Abstract：
:Adrenals of young adult male mice kept on a LD 12:12 lighting regimen for three weeks prior to study and harvested at four different circadian stages were incubated for 2 hours with 0.4 IU synthetic ACTH in 2 ml Krebs-Ringer buffer (KR), or with 50, 150, and 450 microM of melatonin in KR containing 0.4 IU ACTH. The addition of melatonin to ACTH leads to a dose dependent stimulation of production and/or secretion of DHEA into the incubation medium irrespective of the circadian stage of harvesting of the adrenals. This relationship is of interest in view of the simultaneous decrease of dehydroepiandrosterone and melatonin in the course of aging, and the effects of these compounds upon aging related changes.
journal_name
Life Scijournal_title
Life sciencesauthors
Haus E,Nicolau GY,Ghinea E,Dumitriu L,Petrescu E,Sackett-Lundeen Ldoi
10.1016/0024-3205(96)00079-3subject
Has Abstractpub_date
1996-01-01 00:00:00pages
PL263-7issue
14eissn
0024-3205issn
1879-0631pii
0024320596000793journal_volume
58pub_type
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