Functional characteristics of cysteinyl-leukotriene receptor subtypes.

Abstract:

:Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors, CysLT1 and CysLT2, have been cloned and functionally characterised using potent CysLT1 receptor antagonists and the dual CysLT1/CysLT2 receptor antagonist BAY u9773. However, the rank order of potency of the cysteinyl-leukotrienes at the CysLT receptors differs between tissues and studies, and a CysLT receptor classification based on agonist selectivity has not been established. In addition, the existence of more than two receptor subtypes for cysteinyl-leukotrienes has been suggested.

journal_name

Life Sci

journal_title

Life sciences

authors

Bäck M

doi

10.1016/s0024-3205(02)01733-2

subject

Has Abstract

pub_date

2002-06-28 00:00:00

pages

611-22

issue

6

eissn

0024-3205

issn

1879-0631

pii

S0024320502017332

journal_volume

71

pub_type

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