当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > CB2-deficiency is associated with a stronger hypertrophy and remodeling of the right ventricle in a murine model of left pulmonary artery occlusion.

CB2-deficiency is associated with a stronger hypertrophy and remodeling of the right ventricle in a murine model of left pulmonary artery occlusion.

Abstract：

AIMS:Pulmonary hypertension (PH) leads to right ventricular (RV) adaptation and remodeling and has deleterious long-term effects on RV function. The endocannabinoid receptor CB2 has been associated with protective effects in adaptation and remodeling of the left ventricle after ischemia. Therefore, we investigated the role of CB2 receptor in RV adaptation after occlusion of the left pulmonary artery (LPA) in a murine model. MAIN METHODS:C57/Bl6 (WT)- and CB2 receptor-deficient (Cnr2-/-)-mice underwent paramedian sternotomy and LPA was occluded using a metal clip. Right heart hemodynamic study (Millar®) preceded organ harvesting for immunohistochemistry and mRNA analysis 7 and 21 days (d) post-occlusion. KEY FINDINGS:LPA occlusion led to higher RV systolic pressure in Cnr2-/--hearts, while hemodynamics were comparable with WT-hearts after 21d. Cnr2-/--hearts showed higher macrophage infiltration and lower interleukin-10 expression after 7 d, but otherwise a comparable inflammatory mediator expression profile. Cardiomyocyte-hypertrophy was stronger in Cnr2-/--mice, presenting with higher tenascin-C expression than WT-hearts. Planimetry revealed higher collagen area in Cnr2-/--hearts and small areas of cardiomyocyte-loss. Surrounding cardiomyocytes were cleaved caspase-3- and TUNEL positive in Cnr2-/--hearts. This was associated by maladaptation of myosin heavy-chain isoforms and lower reactive oxygen scavenger enzymes induction in Cnr2-/--hearts. We found comparable morphological changes in both lungs between the two genotypes. SIGNIFICANCE:LPA occlusion led to increased systolic pressure and adaptation of RV in CB2-deficient mice. CB2 receptor seems to modulate RV adaptation through expression of contractile elements, reactive oxygen scavenger enzymes, and inflammatory response in order to prevent cardiomyocyte apoptosis.

journal_name

Life Sci

journal_title

Life sciences

authors

Duerr GD,Feißt A,Halbach K,Verfuerth L,Gestrich C,Wenzel D,Zimmer A,Breuer J,Dewald O

doi

10.1016/j.lfs.2018.11.003

subject

Has Abstract

pub_date

2018-12-15 00:00:00

pages

96-105

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(18)30708-2

journal_volume

215

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Correlation between (3H)dopamine specific uptake and (3H)GBR 12783 specific binding during the maturation of rat striatum.

    abstract：:The development of the specific uptake of dopamine in the rat striatum during the early postnatal period is compared with the ontogenetic changes of the specific binding of (3H)GBR 12783 to the site of uptake inhibition. During maturation, the increase in the specific binding of (3H)GBR 12783 parallels the increase in...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90563-8

    authors： Bonnet JJ,Costentin J

    更新日期：1989-01-01 00:00:00

  • Regional brain metabolic activation during craving elicited by recall of previous drug experiences.

    abstract：:Cocaine cues elicit craving and physiological responses. The cerebral circuits involved in these are poorly understood. The purpose of this study was to assess the relation between regional brain activation and cocaine cue elicited responses. Thirteen right-handed cocaine abusers were scanned with positron emission to...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00619-5

    authors： Wang GJ,Volkow ND,Fowler JS,Cervany P,Hitzemann RJ,Pappas NR,Wong CT,Felder C

    更新日期：1999-01-01 00:00:00

  • Clinical value of plasma pentraxin 3 levels for predicting cardiac troponin elevation after percutaneous coronary intervention.

