Abstract：
:Previously we have reported a decreased GABAB receptor expression in brain of spontaneously hepertensive rats (SHR). Moreover, decreased receptor numbers were accompanied by depressed stimulation of cAMP formation. We have now quantified Gi alpha protein by immunoblotting in cerebral membranes from 11-week-old normotensive Wistar-Kyoto rats (WKY) and hepertensive SHR. The levels of the alpha-subunit in the two sets of membranes were similar. In conclusion, the reduced response in adenylate cyclase activity to agents that function via the Gi protein, e.g., GABAB receptor agonists, in SHR brain is not a consequence of altered level of Gi alpha protein.
journal_name
Life Scijournal_title
Life sciencesauthors
Ichida T,Takeda K,Sasaki S,Nakagawa M,Kuriyama Kdoi
10.1016/s0024-3205(96)00573-5subject
Has Abstractpub_date
1996-01-01 00:00:00pages
2167-71issue
25-26eissn
0024-3205issn
1879-0631pii
S0024-3205(96)00573-5journal_volume
59pub_type
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