Evidence for a model of activation of central sigma systems.

abstract：:Our recent report demonstrated that apoptosis-specific autoantibodies against granzyme B-induced cleavage fragments of SS-B (La) were found in the sera from patients with primary Sjögren's syndrome. The objective of this study was identified by the intracellular redistribution of La autoantigen during granzyme B-induc...

journal_title：Life sciences

authors： Huang M,Ida H,Arima K,Nakamura H,Aramaki T,Fujikawa K,Tamai M,Kamachi M,Kawakami A,Yamasaki H,Origuchi T,Eguchi K

更新日期：2007-10-27 00:00:00

abstract：AIMS:The present study was designed to compare the effects of a low-fat diet (LF), calorie restriction (CR), quercetin (Que) and exercise (Ex) on hepatic steatosis in a high-fat (HF) diet-induced obesity prone (OP) model in the perspective of microRNA (miR)-dependent thyroid hormone (TH) synthesis and action. MAIN MET...

journal_title：Life sciences

authors： Xia SF,Jiang YY,Qiu YY,Huang W,Wang J

更新日期：2020-02-01 00:00:00

abstract：:We examined the effect of 7-OH-DPAT on spontaneous locomotor activity that is enhanced in diabetic mice. 7-OH-DPAT (0.1-30 mg/kg, s.c.) dose-dependently decreased the enhanced spontaneous locomotor activity in diabetic mice, but not in nondiabetic mice. When mice were pretreated with of 7-OH-DPAT (0.1 mg/kg), morphine...

journal_title：Life sciences

authors： Kamei J,Saitoh A

更新日期：1996-01-01 00:00:00

abstract：:This study in conscious normotensive rats was performed to assess the effect of the vasoconstrictor peptide, neuropeptide Y (NPY), on blood pressure responsiveness to exogenous norepinephrine in endotoxaemia. NPY and endotoxin were infused at doses which had no effect on blood pressure, whether given alone or in combi...

journal_title：Life sciences

authors： Evéquoz D,Waeber B,Corder R,Nussberger J,Gaillard R,Brunner HR

更新日期：1987-12-07 00:00:00

abstract：:Nucleotides, e.g. ATP and ADP, are important signaling molecules, which elicit several biological responses. The degradation of nucleotides is catalyzed by a family of enzymes called NTPDases (nucleoside triphosphate diphosphohydrolases). The present study reports the enzymatic properties of a NTPDase (CD39, apyrase, ...

journal_title：Life sciences

authors： Rico EP,Senger MR,Fauth Mda G,Dias RD,Bogo MR,Bonan CD

更新日期：2003-09-05 00:00:00

abstract：AIM:Diabetic nephropathy (DN) is a leading cause of end-stage renal disease, and thus, the ability of antidiabetic drugs to ameliorate renal microvascular disease may be as important as their ability to control blood glucose. Therefore, we investigated the reno-protective effect of the antidiabetic drugs, Sitagliptin a...

journal_title：Life sciences

authors： Ali SM,Khalifa H,Mostafa DK,El Sharkawy A

更新日期：2016-05-15 00:00:00

abstract：:The binding characteristics of the sigma-1 selective benzomorphan [3H]-(+)-pentazocine were determined in human cerebellar membranes. Saturation binding analysis revealed two affinity sites with a KDH of 1.4 +/- 0.7 nM and a KDL of 33.6 +/- 11.9 nM. Kinetic studies performed at 25 degrees C demonstrated reversible bin...

journal_title：Life sciences

authors： Zabetian CP,Staley JK,Flynn DD,Mash DC

更新日期：1994-01-01 00:00:00

abstract：:The in vivo effect of trazodone on the density of [(3)H]5-HT binding sites and 5-HT(1A) receptors and adenylyl cyclase (AC) response was studied in regions of rat brain. The chronic administration of trazodone (10 mg/Kg body wt, 40 days) resulted in a significant downregulation of [(3)H]5-HT binding sites and 5-HT(1A)...

journal_title：Life sciences

authors： Subhash MN,Srinivas BN,Vinod KY

更新日期：2002-08-16 00:00:00

abstract：:Exposure to Cd(2+) via inhalation or intratracheal instillation results in pulmonary edema, which is followed by the influx of leukocytes, the proliferation of type II pneumocytes and eventual scarring and fibrotic changes. While the general toxic effects of Cd(2+) in the lung have been well characterized, the specifi...

journal_title：Life sciences

authors： Pearson CA,Lamar PC,Prozialeck WC

更新日期：2003-01-31 00:00:00

abstract：:Neuropathic pain syndromes respond poorly to opioid treatment. In our previous studies, we found that intrathecal (i.t.) injection of pertussis toxin (PTX) produces thermal hyperalgesia, which is poorly responsive to morphine and is accompanied by an increase in cerebrospinal fluid (CSF) levels of excitatory amino aci...