    abstract：AIMS:Post-procedural myocardial necrosis manifested by elevated cardiac troponin T (cTnT) often complicates percutaneous coronary intervention (PCI). Plasma pentraxin 3 (PTX3) levels are increased in patients with arterial inflammation and especially unstable angina pectoris (UAP). This study tested whether plasma PTX3...

    journal_title：Life sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.lfs.2013.11.021

    authors： Wang Z,Sato A,Akiyama D,Kimura T,Tajiri K,Hoshi T,Sakai S,Koike A,Miyauchi T,Aonuma K

    更新日期：2014-01-24 00:00:00

  • Magnesium ion: a possible physiological regulator of aldosterone production.

    abstract：:We examined the direct effect of magnesium ion on aldosterone production by adrenal cells using collagenase-dispersed zona-glomerulosa cells in rats. The effects of magnesium on aldosterone production stimulated by angiotensin II or ACTH were also investigated. Both magnesium sulphate (MgSO4) and magnesium chloride (M...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90327-5

    authors： Atarashi K,Matsuoka H,Takagi M,Sugimoto T

    更新日期：1989-01-01 00:00:00

  • The involvement of central cholinergic mechanisms in cardiovascular responses to intracerebroventricular and intravenous administration of thyrotropin-releasing hormone.

    abstract：:Intracerebroventricular (i.c.v.) administration of thyrotropin-releasing hormone (TRH) in a range from 0.1 to 100 micrograms induced a dose-related increase in blood pressure in conscious rats, whereas TRH-free acid (TRH-OH) and histidyl-proline diketopiperazine (His-Pro-DKP), metabolites of TRH, did not. The blood pr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90586-8

    authors： Okuda C,Mizobe T,Miyazaki M

    更新日期：1987-03-30 00:00:00

  • Strain specific differences in memory and neuropathology in a mouse model of Alzheimer's disease.

    abstract：AIMS:Studies using transgenic mouse strains that incorporate Alzheimer's disease (AD) mutations are valuable for the identification of signaling pathways, potential drug targets, and possible mechanisms of disease that will aid in our understanding of AD. However, reports on the effects of specific AD mutations (Swedis...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2010.04.014

    authors： Glazner KA,Odero GL,Anema E,Motnenko A,Schapansky J,Grossman D,Oliver DR,Glazner GW,Albensi BC

    更新日期：2010-06-19 00:00:00

  • Possible involvement of activation of P53/P21 and demethylation of RUNX 3 in the cytotoxicity against Lovo cells induced by 5-Aza-2'-deoxycytidine.

    abstract：AIMS:In our model, we aimed to explore the cytotoxicity of 5-Aza-2'-deoxycytidine (5-Aza-CdR) against the colorectal cell line, Lovo, and further characterize the possible mechanisms. MAIN METHODS:After Lovo cells were treated with 5-Aza-CdR at different concentrations for different periods of time, the cell viability...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2008.12.015

    authors： Deng T,Zhang Y

    更新日期：2009-02-27 00:00:00

  • Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats.

    abstract：:Increased oxidative stress and antioxidant deficit have been suggested to play a major role in adriamycin induced cardiomyopathy and congestive heart failure due to multiple treatments with adriamycin. In this study the cardio protective effect of Centella asiatica on myocardial marker enzymes and antioxidant enzymes ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.09.009

    authors： Gnanapragasam A,Ebenezar KK,Sathish V,Govindaraju P,Devaki T

    更新日期：2004-12-17 00:00:00

  • Constitutively active muscarinic receptors.

    abstract：:Mutations that increase constitutive activity and alter ligand binding have been used to investigate the structure and mechanism of activation of muscarinic receptors. These data are reviewed with reference to the recently published three-dimensional structure of rhodopsin. Residues in TM3 and TM6 where amino acid sub...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0024-3205(01)01046-3

    authors： Spalding TA,Burstein ES

    更新日期：2001-04-27 00:00:00

  • Hyperpolarization contributes to vascular hyporeactivity in rats with lipopolysaccharide-induced endotoxic shock.

