Abstract：
:The effect of the Type I benzodiazepine (BDZ) receptor agonist, CL 218,872, on convulsions generated by low doses of methyl beta-carboline-3-carboxylic acid ( MBCC ), bicuculline, picrotoxin and pentylenetetrazole (PTZ) in mice was examined. Low doses of CL 218,872 enhanced the convulsions produced by all agents except PTZ. An anticonvulsant action of CL 218,872 was observed at higher doses. Since CL 218,872 exhibits proconvulsive effects at low doses, and a proconvulsant action is a characteristic of compounds classified as BDZ antagonists, it appears that CL 218,872 has some antagonist action.
journal_name
Life Scijournal_title
Life sciencesauthors
Melchior CL,Garrett KM,Tabakoff Bdoi
10.1016/0024-3205(84)90321-7subject
Has Abstractpub_date
1984-05-28 00:00:00pages
2201-6issue
22eissn
0024-3205issn
1879-0631pii
0024-3205(84)90321-7journal_volume
34pub_type
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