Abstract：
AIMS:Oxidative stress is involved in cholestasis-induced hepatic damage. Therefore, antioxidant therapy is a recommended therapeutic strategy. Studies have illustrated that chromium can enhance antioxidative capacity leading to a resolution of oxidative stress. The aim of this study was to assess whether chromium has protective effects against cholestasis-related liver damage. MAIN METHODS:Cholestasis was produced by bile duct ligation (BDL) in male Sprague-Dawley rats for 3 weeks. Rats were randomly divided into four groups. Control and BDL groups were subjected to sham and BDL operation, respectively, and were supplemented with placebo for 3 weeks. The BDL-post Cr group was supplemented with chromium chloride for 3 weeks after BDL operation. The BDL-pre Cr group was supplemented with chromium chloride for 6 weeks starting from 3 weeks before BDL operation. KEY FINDINGS:In comparison with the control group, the BDL group showed hepatic damage as evidenced by elevation in serum biochemicals, ductular reaction, and fibrosis. These pathophysiological changes were attenuated in the BDL-Pre Cr and BDL-Post Cr groups. However, there was no significant difference between these two groups. The anti-fibrotic effect of chromium was accompanied by reductions in alpha-smooth muscle actin-positive matrix-producing cells and Smad 2/3 activity critical to the fibrogenic potential of transforming growth factor beta 1 (TGF-beta1). In addition, chromium effectively attenuated BDL-induced hepatic oxidative stress. SIGNIFICANCE:The data indicate that chromium attenuates BDL-induced cholestatic liver injury, bile duct proliferation, and fibrosis. The hepatoprotective effect of chromium is associated with antioxidative potential.
journal_name
Life Scijournal_title
Life sciencesauthors
Chen WY,Chen CJ,Liao JW,Mao FCdoi
10.1016/j.lfs.2009.02.003subject
Has Abstractpub_date
2009-04-24 00:00:00pages
606-14issue
17-18eissn
0024-3205issn
1879-0631pii
S0024-3205(09)00066-6journal_volume
84pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Melanin in the skin determines the skin color, and decreased melanin causes many hypopigmentation disorders and increased damage to skin by ultraviolet B (UVB) light irradiation. Here, we stimulate melanogenesis in B16F10 melanoma cells by using specific frequencies of ELF-EMFs. In this study, we focus on the melanoge...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.08.015
更新日期：2016-10-01 00:00:00
abstract：:Decreased sweat secretion is a primary side effect of topiramate in pediatric patients, but the mechanism underlying this effect remains unclear. This study aimed to better understand how topiramate decreases sweat secretion by examining its effect on the expression of carbonic anhydrase (CA) II and aquaporin-5 (AQP5)...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.04.018
更新日期：2007-06-06 00:00:00
abstract：:Single smooth muscle cells from rat tail artery and ventricular myocytes from neonatal rat were isolated by repeated enzyme digestion. The change in cell area as determined photographically was used as an index of cell contraction. The photographic areas of single smooth muscle cells bathed in normal Tyrode solution w...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90077-g
更新日期：1993-01-01 00:00:00
abstract：:NMDA receptors are involved in the modulation of neuropathic pain behavior and central sensitization. In vivo, this is mostly demonstrated by the use of specific antagonists such as MK801. Because studies evaluating the direct impact of spinal NMDA in neuropathic pain models are lacking, we performed a series of exper...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.10.068
更新日期：2005-06-10 00:00:00
abstract：AIMS:Mancozeb is a dithiocarbamate fungicide known to be genotoxic and induces tumors in rodents at various sites. There is no report in the literature about its genotoxicity in humans. Here, we investigated the association between mancozeb exposure and induction of genotoxic and proapoptotic changes in cultured human ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.12.013
更新日期：2012-06-06 00:00:00
abstract：:To clarify the mechanism of meconium-induced cellular injury, we examined the effect of meconium on the alveolar macrophages (AM) and bronchial epithelial cells (AK-D). Meconium obtained from healthy newborns was added to culture medium of AM and/or AK-D, which were cultured for 1 hour. Superoxide anion production of ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90026-4
更新日期：1994-01-01 00:00:00
abstract：AIMS:Amino acids, especially branched chain amino acids (BCAAs), have important regulatory roles in protein synthesis. Recently studies revealed that BCAAs protect against ischemia/reperfusion (I/R) injury. We studied the signaling pathway and mitochondrial function affecting a cardiac preconditioning of BCAAs. MAIN M...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117368
更新日期：2020-03-15 00:00:00
abstract：:The present study was designed to investigate the effects of the intrahippocampal co-injection of beta-amyloid protein1-40 (Abeta(1-40)) with ibotenic acid (Ibo) on learning and memory in normal and aging model rats, and to explore the mechanism underlying the effects of the co-injection. The normal and aging rats wer...
