Abstract：
:Among hepatic diseases, cholestatic ductopenic cholangiopathies are poorly studied, and they are rarely given the importance they deserve, especially considering their high incidence in clinical practice. Although cholestatic ductopenic cholangiopathies have different etiologies and pathogenesis, all have the same target (the cholangiocyte) and similar mechanistic basis of cell death. Cholestatic cholangiopathies are characterized, predominantly, by obstructive or functional damage in the biliary epithelium, resulting in an imbalance between proliferation and cholangiocellular death; this leads to the progressive disappearance of bile ducts, as has been shown to occur in primary sclerosing cholangitis, primary biliary cholangitis, low-phospholipid-associated cholelithiasis syndrome, cystic fibrosis-related liver disease, and drug-induced ductopenia, among other biliary disorders. This review summarizes the features of the more common ductopenic syndromes and the cellular mechanisms involved in cholengiocellular death, with focus on the main forms of cholangiocyte death described so far, namely apoptosis, autophagy, necrosis, and necroptosis. It also emphasizes the importance to study in depth the molecular mechanisms of cholengiocyte death to make possible to counteract them with therapeutic purposes. These therapeutic strategies are limited in number and efficacy at present, and this is why it is important to find complementary, safe strategies to stimulate cholangiocellular proliferation in order favor bile duct replenishment as well. Successful in finding appropriate treatments would prevent the patient from having liver transplantation as the only therapeutic alternative.
journal_name
Life Scijournal_title
Life sciencesauthors
Salas-Silva S,Simoni-Nieves A,Lopez-Ramirez J,Bucio L,Gómez-Quiroz LE,Gutiérrez-Ruiz MC,Roma MGdoi
10.1016/j.lfs.2018.12.044subject
Has Abstractpub_date
2019-02-01 00:00:00pages
324-339eissn
0024-3205issn
1879-0631pii
S0024-3205(18)30837-3journal_volume
218pub_type
杂志文章,评审相关文献
LIFE SCIENCES文献大全abstract：:Nitric oxide (NO) may be an intercellular modulator within the central nervous system. L-arginine, which results in NO synthesis, increased food intake in mice while the inhibitor of NO synthesis, L-NG-nitro arginine (L-NO Arg) inhibited food intake in food deprived mice. L-arginine, but not D-arginine, partially reve...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90102-h
更新日期：1991-01-01 00:00:00
abstract：:The loss of gamma-aminobutyric acid (GABA)-ergic medium spiny neurons (MSNs) in the striatum is the hallmark of Huntington disease (HD), an incurable neurodegenerative disorder characterized by progressive motor, psychiatric, and cognitive symptoms. Transplantation of MSNs or their precursors represents a promising tr...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2018.07.030
更新日期：2018-09-15 00:00:00
abstract：:This study was undertaken to compare the activity of muscarinic and beta adrenergic receptors in bovine peripheral lung to the corresponding receptor activity in tracheal smooth muscle. We used [3H] quinuclidinyl benzilate (QNB) and [3H]dihydroalprenolol (DHA) to measure muscarinic and beta receptor activity, respecti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90449-0
更新日期：1982-06-14 00:00:00
abstract：:The pure estrogen antagonist ICI-182780, at doses above 50 micrograms/kg, effectively inhibited the initiation of embryo implantation in rats when administered on day 4 of pregnancy (day 1 = sperm positive). The same dose inhibited the implantation initiating effect of intravenous 25 ng of estradiol-17 beta in delayed...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90186-7
更新日期：1993-01-01 00:00:00
abstract：:Hypertension is closely associated with vascular endothelial dysfunction. The aim of this study was to investigate the effects of Angiotensin II (ANG II) receptor antagonist losartan on the blood-brain barrier (BBB) permeability in L-NAME-induced hypertension and/or in ANG II-induced acute hypertension in normotensive...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01772-1
更新日期：2002-07-12 00:00:00
abstract：:In this paper, we describe the characterization of the expression of monoamine oxidase (MAO) in whole pancreas and in isolated islets of Langerhans from human. Classical monamine oxidase activity assays reveal that both isoforms A & B are present in human pancreas. Two complementary approaches indicated that both MAO ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00265-9
更新日期：1999-01-01 00:00:00
abstract：:Adrenals of young adult male mice kept on a LD 12:12 lighting regimen for three weeks prior to study and harvested at four different circadian stages were incubated for 2 hours with 0.4 IU synthetic ACTH in 2 ml Krebs-Ringer buffer (KR), or with 50, 150, and 450 microM of melatonin in KR containing 0.4 IU ACTH. The ad...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00079-3
