Abstract：
:The effects of ethanol on the production of oxygen-derived free radicals by neutrophils are controversial. Osmolarity-mediated alteration of cell volume appears to be an important mechanism for regulating neutrophil activity. We investigated in neutrophils from healthy volunteers the effect of isotonic/hypertonic ethanol on both chemiluminescence amplified by a Cypridina luciferin analog in response to N-formyl-Met-Lue-Phe and cell volume measured with a Coulter counter. Both isotonic and hypertonic ethanol significantly decreased chemiluminescence in a dose-dependent manner. Isotonic ethanol produced a greater magnitude of inhibition than hypertonic ethanol (P<0.01). Another permeable molecule, urea, and hypotonic solution had the same effects on chemiluminescence. Isotonic and hypertonic ethanol caused a prompt cell expansion and shrinking, respectively. On the other hand, isotonic sucrose, an impermeable molecule, was ineffective in both chemiluminescence and cell volume changes. These data suggest that isotonic ethanol inhibits the superoxide anion production by inducing cell expansion probably due to increased intracellular osmotic pressure caused by rapid ethanol permeation through the plasmalemma. This impaired neutrophil function may, in some part, contribute to the susceptibility to infection in alcoholics.
journal_name
Life Scijournal_title
Life sciencesauthors
Sato K,Sato N,Mori Mdoi
10.1016/s0024-3205(98)00396-8subject
Has Abstractpub_date
1998-01-01 00:00:00pages
1329-37issue
15eissn
0024-3205issn
1879-0631pii
S0024320598003968journal_volume
63pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Renal compensatory hypertrophy (RCH) occurs in hypothyroid rate, but it is impaired when compared to RCH found in euthyroid controls. It is due to cellular hypertrophy as the DNA content does not change and the Protein/DNA ratio increases in the compensating kidney. RCH is enhanced by thyroxine (T4) with a rise in the...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90278-8
更新日期：1982-02-15 00:00:00
abstract：:Two male adult rhesus monkeys were used and caged individually. The room was temperature-controlled having a light-dark period of 12/12 hours. The animals were rapidly immobilized and immediately anesthetized with ketamine i. m. (10 mg/kg of body weight). They were bled four times at 15, 30, 45 and 60 mins after the k...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90247-9
更新日期：1991-01-01 00:00:00
abstract：:This review analyses the knowledge about the incidence of transient apnoeic spells, induced by substances which activate vagal chemically sensitive afferents. It considers the specificity and expression of appropriate receptors, and relevant research on pontomedullary circuits contributing to a cessation of respiratio...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2018.12.021
更新日期：2019-01-15 00:00:00
abstract：:Physiological, pharmacological and toxicological responses to two regimens of cocaine administration were compared between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. An initial experiment examined renal excretory and hemodynamic function in response to an acute volume load in anesthetized SHR and WK...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90254-3
更新日期：1989-01-01 00:00:00
abstract：AIMS:Osteoblasts and adipocytes originate from common precursor cells. We examined the effects of bone morphogenetic protein-2 (BMP-2) on the molecular mechanisms governing the diametric actions of BMP-2 on simultaneous mature osteoblast and adipocyte differentiation in a clonal mesenchymal progenitor cell line, ROB-C2...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.12.011
更新日期：2009-02-27 00:00:00
abstract：AIMS:Data suggest pharmacological treatment of depression with selective serotonin reuptake inhibitors (SSRI) may impair bone health. Our group has previously modeled compromised craniofacial healing after treatment with sertraline, a commonly prescribed SSRI, and hypothesized potential culprits: alterations in bone ce...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117827