journal_title：Life sciences
pub_type： 杂志文章,收录出版
doi：10.1016/j.lfs.2004.05.039
更新日期：2005-01-28 00:00:00
abstract：:The potential photoaffinity ligand 14-beta-(o-nitro, p-azido)-cinnamoyl-amino-N-cyclopropylmethylnormorphinone (NAM) and its derivative NOM, lacking the p-azido function, were synthesised and their opiate receptor activity determined in isolated tissue preparations. The ligands showed slow receptor kinetics. NAM was a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90536-2
更新日期：1983-01-01 00:00:00
abstract：:The multidrug transporter MDR1 (P-glycoprotein)-mediated interaction between digoxin and 29 antihypertensive drugs of various types was examined by using the MDR1 overexpressing LLC-GA5-COL150 cells, which were established by transfecting MDR1 cDNA into porcine kidney epithelial LLC-PK1 cells. These cells construct mo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01494-1
更新日期：2002-02-15 00:00:00
abstract：AIMS:Evidence has indicated U50,488H, a selective κ-opioid receptor (κ-OR) agonist, administered before ischemia attenuates apoptosis and infarction during ischemia and reperfusion (I/R). However, it remains unclear whether U50,488H postconditioning reduces apoptosis during I/R. This study was designed, therefore, to t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.10.018
更新日期：2011-01-03 00:00:00
abstract：:Obesity is caused by energy imbalance and accompanied by adipocyte hypertrophy and hyperplasia. Therefore, both enhancement of adipocyte energy expenditure and inhibition of adipogenesis are viable ways to combat obesity. Using the Ucp1-2A-luciferase reporter animal model previously reported by us as a screening platf...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.01.047
更新日期：2019-04-01 00:00:00
abstract：AIMS:Cisplatin (CDDP) is a potent anticancer agent, but severe renal toxicity can limit its use. We investigated the protective effect of cepharanthin (CE), a biscoclaurin alkaloid, on the renal toxicity of CDDP. MAIN METHODS:Mice were given CDDP along with CE. Effects of CE on CDDP toxicity were investigated by assay...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.01.031
更新日期：2013-04-09 00:00:00
abstract：:Extracellular phospholipase A2 (PLA2) with proinflammatory activity has recently been discovered in synovial fluids in inflammatory arthritides. In the search for the sources of synovial fluid PLA2, human synovium and articular cartilage were found to contain large quantities of the enzyme. In rheumatoid arthritis (RA...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90381-k
更新日期：1991-01-01 00:00:00
abstract：:This study examines the influence of ovariectomy and administration of a pharmacologic dose of estradiol on amylase release from isolated-dispersed rat pancreatic acini and cholecystokinin receptors on rat acinar cell membranes. Rats were sham ovariectomized (intact) or ovariectomized (Ovx) and 21 day timed release pe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90281-f
更新日期：1991-01-01 00:00:00
abstract：AIMS:Insulinoma-associated protein 2β (IA-2β) is considered to play a significant role in regulated secretion. Recent studies have shown that the mouse brain expresses three major isoforms of IA-2β, named IA-2β60, IA-2β64, and IA-2β71. In this study, we analyzed the tissue-, cell- and organelle-specific distributions o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.02.018
更新日期：2011-04-25 00:00:00
abstract：AIMS:Nanoparticles (NPs)-based drugs have been recently introduced to improve the efficacy of current therapeutic strategies for the treatment of cancer; however, the molecular mechanisms by which a NP interacts with cellular systems still need to be delineated. Here, we utilize the autophagic potential of TiO2 NPs for...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117466
更新日期：2020-05-01 00:00:00
abstract：:The object of this study was to develop an assay for platelet activating factor (PAF) in rat plasma, and to utilise this to determine the effects of dietary fish oil on PAF in normotensive and spontaneously hypertensive rats. Measurement of platelet activating factor in blood plasma has proved difficult because of its...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90143-8
更新日期：1986-05-19 00:00:00
