Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat.

abstract：:Coxsackievirus B3 (CVB3) is a major pathogen for acute and chronic viral myocarditis. The aim of this study was to investigate the antiviral effects of sophoridine, an alkaloid extracted from Chinese medicinal herb, Sophora flavescens, against CVB3, and the underlying pharmacokinetics. First, we determined the antivir...

journal_title：Life sciences

authors： Zhang Y,Zhu H,Ye G,Huang C,Yang Y,Chen R,Yu Y,Cui X

更新日期：2006-03-20 00:00:00

abstract：:The renal hemodynamic and tubular effects of ANF were investigated using the Sperber technique in chickens. This technique takes advantage of the unique portal circulation of the avian kidney and permits direct access to the renal peritubular space independent of renal arterial blood flow and glomerular filtration. In...

journal_title：Life sciences

authors： Springate JE,Fildes RD,Hong SK,Feld LG,Acara M

更新日期：1987-03-09 00:00:00

abstract：:Artemisinin is a promising and a potent antimalarial drug, which meets the dual challenge posed by drug-resistant parasites and rapid progression of malarial illness. This review article focuses on the progress achieved during the last years in the production of artemisinin from Artemisia annua. The structure, biosynt...

journal_title：Life sciences

authors： Dhingra V,Vishweshwar Rao K,Lakshmi Narasu M

更新日期：2000-01-01 00:00:00

abstract：AIM:Preparation of pegylated gold nanorods (PEG-AuNRs) that are capable of converting near infrared (NIR) light into heat. Evaluation of cancer therapeutic efficacy and long-term toxicity of the proposed photothermal therapy in comparison with other conventional modalities. MATERIALS AND METHODS:Prepared PEG-AuNRs wer...

journal_title：Life sciences

authors： Monem AS,Sayed FA,Rageh MM,Mohamed N

更新日期：2020-09-15 00:00:00

abstract：:A number of studies have been made on the role played by endogenous opioid peptides in the secretion of LH in humans. However no previous studies have compared the effects of the most potent pharmacological agonist and antagonist, morphine and naloxone, in the same subjects. The present study examined the acute effect...

journal_title：Life sciences

authors： Petraglia F,Porro C,Facchinetti F,Cicoli C,Bertellini E,Volpe A,Barbieri GC,Genazzani AR

更新日期：1986-06-09 00:00:00

abstract：AIMS:Osteoblasts and adipocytes originate from common precursor cells. We examined the effects of bone morphogenetic protein-2 (BMP-2) on the molecular mechanisms governing the diametric actions of BMP-2 on simultaneous mature osteoblast and adipocyte differentiation in a clonal mesenchymal progenitor cell line, ROB-C2...

journal_title：Life sciences

authors： Kato S,Kawabata N,Suzuki N,Ohmura M,Takagi M

更新日期：2009-02-27 00:00:00

abstract：:TCDD was assessed as a biological response modifier for increasing MMC cytotoxicity through aryl hydrocarbon receptor (AhR) activation and increasing levels of bioreductive enzymes. Human MCF-7 cells were exposed to TCDD, MMC and combinations thereof under aerobic or hypoxic conditions. Cytotoxicity, enzyme activities...

journal_title：Life sciences

authors： Collier AC,Pritsos KL,Pritsos CA

更新日期：2006-02-23 00:00:00

abstract：:Extracts of Hypericum perforatum (St. John's wort) have antidepressant properties in depressed patients and exert antidepressant-like action in laboratory animals. The phloroglucinol derivative hyperforin has become a topic of interest, as this Hypericum component is a potent inhibitor of monoamines reuptake. The mole...

journal_title：Life sciences

authors： Roz N,Rehavi M

更新日期：2003-06-13 00:00:00

abstract：:We investigated whether nitric oxide (NO) exposure alters the balance between NO and endothelium-derived hyperpolarizing factor (EDHF) released from rat renal arteries. To produce states of acutely or chronically excessive NO, lipopolysaccharide (LPS) was administered intraperitoneally to rats in a single dose of 4 mg...

journal_title：Life sciences

authors： Kagota S,Yamaguchi Y,Nakamura K,Shinozuka K,Kunitomo M

更新日期：2004-04-16 00:00:00

abstract：:The flavonoid quercetin exhibited a biphasic effect on calcium and phospholipid-dependent protein kinase (protein kinase C) activity from rat brain and pig thyroid. At a low concentration (10(-7) M) quercetin stimulated the enzyme activity whereas at higher concentrations quercetin was inhibitory. By contrast the synt...

