Abstract：
:Optically active hydroperoxides of phospholipids including phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, and phosphatidic acid were synthesized, and their cytotoxicity to cultured bovine pulmonary artery endothelial cells was examined. Phospholipid hydroperoxides were readily incorporated into cells during the incubation in a medium containing each hydroperoxide. Phospholipids with a linoleic acid hydroperoxide residue showed no toxicity, whereas phosphatidylcholine with an arachidonic acid hydroperoxide residue was somewhat toxic. When hydroperoxyarachidonoylphosphatidylcholine was reduced to hydroxyarachidonoylphosphatidylcholine, the reduction product was found to have no toxicity. It appears that phospholipid hydroperoxides, unless converted into more reactive compounds, are significantly less toxic to endothelial cells than fatty acid hydroperoxides.
journal_name
Life Scijournal_title
Life sciencesauthors
Kaneko T,Baba N,Matsuo Mdoi
10.1016/0024-3205(94)00684-9subject
Has Abstractpub_date
1994-01-01 00:00:00pages
1443-9issue
19eissn
0024-3205issn
1879-0631pii
0024-3205(94)00684-9journal_volume
55pub_type
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