更新日期：1996-01-01 00:00:00
abstract：:In vivo microdialysis was used to investigate the effects of acute injections of norharman on extraneuronal concentrations of dopamine (DA) in the nucleus accumbens of rats. Administration of norharman (2.44 and 43.97 mumol/kg, i.p.) elicited an increase of the DA efflux by 70% and 160% respectively which returned to ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)98578-4
更新日期：1995-01-01 00:00:00
abstract：:A heterogeneous particulate fraction of mouse brain homogenates binds NRDC 157 (3-phenoxybenzyl [1R, cis]-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate), a potent pyrethroid insecticide, stereospecifically and with high affinity. Stereospecific binding is a minor component of total binding (2.8%); the remai...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90385-5
更新日期：1983-07-18 00:00:00
abstract：:The COVID-19 pandemic raised by SARS-CoV-2 is a public health emergency. However, lack of antiviral drugs and vaccine against human coronaviruses demands a concerted approach to challenge the SARS-CoV-2 infection. Under limited resource and urgency, combinatorial computational approaches to identify the potential inhi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118080
更新日期：2020-09-15 00:00:00
abstract：:Amyloid beta-protein (A beta), the major protein of cerebrovascular and plaque amyloid in Alzheimer disease, is considered a primary factor in the pathology of this disease. The effect of synthetic A beta (1-40) on the activity of protein kinase C (PKC) was studied with histones for a substrate in a mixed micellar ass...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90328-9
更新日期：1991-01-01 00:00:00
abstract：AIMS:This study aims to evaluate the relationship between the amount of physical activity and different traditional and novel cardiometabolic risk factors, as well as atheroprotective agents, in male children and adolescents. MAIN METHODS:Cross-sectional study. A total of 337 male children and adolescents aged 7-14 ye...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.05.021
更新日期：2013-07-30 00:00:00
abstract：AIMS:Data suggest pharmacological treatment of depression with selective serotonin reuptake inhibitors (SSRI) may impair bone health. Our group has previously modeled compromised craniofacial healing after treatment with sertraline, a commonly prescribed SSRI, and hypothesized potential culprits: alterations in bone ce...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117827
更新日期：2020-08-15 00:00:00
abstract：AIMS:Gastrointestinal cancers are a kind of deadly malignancy afflicting close to a million peoples worldwide. 5-Fluorouracil (5-Fu) is a main chemotherapeutic agent for cancer treatment. However, prolonged exposure of 5-Fu to cancer cells may cause chemoresistance and decrease the therapeutic potential of 5-Fu. MAIN ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.03.054
更新日期：2018-05-15 00:00:00
abstract：AIMS:Osteoclasts, the unique bone-resorbing polykaryons, are responsible for many bone-destructive diseases, such as osteoporosis and rheumatoid arthritis. Hence, the regulation of osteoclast formation is considered a potential therapeutic approach for these diseases. In this study, we investigated the effect of a nove...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.09.009
更新日期：2012-11-02 00:00:00
abstract：:Thirty-seven women, aged 31-78 years, on two separate mornings consumed a decaffeinated beverage to which 6 mg caffeine/kg lean body mass or no caffeine were added. Total urine output of water, calcium, magnesium, sodium, chloride, potassium and creatinine increased in the two hours following caffeine ingestion when c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90616-y
更新日期：1990-01-01 00:00:00
abstract：:The temperature effects of naloxone and naltrexone (1-30 mg/kg) were examined in well habituated male rats. These drugs had a similar time course and potency, producing a dose-dependent hypothermia followed several hours later by a hyperthermia. A subsequent study found that not only did 30 mg/kg of naloxone or naltre...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90563-7
更新日期：1987-03-16 00:00:00
abstract：INTRODUCTION AND AIM:Polycystic ovary syndrome is one of the most common causes of female infertility, affecting 5-10% of the population. Women with PCOS manifest hyperandrogenism, hyperinsulinemia, low-grade systemic inflammation, and polycystic ovaries. Unfortunately, current available medications are only symptomati...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116640
更新日期：2019-09-01 00:00:00