journal_title：Life sciences

authors： Wu GJ,Wen ZH,Chang YC,Yang SN,Tao PL,Wong CS

更新日期：2006-03-13 00:00:00

abstract：:The effects of chronic treatment with antidepressants, verapamil, or lithium on serotonin (5-HT)-induced Ca2+ increase were investigated in single C6BU-1 glioma cells with digital imaging microscopy. Clomipramine and citalopram, at a concentration of 100 nM, decreased the peak values of 5-HT-induced [Ca2+]i changes. V...

journal_title：Life sciences

authors： Yamaji T,Kagaya A,Uchitomi Y,Yokota N,Yamawaki S

更新日期：1997-01-01 00:00:00

abstract：AIMS:Oxaliplatin (l-OHP) is a key drug in therapeutic regimens for metastatic or advanced-stage colorectal cancer, but causes peripheral neuropathy as a dose-limiting adverse effect. It is reported that this peripheral neuropathy results from l-OHP accumulation in dorsal root ganglion (DRG) neurons, and that one of the...

journal_title：Life sciences

authors： Nishida K,Takeuchi K,Hosoda A,Sugano S,Morisaki E,Ohishi A,Nagasawa K

更新日期：2018-08-15 00:00:00

abstract：:Triiodothyronine (T3) and estrogen (E2) play important roles in the bone remodeling process and signaling of receptor activator of the nuclear factor-kappa β (RANKL) and osteoprotegerin (OPG) expressed by osteoblasts. However, little is known of the molecular action of these hormones in conditions of hyperthyroidism a...

journal_title：Life sciences

authors： Olímpio RMC,Moretto FCF,De Sibio MT,de Oliveira M,Mathias LS,Gonçalves BM,Deprá IC,Tilli HP,Rodrigues BM,Saraiva PP,Maria DA,Nogueira CR

更新日期：2019-08-15 00:00:00

abstract：:The effects of 1,3-dipropyl-8(p-sulfophenyl)xanthine (DPSPX) and enprofylline on the respiratory responses to bilateral occlusions of the common carotid arteries (CCO) were studied in rats anesthetized with sodium pentobarbitone and breathing spontaneously. CCO during periods of 5, 10 and 15 s caused increases in tida...

journal_title：Life sciences

authors： Monteiro EC,Ribeiro JA

更新日期：1989-01-01 00:00:00

abstract：AIMS:Normal human cells in culture progressively lose their capacity for replication, ending in an irreversible arrested state known as replicative senescence. Senescence has been functionally associated to the process of organismal ageing and is also considered a major tumor-suppressing mechanism. Although a great dea...

journal_title：Life sciences

authors： Maeda M,Scaglia N,Igal RA

更新日期：2009-01-16 00:00:00

abstract：:Leucogenenol a heterocyclic enolic thymothyroid hormone (MW 383) whose concentration in the serum regulates the rate at which already committed cells of the bone marrow develop into functional cells, was found to be associated in the thymus with a carrier protein. The carrier protein for leucogenenol is not precipitat...

journal_title：Life sciences

authors： Rice FA,McCurdy JD,Heath JR

更新日期：1984-07-30 00:00:00

abstract：:The scientific interest in irisin, a myokine discovered in 2012, has grown exponentially in recent years. Irisin, which is mainly produced in skeletal muscle, influences the browning process of adipose tissue and lipid and energy metabolism. Recent discoveries highlight that the potential of this hormone may have been...

journal_title：Life sciences

authors： Flori L,Testai L,Calderone V

更新日期：2021-02-15 00:00:00

abstract：:Vanadate has been suggested as an intracellular regulator of (Na+ + K+)-ATPase. To test this hypothesis we examined the stimulatory and inhibitory effects of vanadate on 86--Rb efflux and influx (measurements of the activity of the Na-pump) in rat ileum under conditions of normal, reduced and increased (Na+ + K+)-ATPa...

journal_title：Life sciences

authors： Hajjar JJ,Rowe WA,Tomicic TK

更新日期：1988-01-01 00:00:00

abstract：AIMS:Brain injuries based on their causes are divided into two categories, TBI and NTBI. TBI is caused by damages such as head injury, but non-physical injury causes NTBI. Prolactin is one of the blood factors that increase during brain injury. It has been assumed to play a regenerative role in post-injury recovery. M...

journal_title：Life sciences

authors： Yousefvand S,Hadjzadeh MA,Vafaee F,Dolatshad H

更新日期：2020-12-15 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are integral membrane proteins that, in response to activation by extracellular stimuli, regulate intracellular second messenger levels via their coupling to heterotrimeric G proteins. GPCR activation also initiates a series of molecular events that leads to G protein-coupled recept...

journal_title：Life sciences

authors： Seachrist JL,Ferguson SS

更新日期：2003-12-05 00:00:00

abstract：:Puromycin is an experimental anti-tumor antibiotic acting through inhibition of protein synthesis. Because of its untoward side effects (as inner ear and renal lesions) the antibiotic was not approved for clinical trials. The mechanism underlying the organ specificity of the side effect is not understood. In view of t...

