Thermal inactivation of SARS COVID-2 virus: Are steam inhalations a potential treatment?

Abstract:

BACKGROUND:The emergence of SARS-CoV-2 pandemic has upset health systems around the world and caused immeasurable losses and costs. Until a vaccine will become available, the recommended prevention measures remain physical distancing and enhanced hygiene. METHODS AND FINDINGS:The proteic structure external to the virus is the main target that may eventually lead to reduce or block its replication in the upper airways. We developed a protocol based of repeated steam inhalation cycles aimed at reducing the risk of progression to full blown infection if performed soon after contagion. The protocol has been used in a single-center open label trial on ten infected asymptomatic or pauci-symptomatic health care professionals. CONCLUSIONS:The promising results we obtained with this easily accessible, non-invasive and inexpensive procedure should prompt controlled trials.

journal_name

Life Sci

journal_title

Life sciences

authors

la Marca G,Barp J,Frenos S,Mugelli A,Galli L,Calistri E,Biasucci G,De Masi S,Guerrini R

doi

10.1016/j.lfs.2020.118801

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

118801

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(20)31554-X

journal_volume

265

pub_type

杂志文章
  • The adipokine chemerin augments vascular reactivity to contractile stimuli via activation of the MEK-ERK1/2 pathway.

    abstract:AIMS:Cytokines interfere with signaling pathways and mediators of vascular contraction. Endothelin-1 (ET-1) plays a major role on vascular dysfunction in conditions characterized by increased circulating levels of adipokines. In the present study we tested the hypothesis that the adipokine chemerin increases vascular c...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2012.04.013

    authors: Lobato NS,Neves KB,Filgueira FP,Fortes ZB,Carvalho MH,Webb RC,Oliveira AM,Tostes RC

    更新日期:2012-10-15 00:00:00

  • Pharmacological characterization of a vasopressin V1 receptor in the isolated human gastric artery.

    abstract::Species-related specific differences in the pharmacological profile of vasopressin V1a receptors have been reported. Thus, the aim of the present study was to identify a vascular preparation of human origin expressing V1a receptors. Vasopressin was found to contract human gastric artery strips without endothelium with...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(96)00635-2

    authors: Calò G,Rizzi A,Traina L,Regoli D

    更新日期:1997-01-01 00:00:00

  • Strain specific differences in memory and neuropathology in a mouse model of Alzheimer's disease.

    abstract:AIMS:Studies using transgenic mouse strains that incorporate Alzheimer's disease (AD) mutations are valuable for the identification of signaling pathways, potential drug targets, and possible mechanisms of disease that will aid in our understanding of AD. However, reports on the effects of specific AD mutations (Swedis...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2010.04.014

    authors: Glazner KA,Odero GL,Anema E,Motnenko A,Schapansky J,Grossman D,Oliver DR,Glazner GW,Albensi BC

    更新日期:2010-06-19 00:00:00

  • Oxidation of carbon tetrachloride, bromotrichloromethane, and carbon tetrabromide by rat liver microsomes to electrophilic halogens.

    abstract::In order to determine whether CCl4, CBrCl3, CBr4 or CHCl3 undergo oxidative metabolism to electrophilic halogens by liver microsomes, they were incubated with liver microsomes from phenobarbital pretreated rats in the presence of NADPH and 2,6-dimethylphenol. The analysis of the reaction mixtures by capillary gas chro...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(82)90644-0

    authors: Mico BA,Branchflower RV,Pohl LR,Pudzianowski AT,Loew GH

    更新日期:1982-01-11 00:00:00

  • Neuropeptides in human cerebrospinal fluid.

    abstract::Ten neuropeptides were measured by RIA in human cerebrospinal fluid obtained from 30 normal volunteers. The levels of seven peptides (corticotropin releasing factor, adrenocorticotropin, vasoactive intestinal peptide, somatostatin, beta-endorphin, beta-lipotropin, and the N-terminal fragment of proopiomelanocortin) we...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(85)90139-0

    authors: Berrettini WH,Nurnberger JI Jr,Gold PW,Chretien M,Chrousos GP,Chan JS,Goldin LR,Gershon ES

    更新日期:1985-09-30 00:00:00

  • Morphine reduces pulmonary inflammation in response to influenza infection.

    abstract::The present study shows that morphine reduces the pulmonary inflammatory response to intranasal influenza virus infection in rats. Rats were infected with rat-adapted influenza virus (RAIV), which is a unique infectious agent because normal rats develop an acute pulmonary inflammatory response to RAIV and rapidly clea...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(99)00348-3

    authors: Coussons-Read ME,Daniels M,Gilmour MI

    更新日期:1999-01-01 00:00:00

  • Radioprotective efficacy of delta-tocotrienol, a vitamin E isoform, is mediated through granulocyte colony-stimulating factor.