    abstract：:We have examined the role of membrane hyperpolarization in mediating vascular hyporeactivity induced by bacterial lipopolysaccharide (LPS) in endothelial-denuded strips of rat thoracic aorta ex vivo. The injection of rats with LPS caused a significant fall of blood pressure and a severe vascular hyporeactivity to nore...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)00978-4

    authors： Chen SJ,Wu CC,Yang SN,Lin CI,Yen MH

    更新日期：2000-12-29 00:00:00

  • Reduction of stress-induced analgesia following ethanol exposure in mice.

    abstract：:In the present study, we examined the effects of ethanol treatment on the subsequent expression of opioid and nonopioid forms of swim stress-induced analgesia (SSIA). In Experiment 1, mice were injected with ethanol (2.5 g/kg, i.p.) or an equal volume of saline once a day for two days. Animals received no treatment on...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00328-2

    authors： Bell RL,Soignier RD,Olson RD,Vaccarino AL

    更新日期：1998-01-01 00:00:00

  • Cyclosporine augments reactivity of isolated blood vessels.

    abstract：:Administration of cyclosporine (CS) as an immunosuppressive agent in clinical transplantation is associated with multiple side effects including nephrotoxicity and hypertension. These two effects could be related in that the renal changes may be secondary to alterations in organ blood flow. The present studies investi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90080-4

    authors： Lamb FS,Webb RC

    更新日期：1987-06-29 00:00:00

  • Histogranin, a modified histone H4 fragment endowed with N-methyl-D-aspartate antagonist and immunostimulatory activities.

    abstract：:Histogranin is a naturally-occurring pentadecapeptide with a structure 80% homologous with that a fragment-(86-100) of histone H4. First isolated from bovine adrenal medulla, the peptide was also shown to be present in the pituitary, brain, adrenal glands, blood plasma, lungs and spleen. At the subcellular level, hist...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/0024-3205(95)00068-2

    authors： Lemaire S,Rogers C,Dumont M,Shukla VK,Lapierre C,Prasad J,Lemaire I

    更新日期：1995-03-03 00:00:00

  • Pressor and cardioaccelerator effects of gamma MSH and related peptides.

    abstract：:We have recently demonstrated that the hypertensinogenic and natriuretic actions of ACTHI-39 can be found in a non-steroidogenic fragment of ACTH, ACTH4-10. These effects of ACTH or ACTH4-10 may be due to their ability to act as weak agonists of gamma MSH. gamma MSH is found in the 16K N-terminus of pro-opiocortin, an...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90197-3

    authors： Klein MC,Hutchins PM,Lymangrover JR,Gruber KA

    更新日期：1985-02-25 00:00:00

  • Influence of an alternative reinforcer on human cocaine self-administration.

    abstract：:Identifying factors that modulate cocaine self-administration is fundamental to the development of effective strategies to treat and prevent cocaine abuse. In the present study, the influence of an alternative reinforcer on the probability of cocaine use was examined in four adult humans under controlled laboratory co...

    journal_title：Life sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/0024-3205(94)00878-7

    authors： Higgins ST,Bickel WK,Hughes JR

    更新日期：1994-01-01 00:00:00

  • Effect of a novel benzamide, YM-09151-2, on rat serum prolactin levels.

    abstract：:YM-09151-2(cis-N-(1-benzyl-2-methylpyrrolidin-3-yl) -5-chloro-2-methoxy-4-methylaminobenzamide) is a new benzamide which has been reported to be an antagonist of dopamine (DA) at D1-type DA receptors. In the present study, we have examined the extent of the interaction of YM-09151-2 with D2-type DA receptors in the an...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90933-5

    authors： Meltzer HY,Mikuni M,Simonovic M,Gudelsky GA

    更新日期：1983-02-28 00:00:00

  • Streptozotocin-induced diabetes increases fructose 2,6-biphosphate levels and glucose metabolism in thymus lymphocytes.

