Abstract：
:In vivo microdialysis was used to investigate the effects of acute injections of norharman on extraneuronal concentrations of dopamine (DA) in the nucleus accumbens of rats. Administration of norharman (2.44 and 43.97 mumol/kg, i.p.) elicited an increase of the DA efflux by 70% and 160% respectively which returned to basal levels after 120 and 160 min respectively. In contrast, administration of an intermediate dose of norharman (7.33 umol/kg, i.p.) elicited a significant decrease to 72% of basal level. These findings indicate that norharman alters the activity of mesolimbic dopaminergic neurons in an U-shape manner. The observations further suggest several receptor mechanisms mediating the effects of norharman.
journal_name
Life Scijournal_title
Life sciencesauthors
Baum SS,Hill R,Rommelspacher Hdoi
10.1016/0024-3205(95)98578-4subject
Has Abstractpub_date
1995-01-01 00:00:00pages
1715-20issue
20eissn
0024-3205issn
1879-0631pii
0024320595985784journal_volume
56pub_type
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