    abstract:AIMS:The objectives of this study were to determine the cytokine induction by delta tocotrienol (DT3, a promising radiation countermeasure) and to investigate the role of granulocyte colony-stimulating factor (G-CSF) in its radioprotective efficacy against ionizing radiation in mice. MAIN METHODS:Multiplex Luminex was...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2014.01.065

    authors: Singh VK,Wise SY,Scott JR,Romaine PL,Newman VL,Fatanmi OO

    更新日期:2014-03-11 00:00:00

  • Central administration of 8-OH-DPAT and mCPP stimulates prolactin secretion in ovariectomized, estrogen-treated rats: lack of an effect on tuberoinfundibular dopaminergic neuron activity.

    abstract::The effects of central administration of two serotonin receptor agonists, 8-OH-DPAT and mCPP, on tuberoinfundibular dopaminergic (TIDA) neuron activity and serum prolactin (PRL) levels in ovariectomized, estrogen-treated rats were determined. 8-OH-DPAT dose-dependently (0.1-10 microgram/rat, icv) stimulated serum PRL ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(96)00077-x

    authors: Pan JT,Yang IC

    更新日期:1996-01-01 00:00:00

  • Hydrogen peroxide inhibits proliferation and endothelial differentiation of bone marrow stem cells partially via reactive oxygen species generation.

    abstract:AIMS:The present study was to investigate the effect of hydrogen peroxide (H2O2) on bone marrow stem cells and their endothelial differentiation and the underlying mechanisms in vitro. MAIN METHODS:Rat bone marrow multipotent adult progenitor cells (MAPCs) were used as the source of bone marrow stem cells, and treated...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2014.07.016

    authors: Xiao Y,Li X,Cui Y,Zhang J,Liu L,Xie X,Hao H,He G,Kander MC,Chen M,Liu Z,Verfaillie CM,Zhu H,Lei M,Liu Z

    更新日期:2014-09-01 00:00:00

  • The NMDA antagonist dizocilpine (MK801) attenuates motivational as well as somatic aspects of naloxone precipitated opioid withdrawal.

    abstract::The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine has recently been reported to antagonize certain overt withdrawal signs in morphine dependent rats. The purpose of the present study was to reassess this response and examine the effect of this drug in a model presumably reflective of the ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(92)90452-u

    authors: Higgins GA,Nguyen P,Sellers EM

    更新日期:1992-01-01 00:00:00

  • Study of bone repair mediated by recombination BMP-2/ recombination CXC chemokine Ligand-13-loaded hollow hydroxyapatite microspheres/chitosan composite.

    abstract:AIMS:The present study aimed to investigate the mechanism of bone repair mediated by recombination BMP-2 (rhBMP-2)/recombination CXC chemokine ligand-13 (rhCXCL13)-loaded hollow hydroxyapatite (HA) microspheres/chitosan (CS) composite. MATERIALS AND METHODS:Firstly, the biological activity of rhBMP-2 and rhCXCL13 rele...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2019.116743

    authors: Zeng J,Xiong S,Ding L,Zhou J,Li J,Qiu P,Liao X,Xiong L,Long Z,Liu S

    更新日期:2019-10-01 00:00:00

  • Identification of dynorphin 1-8 in human placenta by mass spectrometry.

    abstract::The human placental villus tissue contains opioid receptors and peptides. The opioid peptides extracted from the villus tissue were fractionated using reverse-phase high performance liquid chromatography and a radio-receptor assay. The presence of dynorphin 1-8 was corroborated by mass spectrometric production of (M +...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(87)90099-3

    authors: Ahmed MS,Randall LW,Sibai B,Dass C,Fridland G,Desiderio DM,Tolun E

    更新日期:1987-05-25 00:00:00

  • Hsa_circ_0029589 knockdown inhibits the proliferation, migration and invasion of vascular smooth muscle cells via regulating miR-214-3p and STIM1.

    abstract:AIMS:Circular RNAs (circRNAs) are relevant to atherosclerosis progression. However, the role and mechanism of circRNA hsa_circ_0029589 (circ_0029589) in atherosclerosis are not fully understood. This research aims to explore the function and mechanism of circ_0029589 in oxidized low-density lipoprotein (ox-LDL)-caused ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118251

    authors: Huang Z,Li P,Wu L,Zhang D,Du B,Liang C,Gao L,Zhang Y,Yao R

    更新日期:2020-10-15 00:00:00

  • Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes.

    abstract::Short-chain fatty acids (SCFA) are produced by fermentation of water-soluble fiber by anaerobic bacteria in the large bowel. Fiber-rich diets decrease the risk of developing inflammatory bowel disease (IBD) and butyrate enemas are effective as a therapy in some patients. Crohn's disease, one form of IBD, appears to in...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(03)00490-9

    authors: Cavaglieri CR,Nishiyama A,Fernandes LC,Curi R,Miles EA,Calder PC

    更新日期:2003-08-15 00:00:00

  • Effects of aortic coarctation on aortic antioxidant enzymes and NADPH oxidase protein expression.