    abstract：:Acute effect of streptozotocin-induced diabetes on several parameters of glucose metabolism was investigated in thymus lymphocytes (thymocytes). The cells from diabetics rats accumulated in vitro about 2-fold more fructose 2,6-bisphosphate (Fru-2, 6-P2) in the presence of increasing glucose concentration than cells fr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)02312-7

    authors： Moreno-Aurioles VR,Montaño R,Conde M,Bustos R,Sobrino F

    更新日期：1996-01-01 00:00:00

  • Methyl-substitution of benzene and toluene in preparations of human bone marrow.

    abstract：:The metabolism of benzene and toluene was investigated in preparations of human bone marrow incubated with S-adenosyl-L-methionine. Benzene undergoes a methyl-substitution reaction to yield toluene as a metabolite. Furthermore, toluene undergoes methyl-substitution in preparations of human bone marrow incubated with S...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90100-p

    authors： Flesher JW,Myers SR

    更新日期：1991-01-01 00:00:00

  • Activation of estrogen receptor α (ERα) is required for Alisol B23-acetate to prevent post-menopausal atherosclerosis and reduced lipid accumulation.

    abstract：:The risk of atherosclerosis (AS) ascends among post-menopausal women, while current hormone replacement therapy exerts several adverse effects. Alisol B 23-acetate (AB23A), a tetracyclic triterpenoid isolated from the rhizome of Alisma orientale, was reported to show multiple physiological activities, including regula...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118030

    authors： Chen Q,Chao Y,Zhang W,Zhang Y,Bi Y,Fu Y,Cai D,Meng Q,Li Y,Bian H

    更新日期：2020-10-01 00:00:00

  • Elevations in C-reactive protein and endothelin-1 system activity in humans.

    abstract：AIMS:C-reactive protein (CRP) is an inflammatory cytokine that has been shown to be an independent predictor of future atherothrombotic events. Hyperactivity of endothelin-1 (ET-1), a potent vasoconstrictor peptide produced by the endothelium, is linked with cardiovascular disease development and progression. ET-1 is s...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2015.12.030

    authors： Dow CA,Templeton DL,Lincenberg GM,Greiner JJ,Stauffer BL,DeSouza CA

    更新日期：2016-08-15 00:00:00

  • Endogenous expression of nNOS protein in several neuronal cell lines.

    abstract：:Several neuronal cell lines were screened for endogenous expression of neuronal nitric oxide synthase (nNOS) protein using Western blot analysis. Detectable levels of the nNOS protein were evident in the SK-N-SH, SH-SY5Y, and N1E-115 neuroblastoma cell lines, as well as the NG108-15 neuroblastoma x glioma hybrid. Only...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(02)01732-0

    authors： Grant MK,Cuadra AE,El-Fakahany EE

    更新日期：2002-07-05 00:00:00

  • Excretion of urinary epidermal growth factor in non-insulin dependent diabetes mellitus.

    abstract：:Morning urine samples were assayed for human EGF (hEGF) in 137 non-insulin dependent diabetic patients with normal serum creatinine and beta 2-microglobulin levels. Serving as controls, 80 age- and sex-matched healthy subjects were also examined. A significant positive correlation between hEGF excretion and the level ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90100-h

    authors： Kawaguchi M,Kamiya Y,Ito J,Fujii T,Hayakawa F,Sakuma N,Fujinami T

    更新日期：1993-01-01 00:00:00

  • Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages.

    abstract：:Lipopolysaccharide (LPS) has been known to induce endotoxin shock via production of inflammatory modulators such as tumor necrosis factor alpha (TNF-alpha), or nitric oxide (NO). In this study, we have examined the effect of naringin (NG), one of the flavonoids, on LPS-induced endotoxin shock in mice and NO production...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.04.051

    authors： Kanno S,Shouji A,Tomizawa A,Hiura T,Osanai Y,Ujibe M,Obara Y,Nakahata N,Ishikawa M

    更新日期：2006-01-11 00:00:00

  • ATP enhances catecholamine uptake into PC12 cells.

