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Neurotensin enhances plasma adrenocorticotropin concentration by stimulating corticotropin-releasing hormone secretion.

Abstract：

:The systemic administration of neurotensin (NT) dose-dependently increased plasma adrenocorticotropin (ACTH) concentration in rats, and this effect was annulled by (alpha-helical)-CRH9-41, an antagonist of corticotropin-releasing hormone (CRH). The systemic administration of [D-Trp11]-neurotensin (NT-A), a specific NT antagonist, dose-dependently reduced the basal level of circulating ACTH, and this effect was blunted by NT injection. The ACTH inhibitory action of NT-A was completely overcome by the administration of CRH. Taken together, our findings suggest that NT plays a physiologic role in rats, as ACTH secretagogue, and that the mechanism underlying this action of NT involves the stimulation of CRH release.

journal_name

Life Sci

journal_title

Life sciences

authors

Nussdorfer GG,Malendowicz LK,Meneghelli V,Mazzocchi G

doi

10.1016/0024-3205(92)90250-s

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

639-43

issue

9

eissn

0024-3205

issn

1879-0631

pii

0024-3205(92)90250-S

journal_volume

50

pub_type

杂志文章

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