    abstract::Abdominal aortic coarctation above the renal arteries leads to severe hypertension above the stenotic site and provides a model for simultaneous testing of the effects of increased and decreased pressure and consequently shear stress in the same animal. The effects of increased pressure, per se, on oxidative stress an...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2004.10.014

    authors: Sindhu RK,Roberts CK,Ehdaie A,Zhan CD,Vaziri ND

    更新日期:2005-01-07 00:00:00

  • Thalidomide and the immune system. 2. Changes in receptors on blood cells of a healthy volunteer.

    abstract::Thalidomide (Thd) was given in two trials (total daily dose: 5 or 8 mg Thd/kg body weight, respectively) for five and three days to a healthy male volunteer, and various receptors were analyzed on white blood cells before, during and after (up to 30 days) the treatment period. There were neither marked deviations in t...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(92)90162-i

    authors: Neubert R,Nogueira AC,Neubert D

    更新日期:1992-01-01 00:00:00

  • Acetone extract of Bupleurum scorzonerifolium inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing telomerase activity.

    abstract::Bupleuri radix, a traditional Chinese herb, has been widely used to treat liver diseases such as hepatitis and cirrhosis. The acetone extract of Bupleurum scorzonerifolium (AE-BS) showed a dose-dependently antiproliferative effect on the proliferation of A549 human lung cancer cells. The IC(50) of AE-BS, i.e., the con...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(03)00648-9

    authors: Cheng YL,Chang WL,Lee SC,Liu YG,Lin HC,Chen CJ,Yen CY,Yu DS,Lin SZ,Harn HJ

    更新日期:2003-09-19 00:00:00

  • P120-catenin regulates pulmonary fibrosis and TGF-β induced lung fibroblast differentiation.

    abstract::P120-catenin (P120) was known to function in adhesion between cells and signal transduction in many types of cells. In this study, we investigated the expression and role of P120 in pulmonary fibrosis and transforming growth factor beta (TGF-β) mediated lung fibroblast-to-myofibroblast differentiation (fibroblast diff...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2019.05.052

    authors: Zhang Y,Jiao H,Wu Y,Sun X

    更新日期:2019-08-01 00:00:00

  • Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin.

    abstract::Apigenin is one type of bioflavonoid widely found in citrus fruits, which possesses a variety of pharmacological actions on the central nervous system. A previous study showed that acute intraperitoneal administration of apigenin had antidepressant-like effects in the forced swimming test (FST) in ddY mice. To better ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2008.01.007

    authors: Yi LT,Li JM,Li YC,Pan Y,Xu Q,Kong LD

    更新日期:2008-03-26 00:00:00

  • U-54494A reduces 4-AP-induced afterdischarges of CA1 pyramidal cells in the hippocampal slice of the rat.

    abstract::The anticonvulsant activity of U-54494A was studied in a 4-aminopyridine (4-AP) epilepsy model using extracellular recordings in in vitro hippocampal slices. Field potentials were evoked by stimulation of Schaffer collaterals, and recorded from the CA1 region of the hippocampus after infusion of 4-AP in the absence an...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(92)90381-x

    authors: Camacho-Ochoa M,VonVoigtlander PF,Hoffmann WE,Piercey MP

    更新日期:1992-01-01 00:00:00

  • Lysine demethylase 5B suppresses CC chemokine ligand 14 to promote progression of colorectal cancer through the Wnt/β-catenin pathway.

    abstract:AIMS:Epigenetic and genetic alterations are crucial events in the onset and progression of human cancers including colorectal cancer (CRC). This work aims to probe the relevance of lysine demethylase 5B (KDM5B) to the progression of CRC and the possible molecules involved. MATERIALS AND METHODS:KDM5B expression in CRC...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118726

    authors: Yan G,Li S,Yue M,Li C,Kang Z

    更新日期:2021-01-01 00:00:00

  • Phosphoesterase complex modulates microflora and chronic inflammation in rats with alcoholic fatty liver disease.

    abstract::Phosphoesterase complex (Pho), a major active component of barley malt, has been demonstrated to be clinically effective in relieving alcoholic fatty liver disease (AFLD), and several lines of evidence have suggested that microbial dysbiosis, caused by chronic alcohol overconsumption, plays a key role in the progressi...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118509

    authors: Ma D,Hu J,Xu W,Wang Y,Wang J,Li L,Wang S,Zhou H,Li Y,Liu L

    更新日期:2020-12-01 00:00:00

  • Increased cold allodynia following intrathecal N-methyl-D-aspartate in rats with a mononeuropathy.

