate transcription after binding to DR1 response elements of the target genes....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00039-2
更新日期：1996-01-01 00:00:00
abstract：:Using a specific radioimmunoassay, we measured concentrations of plasma 7B2 (a novel pituitary polypeptide) immunoreactivity (7B2-IR) in normal human subjects, patients with chronic renal failure and those with liver cirrhosis. Mean (+/- SEM) values of plasma 7B2-IR in normal healthy men and women were 55.8 +/- 1.2 pg...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90685-0
更新日期：1987-08-24 00:00:00
abstract：:Mucosal mast cells are implicated in visceral hypersensitivity associated with irritable bowel syndrome (IBS). In this study, we investigated the role of mast cells in the development of visceral hypersensitivity by using mast cell deficient (Ws/Ws) rats and their control (W+/W+). In W+/W+ rats, an injection of 2,4,6-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.11.027
更新日期：2008-02-13 00:00:00
abstract：:Lymphocyte apoptosis occurs in response to stressors such as thermal injury, trauma, sepsis, and surgery. This study evaluated the effect of a single bout of physical exercise stress on the induction of apoptosis in murine thymocytes and splenic lymphocytes. Female C57BL/6 mice, treadmill exercised at a submaximal int...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00551-7
更新日期：1999-01-01 00:00:00
abstract：:The intracellular ionic content of human erythrocytes may be altered by hyperglycaemia. Despite this, very little is known about the cellular mechanisms linking glucose and cellular magnesium homeostasis. We measured intracellular ionized magnesium in human lymphocytes, by means of a fluorimetric technique, total intr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01992-6
更新日期：2002-09-20 00:00:00
abstract：:Neuropeptide Y (NPY) was found in high concentrations in the male genital tract. NPY levels were highest in the seminal vesicles, prostate, corpus cavernosum and vas deferens, where large numbers of immunoreactive nerve fibres were detected. Considerable quantities were also found in the epididymis and spongiosum. Low...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90033-x
更新日期：1984-12-24 00:00:00
abstract：:Effects of hexamethonium (C6) on the excitability of sympathetic ganglion cells were examined by means of intracellular recording. When DC currents were injected, high concentrations of C6 significantly augmented the repetitive firing of the cells without any change in threshold voltage for initiation of the spike. Th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90324-8
更新日期：1985-06-17 00:00:00
abstract：:Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2004.05.034
更新日期：2004-11-05 00:00:00
abstract：:Oxidative stress has been implicated to play an important role in the pathogenesis of diabetic neuropathy, which is the most common complication of diabetes mellitus affecting more than 50% of diabetic patients. In the present study, we have investigated the effect of U83836E [(-)-2-((4-(2,6-Di-1-pyrrolidinyl-4-pyrimi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.02.033
更新日期：2006-07-17 00:00:00
abstract：AIMS:Hypoxia makes cells death but it is not always true. Short term anoxia can boost remaining cells activities and promote tissue repair. This study is to explore the effects of hypoxic preconditioning (HP) on osteoblasts and analyze the involved lncRNA and mRNA. MAIN METHODS:Human osteoblast was used. Normoxic cont...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.07.014
更新日期：2018-09-01 00:00:00
abstract：:We studied the effects of caffeine on intracellular calcium in a clonal insulin-secreting cell line RINm5F. Caffeine (1-30 mM) induced a dose-dependent intracellular Ca2+ release and Ca2+ influx. Pretreatment with combination of ryanodine (10 microM) and caffeine (10 mM), but not ryanodine alone, abolished subsequent ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00046-x
更新日期：1996-01-01 00:00:00
abstract：:Twice daily injection of caffeine (30 mg/kg) for 3-1/2 days shifted the caffeine stimulus generalization curve to the right by 3-fold in rats trained to discriminate saline from 30 mg/kg of caffeine, and by 4-fold in rats trained to discriminate saline from 10 mg/kg of caffeine. The latter group was also tested for cr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90140-8
更新日期：1987-01-26 00:00:00
abstract：:Species-related specific differences in the pharmacological profile of vasopressin V1a receptors have been reported. Thus, the aim of the present study was to identify a vascular preparation of human origin expressing V1a receptors. Vasopressin was found to contract human gastric artery strips without endothelium with...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00635-2
更新日期：1997-01-01 00:00:00
abstract：:The aims of this study were to determine whether endothelin-1 (ET-1), a positive inotropic agent, altered the production of cyclic AMP (cAMP) in adult feline cardiac myocytes and to characterize the effect with respect to G-protein-coupling and calcium regulation of adenylyl cyclase. ET-1 inhibited basal and/or stimul...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02264-3
更新日期：1996-01-01 00:00:00
abstract：:Involvement of cyclic AMP-dependent protein kinase in the desensitization of GABAB receptor expressed in Xenopus oocytes was studied. GABA produced an outward current in the presence of bicuculline, under voltage-clamp conditions. Baclofen mimicked the effect of GABA, thereby indicating that the response to GABA in th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02235-1
更新日期：1995-11-17 00:00:00
abstract：:We measured the concentration of immunoreactive (IR) hEGF in various body fluids by radioimmunoassay (RIA) and evaluated its size heterogeneity by size exclusion high performance liquid chromatography combined with RIA or with time-resolved immunofluorometric assay (TR-IFMA). Mean concentration was 80 ng/ml in urine, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90069-5
更新日期：1987-06-29 00:00:00
abstract：AIMS:Evidence suggests that hypobaric hypoxia (HH) exposure causes biochemical and molecular level perturbations in brain resulting in associated cognitive dysfunction. However, the possible effect of HH on amygdala and the associated limbic regions based functions remains elusive. Regulated fear expression is essentia...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117555
更新日期：2020-08-01 00:00:00