journal_title：Life sciences

authors： Picq M,Dubois M,Munari-Silem Y,Prigent AF,Pacheco H

更新日期：1989-01-01 00:00:00

abstract：AIMS:it has been suggested that Chromium (Cr), one of the essential minerals, can be beneficial to type 2 diabetic patients because it lowers blood glucose levels by improving various steps in insulin action. A few studies reported that Cr might also have some beneficial effects in people with type 1 diabetes mellitus ...

journal_title：Life sciences

authors： Kwon MJ,Chung HS,Yoon CS,Ko JH,Jun HJ,Kim TK,Lee SH,Ko KS,Rhee BD,Kim MK,Park JH

更新日期：2010-09-25 00:00:00

abstract：AIMS:Sickle cell disease (SCD) pathogenesis leads to recurrent vaso-occlusive and hemolytic processes, causing numerous clinical complications including renal damage. As vasoconstrictive mechanisms may be enhanced in SCD, due to endothelial dysfunction and vasoactive protein production, we aimed to determine whether th...

journal_title：Life sciences

authors： dos Santos AF,Almeida CB,Brugnerotto AF,Roversi FM,Pallis FR,Franco-Penteado CF,Lanaro C,Albuquerque DM,Leonardo FC,Costa FF,Conran N

更新日期：2014-11-04 00:00:00

abstract：AIM:Betel-nut, a popular masticatory among Southeast Asian populations is a class I carcinogen, previously associated with dyslipidemia and aberrant lipid metabolism, and is reported to be used more frequently by females, than males. This study investigates the potential of repurposing the anti-diabetic drug, vildaglip...

journal_title：Life sciences

authors： Nath M,Bhattacharjee K,Choudhury Y

更新日期：2021-02-01 00:00:00

abstract：:Depression is a leading cause of disability worldwide. However, the biological and molecular mechanisms underlying this disease remain unclear. Stress, a disposing factor in the development of depression, leads to hypothalamic-pituitary-adrenal (HPA) axis activation and glucocorticoids release. Glucocorticoids at phys...

journal_title：Life sciences

authors： Chen J,Wang ZZ,Zhang S,Zuo W,Chen NH

更新日期：2016-05-01 00:00:00

abstract：:1-Aminocyclopropane carboxylic acid (ACPC), a partial agonist of the glycine site on the NMDA receptor, prevents tolerance to the mu opioid morphine and the delta ligand [D-Pen2,D-Pen5]enkephalin (DPDPE) when co-administered with the opioid. In contrast, ACPC does not significantly influence tolerance to the kappa1 op...

journal_title：Life sciences

authors： Kolesnikov YA,Maccechini ML,Pasternak GW

更新日期：1994-01-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA), an adrenal steroid of no known biological function, is a potent inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). DHEA inhibited the growth of two stains of HeLa and WI-38 cells in culture. One of the HeLa strains, TCRC-2, was about 10x as sensitive to growth inhibition a...

journal_title：Life sciences

authors： Dworkin CR,Gorman SD,Pashko LL,Cristofalo VJ,Schwartz AG

更新日期：1986-04-21 00:00:00

abstract：:Fluorescence spectroscopy was used to examine the biophysical characteristics of human platelet membranes as a function of subject age. The structural order of membrane lipid domains was determined with the use of 1,6-diphenyl-1,3,5-hexatriene (DPH), a fluorescent probe that preferentially localizes in the hydrocarbon...

journal_title：Life sciences

authors： Cohen BM,Zubenko GS

更新日期：1985-10-14 00:00:00

abstract：:Initial acute behavioral studies in mice indicated that phencyclidine (PCP) produced marked motor impairment as measured by the inverted screen technique with an ED50 value of 4.1 muMole/kg (i.v.). Phenylcyclohexene (PC) was considerably less active with an ED50 value of 325 muMole/kg (i.v.). PCP was also shown to be ...

journal_title：Life sciences

authors： Holsapple MP,Munson AE,Freeman AS,Martin BR

更新日期：1982-08-23 00:00:00

abstract：:Since the late 1960's, radioenzymatic assays have gradually come to replace the less sensitive and less specific spectrofluorometric and bioassay procedures previously used to determine many of the neurotransmitters. These assays provide the means to measure picogram quantities of most of these substances, and have en...

journal_title：Life sciences

authors： Philips SR

更新日期：1987-08-17 00:00:00

abstract：:Glycation-modified hemoglobin in diabetes mellitus has been suggested to be a source of enhanced catalytic iron and free radicals causing pathological complications. The present study aims to verify this idea in experimental diabetes. Pelargonidin, an anthocyanidin, has been tested for its antidiabetic potential with ...