    abstract::NMDA receptors are involved in the modulation of neuropathic pain behavior and central sensitization. In vivo, this is mostly demonstrated by the use of specific antagonists such as MK801. Because studies evaluating the direct impact of spinal NMDA in neuropathic pain models are lacking, we performed a series of exper...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2004.10.068

    authors: Vissers KC,Hoffmann VL,Adriaensen HF,Heylen RJ,Meert TF

    更新日期:2005-06-10 00:00:00

  • Effect of 3,5,3'-triiodo-L-thyronine on amino acid accumulation and membrane potential in Sertoli cells of the rat testis.

    abstract::The purpose of this study was to investigate the effect of T3 on amino acid accumulation and on the membrane potential of Sertoli cells of immature rat testes. Testes of pre-pubertal and pubertal rats were pre-incubated (30 min) in Krebs-Ringer bicarbonate buffer and incubated in the presence of [14C]methylaminoisobut...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(01)01186-9

    authors: Silva FR,Leite LD,Barreto KP,D'Agostini C,Zamoner A

    更新日期:2001-07-13 00:00:00

  • Sensory neuropeptides modulate cigarette smoke-induced decrease in neutral endopeptidase activity in guinea pig airways.

    abstract::Cigarette smoke (CS) inhalation stimulates C-fibers to release sensory neuropeptides which mediate airway reflex responses to prevent irritants from entering the lower airways. When CS is inhaled via the upper airways, these airway defense responses may modulate the effect of CS on airway NEP activity and related airw...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(95)02210-a

    authors: Kuo HP,Lu LC

    更新日期:1995-01-01 00:00:00

  • Handling stress does not affect the expression of hepatic heat shock protein 70 and conjugation enzymes in rainbow trout treated with beta-naphthoflavone.

    abstract::A response in heat shock protein 70 (hsp 70) expression in the beta-naphthoflavone (BNF) treated rainbow trout (Oncorhynchus mykiss) corresponded to altered metabolic status of the liver as evidenced by the lower phosphoenolpyruvate carboxykinase (PEPCK), lactate dehydrogenase and 3-hydroxyacylcoA dehydrogenase activi...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(97)00366-4

    authors: Vijayan MM,Pereira C,Forsyth RB,Kennedy CJ,Iwama GK

    更新日期:1997-01-01 00:00:00

  • cAMP inhibits cytokine-induced biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells.

    abstract::We studied the effects of cAMP on cytokine (interferon-gamma plus tumor necrosis factor-alpha)-induced stimulation of tetrahydrobiopterin (BH4) synthesis in human umbilical vein endothelial cells (HUVEC). The cytokine mixture caused a marked increase in the biosynthesis and release of BH4 by HUVEC. Dibutyryl-cAMP prod...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(02)01503-5

    authors: Ohtsuki M,Shiraishi H,Kato T,Kuroda R,Tazawa M,Sumi-Ichinose C,Tada S,Udagawa Y,Itoh M,Hishida H,Ichinose H,Nagatsu T,Hagino Y,Nomura T

    更新日期:2002-03-22 00:00:00

  • Tumor angiogenesis and lymphangiogenesis: tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms.

    abstract::Tumor angiogenesis and lymphangiogenesis are key features of tumor progression and metastasis. The role of tumor cells-derived factors in the promotion of associated angiogenesis and lymphangiogenesis is much studied and, no doubt, very important for the understanding of cancer progression. This review aims to present...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2012.10.008

    authors: Gomes FG,Nedel F,Alves AM,Nör JE,Tarquinio SB

    更新日期:2013-02-07 00:00:00

  • Carcinostatic effects of platinum nanocolloid combined with gamma irradiation on human esophageal squamous cell carcinoma.

    abstract:AIMS:To explore the carcinostatic effects of platinum nanocolloid (Pt-nc) combined with gamma rays on human esophageal squamous cell carcinoma (ESCC). MAIN METHODS:ESCC-derived KYSE-70 cells were treated with various concentrations of Pt-nc and/or gamma irradiation, and subsequently cultured in phenol red free DMEM wi...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2015.01.028

    authors: Li Q,Tanaka Y,Saitoh Y,Tanaka H,Miwa N

    更新日期:2015-04-15 00:00:00

  • Differential penetration of three anterior pituitary peptide hormones into the cerebrospinal fluid of rhesus monkeys.

    abstract::This paper demonstrates marked differences between blood levels and those in the CSF for three anterior pituitary peptide hormones, prolactin, luteinizing hormone (LH) and adrenocorticotrophin (ACTH) in the rhesus monkey. CSF levels of endogenous prolactin (measured by radioimmunoassay) are about 20% of those in the b...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(83)90064-4

    authors: Dubey AK,Herbert J,Martensz ND,Beckford U,Jones MT

    更新日期:1983-04-18 00:00:00