journal_title：Life sciences

authors： Wrześniok D,Surazyński A,Karna E,Buszman E,Pałka J

更新日期：2005-06-17 00:00:00

abstract：:An in vitro perifusion system was used to investigate the effects of GnRH stimulation on LH, ACTH, and immunoreactive beta-endorphin (i beta-END) release from ovariectomized (1 week) rat anterior hemipituitaries. Either 0, 8 or 80 nM GnRH was administered as a 15 min pulse followed 30 min later by a prolonged 45 min i...

journal_title：Life sciences

authors： Gambacciani M,Yen SS,Rasmussen DD

更新日期：1988-01-01 00:00:00

abstract：:This in vitro study was conducted to determine whether tachyphylaxis of guinea pig airway to furosemide occurs under conditions that produce tachyphylaxis to the beta 2-adrenoceptor agonist, salbutamol. Isometric tension was measured in tracheal rings bathed in HEPES buffer from 4-6 d newborn guinea pigs of either sex...

journal_title：Life sciences

authors： Iwamoto LM,Wilson VL,Lavallee SL,Fujiwara N,Ayau EL,Nakamura KT

更新日期：1996-01-01 00:00:00

abstract：AIMS:Amino acids, especially branched chain amino acids (BCAAs), have important regulatory roles in protein synthesis. Recently studies revealed that BCAAs protect against ischemia/reperfusion (I/R) injury. We studied the signaling pathway and mitochondrial function affecting a cardiac preconditioning of BCAAs. MAIN M...

journal_title：Life sciences

authors： Satomi S,Morio A,Miyoshi H,Nakamura R,Tsutsumi R,Sakaue H,Yasuda T,Saeki N,Tsutsumi YM

更新日期：2020-03-15 00:00:00

abstract：AIMS:Ovarian cancer (OC) is the most lethal gynecologic malignant tumors all over the world. HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) has been reported as an important regulator in multiple tumors. However, the functions of HOTAIRM1 in OC and its possible molecular mechanisms remain unclear. MAIN METHODS:qRT-...

journal_title：Life sciences

authors： Chao H,Zhang M,Hou H,Zhang Z,Li N

更新日期：2020-02-15 00:00:00

abstract：:We measured the concentration of immunoreactive (IR) hEGF in various body fluids by radioimmunoassay (RIA) and evaluated its size heterogeneity by size exclusion high performance liquid chromatography combined with RIA or with time-resolved immunofluorometric assay (TR-IFMA). Mean concentration was 80 ng/ml in urine, ...

journal_title：Life sciences

authors： Pesonen K,Viinikka L,Koskimies A,Banks AR,Nicolson M,Perheentupa J

更新日期：1987-06-29 00:00:00

abstract：:The effect of prior incubation with a single concentration of isoproterenol (10(-4) M) for 2 hours at 37 degrees C on isoproterenol-stimulated cyclic AMP accumulation in intact lymphocytes from young, old and subjects with Alzheimer's disease was studied. In lymphocytes from all three subjects groups prior incubation ...

journal_title：Life sciences

authors： Oppenheim G,Mintzer J,Halperin Y,Eliakim R,Stessman J,Ebstein RP

更新日期：1984-10-22 00:00:00

abstract：:We have proposed that the atypical opioid system in the mouse may be representative of that in the anorexia nervosa patient and may account for a biological predisposition to the disorder. This is in the context of our auto-addiction model of anorexia nervosa in which endogenous opioids play a critical role in its eti...

journal_title：Life sciences

authors： Marrazzi MA,Mullings-Britton J,Stack L,Powers RJ,Lawhorn J,Graham V,Eccles T,Gunter S

更新日期：1990-01-01 00:00:00

abstract：:The effects of cloricromene, a coumarine derivative, were studied in an anaesthetized rat model of coronary artery ligation (60 min) followed by reperfusion (60 min; MI/R). Sham operated rats were used as controls (Sham MI/R). Myocardial ischaemia-reperfusion injury produced a marked myocardial injury (necrotic area/a...

journal_title：Life sciences

authors： Squadrito F,Altavilla D,Zingarelli B,Ioculano M,Calapai G,Campo GM,Miceli A,Prosdocimi M,Caputi AP

更新日期：1993-01-01 00:00:00

abstract：:The effects of various vasorelaxant agents on aortas from control and genetically diabetic rats were examined. The concentration-response curves for the isoproterenol (ISO)-induced relaxation of both aortic strips with and without endothelium are shifted to the right in diabetic rats. The relaxation responses of diabe...

journal_title：Life sciences

authors： Miyata N,Yamaura H,Tsuchida K,Otomo S,Kamata K,Kasuya Y

更新日期：1992-01-01 00:00:00