    abstract：:Catecholamine uptake into PC12 cells, in the presence and absence of ATP, was measured in a bicarbonate-buffered Krebs Ringer. ATP enhanced significantly the uptake in a dose-dependent manner with maximal uptake at 1-3 mM. ATP increased the Vmax of uptake by 3-5 fold for both dopamine and norepinephrine, without a sig...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)00128-s

    authors： Eshleman A,Dunigan C,Shamoo A,Eldefrawi M

    更新日期：1995-01-01 00:00:00

  • cDNA microarray analysis of the differentially expressed genes involved in murine pre-osteoclast RAW264.7 cells proliferation stimulated by dexamethasone.

    abstract：:Glucocorticoids (GCs) are hormones with anti-inflammatory and immuno-suppressive effects. The use of hormonal medicine like GCs may cause systemic adverse effects. In the present study, the cellular response of murine pre-osteoclast cell line RAW264.7 to dexamethasone (DEX) was investigated and the result demonstrated...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.10.012

    authors： Zhang Q,Fong CC,Zhang Y,Tzang CH,Fong WF,Yang M

    更新日期：2008-01-16 00:00:00

  • Abolishment of TNBS-induced visceral hypersensitivity in mast cell deficient rats.

    abstract：:Mucosal mast cells are implicated in visceral hypersensitivity associated with irritable bowel syndrome (IBS). In this study, we investigated the role of mast cells in the development of visceral hypersensitivity by using mast cell deficient (Ws/Ws) rats and their control (W+/W+). In W+/W+ rats, an injection of 2,4,6-...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.11.027

    authors： Ohashi K,Sato Y,Kawai M,Kurebayashi Y

    更新日期：2008-02-13 00:00:00

  • Analytical surveillance of emerging drugs of abuse and drug formulations.

    abstract：:Uncontrolled recreational drugs are proliferating in number and variety. Effects of long-term use are unknown, and regulation is problematic, as efforts to control one chemical often lead to several other structural analogs. Advanced analytical instrumentation and methods are continuing to be developed to identify dru...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2012.10.031

    authors： Thomas BF,Pollard GT,Grabenauer M

    更新日期：2013-03-19 00:00:00

  • Phospholipid hydroperoxides are significantly less toxic to cultured endothelial cells than fatty acid hydroperoxides.

    abstract：:Optically active hydroperoxides of phospholipids including phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, and phosphatidic acid were synthesized, and their cytotoxicity to cultured bovine pulmonary artery endothelial cells was examined. Phospholipid hydroperoxides were readily incorporated into c...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)00684-9

    authors： Kaneko T,Baba N,Matsuo M

    更新日期：1994-01-01 00:00:00

  • Phospholipase A2 inhibits nuclear nucleoside triphosphatase activity and mRNA export in isolated nuclei from rat liver.

    abstract：:The present study is undertaken to investigate whether the phospholipase A(2) (PLA(2)) influences mRNA nucleocytoplasmic transport evaluated by nucleoside triphosphatase (NTPase) activity and mRNA export in isolated hepatic nuclear envelope. Isolated hepatic nuclei from rat liver were exposed to PLA(2) (10(-5) approxi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(03)00357-6

    authors： Li JX,Li ZQ,Pang YZ,Tang CS

    更新日期：2003-07-11 00:00:00

  • Chronic intermittent hypobaric hypoxia protects vascular endothelium by ameliorating autophagy in metabolic syndrome rats.

    abstract：AIMS:The study aimed to investigate the protective effect of chronic intermittent hypobaric hypoxia (CIHH) on endothelium function and relaxation of mesenteric artery in metabolism syndrome (MS) rats. MAIN METHODS:Male adult Sprague-Dawley rats were randomly divided into control (CON), CIHH (treated with 28-days hypob...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.05.008

    authors： Cui F,Guan Y,Guo J,Tian YM,Hu HF,Zhang XJ,Zhang Y

    更新日期：2018-07-15 00:00:00