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Tumor angiogenesis and lymphangiogenesis: tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms.

Abstract：

:Tumor angiogenesis and lymphangiogenesis are key features of tumor progression and metastasis. The role of tumor cells-derived factors in the promotion of associated angiogenesis and lymphangiogenesis is much studied and, no doubt, very important for the understanding of cancer progression. This review aims to present and discuss the work done on the pro-angiogenic and lymphangiogenic cellular interactions within the tumor microenvironment and the signaling pathways that regulate this crosstalk. Such multifactor studies are critical for the development of future therapeutic approaches for cancer because they take into account the complexities of cellular interactions within the tumor microenvironment.

journal_name

Life Sci

journal_title

Life sciences

authors

Gomes FG,Nedel F,Alves AM,Nör JE,Tarquinio SB

doi

10.1016/j.lfs.2012.10.008

subject

Has Abstract

pub_date

2013-02-07 00:00:00

pages

101-7

issue

2

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(12)00611-X

journal_volume

92

pub_type

杂志文章,评审

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