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Protection against alloxan-induced diabetes in mice by stimulation of alpha 2-adrenergic receptors.

Abstract：

:A single intravenous injection of alloxan in mice induced hyperglycemia in a dose dependent fashion. This diabetogenic action of alloxan was prevented by a single intraperitoneal injection of the alpha 2-adrenergic agonists, i.e. oxymetazoline, clonidine or epinephrine 40 min prior to the injection of alloxan. The alpha 1-adrenergic agonists, i.e. methoxamine and phenylephrine, and a beta-adrenergic agonist, isoproterenol, failed to prevent the diabetogenic action of alloxan. The inhibitory effect of clonidine on alloxan-induced diabetes was antagonized by yohimbine or phentolamine, but not by prazosin. Although alpha 2-adrenergic agonists caused a transient hyperglycemia at the time of alloxan administration (40 min after the administration of alpha 2-adrenergic agonists), the plasma glucose level at the time of alloxan injection did not correlate with the anti-diabetogenic effect of alpha 2-adrenergic agents. These results clearly demonstrate that the alpha 2-adrenergic mechanism which inhibits insulin release from pancreatic B cells prevented the diabetogenic action of alloxan in mice.

journal_name

Life Sci

journal_title

Life sciences

authors

Nakadate T,Nakaki T,Yamamoto S,Kato R

doi

10.1016/0024-3205(83)90301-6

subject

Has Abstract

pub_date

1983-02-14 00:00:00

pages

697-702

issue

7

eissn

0024-3205

issn

1879-0631

pii

0024-3205(83)90301-6

journal_volume

32

pub_type

杂志文章

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