journal_title：Life sciences

authors： Roy M,Sen S,Chakraborti AS

更新日期：2008-05-23 00:00:00

abstract：:The metabolism of haloperidol (HP) to the potentially neurotoxic pyridinium species, HPP+ and RHPP+, has been demonstrated in humans. In vitro studies in microsomes harvested from various animal species indicate that the tetrahydropyridines, HPTP and RHPTP, could be intermediates in this pathway. However, this has not...

journal_title：Life sciences

authors： Avent KM,Riker RR,Fraser GL,Van der Schyf CJ,Usuki E,Pond SM

更新日期：1997-01-01 00:00:00

abstract：:Bradykinin receptor stimulation results in G-protein-coupled phospholipase activation, initiating protein kinase C (PKC) stimulation and cytosolic free Ca2+ concentration ([Ca2+]i) rises as signalling pathways. Using Rb+ as a tracer for K+, we have studied the mechanisms involved in bradykinin-stimulated Rb+ influx in...

journal_title：Life sciences

authors： Hichami A,Anger JP,Allain N,Vernhet L,Martin CA,Legrand AB

更新日期：1996-01-01 00:00:00

abstract：:Early induction of VEGF was studied in liver, kidney and lung of spontaneously diabetic rats. Western blot analysis, northern hybridization were applied to show the expression of VEGF in different organs. Radiolabelled hypoxia responsive element (HRE) and cAMP responsive element (CRE) oligonucleotides were assayed by ...

journal_title：Life sciences

authors： Braun L,Kardon T,Reisz-Porszasz ZS,Banhegyi G,Mandl J

更新日期：2001-10-12 00:00:00

abstract：AIM:We previously reported the possible involvement of mucosal nitric oxide (NO)-triggered 5-HT release in luminal glutamate sensing by the gastric vagus nerve, and we proposed that the stomach, like the duodenum, could "taste" luminal nutrients. Nitric oxide synthase (NOS) is widely distributed in the gastric mucosa, ...

journal_title：Life sciences

authors： Uneyama H,Niijima A,Kitamura A,Torii K

更新日期：2009-12-16 00:00:00

abstract：:Acetylcholine (ACh) may be an ovarian signaling molecule, since ACh is produced by non-neuronal granulosa cells (GCs) derived from the antral follicle, and likely also by their in vivo counterparts in the growing follicle. Furthermore, muscarinic ACh receptors (MR) are present in GC membranes and in cultured human GCs...

journal_title：Life sciences

authors： Kunz L,Roggors C,Mayerhofer A

更新日期：2007-05-30 00:00:00

abstract：:It was recently reported that vitamin C (500 mg/day for 6 weeks) administered as a dietary supplement to healthy humans exhibits a prooxidant, as well as an antioxidant effect in vivo. Here we show that high intakes of vitamin C (500 mg/kg b.w. for 4 days) in the rat are able to markedly induce hepatic cytochrome P450...

journal_title：Life sciences

authors： Paolini M,Pozzetti L,Pedulli GF,Marchesi E,Cantelli-Forti G

更新日期：1999-01-01 00:00:00

abstract：:Morphine and oxycodone are potent opioid analgesics most commonly used for the management of moderate to severe acute and chronic pain. Their clinical utility is limited by undesired side effects like analgesic tolerance, dependence, and withdrawal. We have previously demonstrated that endothelin-A (ETA) receptor anta...

journal_title：Life sciences

authors： Bhalla S,Andurkar SV,Gulati A

更新日期：2016-08-15 00:00:00

abstract：:The concept of food has expanded beyond its traditional role of survival and hunger satisfaction, to include a role in the prevention and treatment of disease. Polyphenols are classes of compounds that are synthesized by plants to serve a wide variety of functions including growth pollination and defense. These compou...

journal_title：Life sciences

authors： Raj P,Louis XL,Thandapilly SJ,Movahed A,Zieroth S,Netticadan T

更新日期：2014-01-30 00:00:00

abstract：:"Bath salts" is one street name for a family of synthetic cathinones that display pharmacological effects resembling cocaine and commonly abused amphetamines. Despite extensive legislation aimed at the criminalization of bath salts, several designer cathinones are gaining a foothold in the illicit drug scene; for exam...

journal_title：Life sciences

authors： Gregg RA,Rawls SM

更新日期：2014-02-27 00:00:00

abstract：:Bacterial infection can negatively affect different parts of the male genital tract and subsequently cause impaired spermatogenesis and male fertility. However, most of the previous studies have focused on the infected organs of the male genital tract and there are not many studies that investigated the direct effect ...

journal_title：Life sciences

authors： Oghbaei H,Rastgar Rezaei Y,Nikanfar S,Zarezadeh R,Sadegi M,Latifi Z,Nouri M,Fattahi A,Ahmadi Y,Bleisinger N

更新日期：2020-09-01 00:00:00