Abstract：
:Leucogenenol a heterocyclic enolic thymothyroid hormone (MW 383) whose concentration in the serum regulates the rate at which already committed cells of the bone marrow develop into functional cells, was found to be associated in the thymus with a carrier protein. The carrier protein for leucogenenol is not precipitated by heating to 80 degrees but following this treatment leucogenenol is precipitated in association with proteins precipitated by acetone and then by saturated ammonium sulfate. On chromatography on Sephacryl G-200 it was found that leucogenenol was associated with proteins of MW approximately 38,000. Leucogenenol is not eluted from the chromatographic column if it is not associated with its carrier proteins. It is suggested that other hormones such as those associated with the reproductive cycle or compounds that result from tissue damage induce the liberation of leucogenenol from its carrier protein in the thymus to the circulation where it is associated as previously described, with a protein of approximately MW 300,000.
journal_name
Life Scijournal_title
Life sciencesauthors
Rice FA,McCurdy JD,Heath JRdoi
10.1016/0024-3205(84)90245-5subject
Has Abstractpub_date
1984-07-30 00:00:00pages
517-23issue
5eissn
0024-3205issn
1879-0631pii
0024-3205(84)90245-5journal_volume
35pub_type
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