更新日期：2020-08-15 00:00:00
abstract：:An improved two-dimensional HPTLC procedure was developed for separating phospholipids including individual phosphoinositides, phosphatidic acids and plasmalogens. This procedure was used to examine the time course for uptake of label by phospholipids in brain subcellular membranes after intracerebral injection of [ga...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90475-x
更新日期：1989-01-01 00:00:00
abstract：AIMS:Honokiol is a natural product extracted from herbal plants such as the Magnolia species which have been shown to exhibit anti-tumor and anti-metastatic properties. However, the effects of honokiol on thyroid cancers are largely unknown. MATERIALS AND METHODS:To determine whether honokiol might be useful for the t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.06.002
更新日期：2018-08-15 00:00:00
abstract：:The effect of silymarin on different functions of mitochondria isolated from rat kidneys was studied. Addition of silymarin to mitochondria oxidizing succinate, induced stimulation of the respiratory State 4; while in mitochondria oxidizing NAD-dependent substrates, the drug produced inhibition of the oxygen consumpti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90542-5
更新日期：1988-01-01 00:00:00
abstract：AIMS:DNA methylation and hydroxymethylation are significantly related to the occurrence and development of coronary heart disease (CHD) and atherosclerosis (AS). 5-Methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) are used to assess DNA methylation and hydroxymethylation levels, respectively. However, 5-mC and ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.03.021
更新日期：2019-05-01 00:00:00
abstract：:This study demonstrates the formation of gamma-glutamyl peptides from glutamine and plasma amino acids, as catalyzed by gamma-glutamyl transpeptidase. It also establishes the effect of various amino acids in modulating the rate of glutamine utilization as well as the hydrolytic or transfer product formed. The mechanis...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90682-3
更新日期：1983-10-31 00:00:00
abstract：:To examine the direct effects of tributyltin acetate (TBTA) on osteoclasts and osteoblasts, teleost scale, which has both osteoclasts and osteoblasts and is similar to mammalian membrane bone, was used in the present study. The activities of tartrate-resistant acid phosphatase and alkaline-phosphatase, as respective i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.10.004
更新日期：2006-04-18 00:00:00
abstract：:The effects of thioperamide, an H3 antagonist, and histamine H1 and H2 antagonists (s.c.) on morphine (s.c. or i.c.v.)- and U-50,488H (i.c.v.)-induced antinociception in male ddY mice were examined using the hot-plate (55 degrees C) test. Thioperamide significantly inhibited morphine-induced antinociception, but not U...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00589-3
更新日期：1994-01-01 00:00:00
abstract：:Two alpha-adrenoceptor antagonists, phentolamine and 2-(beta-(4-hydroxyphenyl)-ethylaminomethyl)-tetralone (BE 2254) which are phenolic derivatives were radioiodinated after chloramine-T oxidation of Na125I and the labelled material isolated by chromatography. 125I-phentolamine does not bind selectively to alpha-adren...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90623-3
更新日期：1982-03-15 00:00:00
abstract：AIM:Nuclear factor-kappa B inhibitor alpha (IκBα) polymorphisms were found to be associated with inflammatory diseases. However, the association between IκBα polymorphisms with gastric cancer is still unknown. We aim to investigate the association between IκBα polymorphisms and gastric cancer risk in a large population...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.02.016
更新日期：2011-04-25 00:00:00
abstract：:The effect of nimodipine on nitric oxide synthase (NOS) activities in brains in transient focal cerebral ischemia rats, in cultured mouse neurons and astroglial cells and bovine brain capillary endothelial cells (BCECs) was investigated. The administration of nimodipine (3 mg.kg(-1), p.o., twice a day, for 3 days) bef...
