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Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects.

Abstract：

:In order to investigate possible neurobiologic mechanisms underlying carbon dioxide-induced anxiety, the effects of oral alprazolam 0.75 mg and intravenous clonidine 2 mcg/kg on CO2-induced increases in ratings of subjective anxiety, pulse rate, and ventilation were measured in healthy human subjects. Pretreatment with alprazolam but not with clonidine significantly reduced the CO2-induced increase in ratings of anxiety. Neither drug altered CO2-induced increases in pulse rate or ventilatory responses. Clonidine did produce potent sedative and hypotensive effects. The behavioral data suggest that the mechanisms through which CO2 induces anxiety-like effects involve neural systems regulated by benzodiazepine receptors and, secondly, that they appear not to require normal functioning of noradrenergic systems. Carbon dioxide may provide a useful model system for identification of new drugs with anxiolytic properties.

journal_name

Life Sci

journal_title

Life sciences

authors

Woods SW,Krystal JH,Heninger GR,Charney DS

doi

10.1016/0024-3205(89)90255-5

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

233-42

issue

3

eissn

0024-3205

issn

1879-0631

pii

0024-3205(89)90255-5

journal_volume

45

pub_type

杂志文章

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