abstract：AIMS:Oncogenic RET/PTC1 chromosomal rearrangements are hallmarks of thyroid papillary carcinoma. The resulting protein, mainly through tyrosine 451, is responsible for the activation of pathways controlling cell survival, including the PI3K/Akt/mTOR cascade. Vanadium compounds were shown to have anti-neoplastic potenti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.07.004
更新日期：2011-09-12 00:00:00
abstract：:The traditional Chinese medicines have been used clinically for a long time in some Asian countries, however, very few studies have been done to demonstrate the working mechanisms of these medicines using recently developed biochemical methodologies. In this study, we examined the anti-inflammatory effect of Huang-Lia...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00557-3
更新日期：2000-01-01 00:00:00
abstract：AIMS:To examine the role of trypsin in the immune response of macrophages and to determine whether protease-activated receptors (PARs) are involved in the effects of trypsin. MAIN METHODS:We used RAW264.7 cells and peritoneal macrophages isolated from C57BL/6 wild-type mice, PAR2 knockout mice, and ddY mice. Macrophag...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.06.030
更新日期：2012-08-21 00:00:00
abstract：:Current treatment of Alzheimer's Disease (AD) requires acetylcholinesterase inhibition to increase acetylcholine (ACh) concentrations in the synaptic cleft. Another mechanism by which ACh levels can be increased is blockade of presynaptic M2 muscarinic autoreceptors that regulate ACh release. An antagonist designed fo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01056-6
更新日期：2001-04-27 00:00:00
abstract：AIMS:The aim of the present study was to characterize TRPV4 channels in pregnant and nonpregnant mouse uterus and examine their functional role in spontaneous and agonist-induced contractions. MAIN METHODS:We used RT-PCR, Western blot and immunohistochemistry experiments to demonstrate the presence of TRPV4 mRNA and p...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.12.010
更新日期：2015-02-01 00:00:00
abstract：:The biochemical integrity of hepatocellular mitochondria was investigated in rats treated with small doses of human recombinant tumor necrosis factor-alpha (Hur-TNF;50-100 micrograms/kg/d injected intraperitoneally for 5 d) by measuring the activities of three mitochondrial enzymes, glutamate dehydrogenase, succinate ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00495-e
更新日期：1995-01-01 00:00:00
abstract：:The nonsteroidal anti-inflammatory drug zomepirac (ZP) is metabolised to a chemically reactive acyl glucuronide conjugate (ZAG) which can form covalent adducts with proteins. In vivo, such adducts could initiate immune or toxic responses. In rats given ZP, the major band detected in liver homogenates by immunoblotting...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00981-4
更新日期：2001-01-05 00:00:00
abstract：:Recent studies suggest that protein kinase C and, thus, possibly the rate of inositol phospholipid hydrolysis may regulate the function and distribution of the asialoglycoprotein (or galactosyl) receptor on isolated rat hepatocytes (Takahashi et al., Biochem. Biophys. Res. Commun., 1985, 126, 1054; Fallon and Schwartz...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90110-0
更新日期：1989-01-01 00:00:00
abstract：:Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by symptoms that include social communication impairments, interaction deficits, and repetitive and stereotyped behaviors. Recent studies have suggested that imbalanced cytokine levels are associated with impaired behavioral outcomes in ind...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116930
更新日期：2019-11-15 00:00:00
abstract：:We have proposed that the atypical opioid system in the mouse may be representative of that in the anorexia nervosa patient and may account for a biological predisposition to the disorder. This is in the context of our auto-addiction model of anorexia nervosa in which endogenous opioids play a critical role in its eti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90521-r
更新日期：1990-01-01 00:00:00
abstract：:Abnormal activation of the beta-catenin signaling pathway can cause various types of cancer. Activation of Wnt pathway leads to stabilization of the beta-catenin protein, which results in its translocation to the nucleus and the formation of complexes with lymphoid enhancer factor-1 (LEF-1) and other T-cell factor (TC...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.02.009
更新日期：2005-07-29 00:00:00
abstract：:Guinea pig ileum longitudinal muscle/myenteric plexus preparations contain functional mu- and kappa-opioid receptors. A preparation with blocked kappa receptors was obtained by pretreating guinea pigs with 0.1-10.0 mg/kg intraperitoneal doses of a new kappa-selective affinity label, DIPPA (2-(3,4-dichlorophenyl)-N-met...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00076-3
更新日期：1997-01-01 00:00:00
