Abstract：
:Depression is a leading cause of disability worldwide. However, the biological and molecular mechanisms underlying this disease remain unclear. Stress, a disposing factor in the development of depression, leads to hypothalamic-pituitary-adrenal (HPA) axis activation and glucocorticoids release. Glucocorticoids at physiological concentrations activate two types of steroid receptors including the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR). During the past decades, lots of studies have confirmed the role of GR in depression. An increasing number of studies, in recent years, indicate that abnormal function of MR is also a crucial component of the pathophysiology of depression. Thus, this review summarizes the role of MR in the HPA axis dysregulation, inflammation, decreased neurogenesis and stress-related behaviors in depression. All of which will provide more information about MR in depression.
journal_name
Life Scijournal_title
Life sciencesauthors
Chen J,Wang ZZ,Zhang S,Zuo W,Chen NHdoi
10.1016/j.lfs.2016.03.022subject
Has Abstractpub_date
2016-05-01 00:00:00pages
76-81eissn
0024-3205issn
1879-0631pii
S0024-3205(16)30175-8journal_volume
152pub_type
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