journal_title：Life sciences
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:The systemic administration of neurotensin (NT) dose-dependently increased plasma adrenocorticotropin (ACTH) concentration in rats, and this effect was annulled by (alpha-helical)-CRH9-41, an antagonist of corticotropin-releasing hormone (CRH). The systemic administration of [D-Trp11]-neurotensin (NT-A), a specific NT...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90250-s
更新日期：1992-01-01 00:00:00
abstract：:MicroRNAs plays important role in the development of myocardial infarction (MI). The aim of this study was to analyze whether miR-429 has effect on the process of autophagy in myocardial anoxia/reoxygenation (AR) or ischemia/reperfusion (IR) injury and explore the underlying mechanism. The results showed that miR-429 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116842
更新日期：2019-10-15 00:00:00
abstract：:Ether à go-go (EAG) potassium channels possess oncogenic properties and have gained great interest as research tools for cancer detection and therapy. Besides, EAG electrophysiological properties are regulated through the cell cycle and determined by cytoskeletal interactions. Thus, because of the pivotal role of extr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.05.014
更新日期：2007-06-27 00:00:00
abstract：AIM:The aim of the present study was to assess and compare the effect of 17β-estradiol and two different selective estrogen receptor modulators (SERMs), tamoxifen and raloxifene, as well as a selective estrogen receptor alpha agonist, propyl-pyrazole-triol (PPT) and a selective estrogen receptor beta agonist, diarylpro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.03.010
更新日期：2011-05-09 00:00:00
abstract：AIMS:To evaluate potential agents of therapeutic value in tissue inflammation, we studied norcantharidin (NCTD) and its derivatives for their effects on immune responses of human peripheral blood mononuclear cells (PBMC) in vitro. MAIN METHODS:PBMC proliferation was evaluated by tritiated thymidine uptake method. The ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.11.020
更新日期：2009-02-13 00:00:00
abstract：AIM:Irisin, the adipomyokine, released mainly by exercised muscles, participate in the browning of adipose tissue and contribute to the restriction of insulin resistance and diabetes mellitus 2 development. Because of the limited reports describing the effect of irisin on inflammation and immunocompetent cells activati...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.03.011
更新日期：2017-05-01 00:00:00
abstract：:This study examines the role of dopaminergic mechanisms in the regulation of human pancreatic polypeptide (hPP) secretion in 11 normal male volunteers. Administration of domperidone (20 mg iv), an extracerebral inhibitor of dopamine receptors, resulted in a hPP rise (p less than 0.05) within 10 min and a peak response...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90063-7
更新日期：1982-12-27 00:00:00
abstract：:Oxymorphazone (at doses of 50-200 mg/kg) was found to be a relatively weak antinociceptive drug in intact frog (Rana esculenta) when acetic acid was used as pain stimulus. Frogs remained analgesic for at least 48 hrs following oxymorphazone (200 mg/kg) administration. The ligand increased the latency of wiping reflex ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90302-0
更新日期：1989-01-01 00:00:00
abstract：:Calcium ionophores, such as the A23187, cause endothelium-dependent relaxation of arterial strips with intact endothelium, whereas the effect of the ionophore should result from the combination of a relaxation caused by the endothelium-dependent factors and of a contraction of the smooth muscles. In addition, the appl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00646-9
更新日期：2000-06-23 00:00:00
abstract：:Cordyceps sinensis (C. sinensis) is one of the well known fungi used in traditional Chinese medicine for treatment asthma and bronchial and lung inflammation. In this study, effects of C. sinensis methanolic extracts on bronchoalveolar lavage fluids (BALF) cells proliferation, inflammatory cytokines production, and ge...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)01011-0
更新日期：2001-01-19 00:00:00
abstract：:Bupleuri radix, a traditional Chinese herb, has been widely used to treat liver diseases such as hepatitis and cirrhosis. The acetone extract of Bupleurum scorzonerifolium (AE-BS) showed a dose-dependently antiproliferative effect on the proliferation of A549 human lung cancer cells. The IC(50) of AE-BS, i.e., the con...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00648-9
更新日期：2003-09-19 00:00:00
abstract：:Hepatic tryptophan 2,3-dioxygenase (TDO) is one of the rate-limiting enzymes in tryptophan catabolism and plays an important role in regulating the physiological flux of tryptophan into relevant metabolic pathways. In this study, we determined the effect of the non-steroidal anti-inflammatory agents, tolmetin and suli...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.07.028
更新日期：2006-11-10 00:00:00
abstract：AIM:Evidence suggests that task-specific gait training improves locomotor impairments in people with incomplete spinal cord injury (SCI); however, plastic changes in brain areas remain poorly understood. The aim of this study was to examine the possible effects of a task-specific overground gait training on locomotor r...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116627
更新日期：2019-09-01 00:00:00
abstract：:The progeny of rats born and breastfed by mothers receiving dexamethasone (DEX) during pregnancy exhibits permanent reduction in body weight and adiposity but the precise mechanisms related to this programming are not fully understood. In order to clarify this issue, the present study investigated key aspects of lipop...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118765
更新日期：2021-01-15 00:00:00
