Abstract：
:It was recently reported that vitamin C (500 mg/day for 6 weeks) administered as a dietary supplement to healthy humans exhibits a prooxidant, as well as an antioxidant effect in vivo. Here we show that high intakes of vitamin C (500 mg/kg b.w. for 4 days) in the rat are able to markedly induce hepatic cytochrome P4502E1-linked monooxygenases, measured as p-nitrophenol hydroxylase activity and corroborated by means of Western blot analyses. Furthermore, using Electron Paramagnetic Resonance Spectroscopy (EPR) coupled to a spin-trapping technique, we have also found that this induction generates large amounts of the anion radical superoxide (O2-). Therefore we can conclude that the adverse prooxidant outcomes (i.e. oxidative DNA damage) associated to vitamin C supplementation, being associated to a typical reversible boosting effect (i.e. enzymatic induction), may be easily controlled by a discontinuous supply. However, since the induced P4502E1 isoforms by vitamin C are responsible for ethanol metabolism to highly reactive radicals, care should be taken even in moderate drinkers.
journal_name
Life Scijournal_title
Life sciencesauthors
Paolini M,Pozzetti L,Pedulli GF,Marchesi E,Cantelli-Forti Gdoi
10.1016/s0024-3205(99)00167-8subject
Has Abstractpub_date
1999-01-01 00:00:00pages
PL 273-8issue
23eissn
0024-3205issn
1879-0631pii
S0024320599001678journal_volume
64pub_type
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