abstract：:In an in vitro bioassay system for adrenocorticotropic hormone using isolated rat adrenal cells, kaurenol, a diterpene alcohol, stimulated corticosterone production and augmented the steroidogenic effect of adrenocorticotropin or forskolin, dose-dependently. Kaurenol had no effect on cyclic AMP production by the cells...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90070-6
更新日期：1986-02-03 00:00:00
abstract：:BIM 23014 is a somatostatin analog displaying an increased biological half life due to resistance to enzymatic degradation. This peptide inhibits GH release directly at the level of pituitary somatotrophs. In addition, an action of BIM 23014 at the level of the hypothalamus is possible since somatostatinergic fibers a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90610-2
更新日期：1992-01-01 00:00:00
abstract：:We studied effects of tyrphostin A23 (an inhibitor of protein tyrosine kinase; PTK) and tyrphostin A63 (an inactive analog of tyrphostin A23) on forskolin-activated cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels and Cl(-) secretion in renal epithelial A6 cells. Tyrphostin A23 and A63 had no ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01824-6
更新日期：2002-07-26 00:00:00
abstract：:Neurodegenerative diseases need the drugs to be delivered right inside the brain to maximizing the therapeutic effects. This can be achieved by use of novel targeted delivery systems such as nanoemulsions. Nanoemulsions (NE) are nano-sized emulsions that are manufactured for enhancing the delivery of drugs to the targ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.117394
更新日期：2020-03-15 00:00:00
abstract：AIMS:The protein kinase C (PKC) family of enzymes has been implicated in cellular proliferation, differentiation, and apoptosis. However, the distribution of specific PKC isoforms with varying functions in normal and malignant human tissues remains to be determined. The objective of this study was to investigate the ex...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.03.007
更新日期：2009-05-22 00:00:00
abstract：:An increase in the weight of the thyroid gland, accompanied by reductions in uptake and release of 1311, serum T3 and reverse T3 concentrations and an increase in serum TSH concentration, occurs during the development of renal hypertension in rats. Renal function, as assessed by BUN, serum and urinary creatinine conce...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90274-0
更新日期：1982-02-15 00:00:00
abstract：:The bone marrow is home to mesenchymal stem cells (MSCs) that are able to differentiate into many different cell types. The effect of hyperbaric oxygen (HBO) on MSCs is poorly understood. Placental growth factor (PlGF) is an attractive therapeutic agent for stimulating revascularization of ischemic tissue. HBO has bee...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.05.005
更新日期：2008-07-04 00:00:00
abstract：:In order to explore the effect of neonatal androgen administration on oocyte quality, ovulation induction and in vitro fertilization (IVF) were performed in androgen-sterilized mice. Androgen sterilized mice were produced by the subcutaneous injection of testosterone propionate (TP) at 5 days of age and ovulation indu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00745-4
更新日期：1994-01-01 00:00:00
abstract：AIMS:To investigate the therapeutic effects of human amniotic mesenchymal stem cells (hAMSCs) on paraquat (PQ)-induced pulmonary fibrosis in rats and investigate the inflammatory mechanisms. MAIN METHODS:hAMSCs were identified by morphological, flow cytometry and immunocytochemistry. A pulmonary fibrosis model was ind...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117290
更新日期：2020-02-15 00:00:00
abstract：:Oxidative stress has been implicated to play an important role in the pathogenesis of diabetic neuropathy, which is the most common complication of diabetes mellitus affecting more than 50% of diabetic patients. In the present study, we have investigated the effect of U83836E [(-)-2-((4-(2,6-Di-1-pyrrolidinyl-4-pyrimi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.02.033
更新日期：2006-07-17 00:00:00
abstract：AIMS:Major depressive disorder, as a destructive mental health disorder, is a major contributor to disability and death. Numerous studies have illustrated that activation of inflammation and fluctuating immune reactions play a crucial role in the physiopathology of depression. The effectiveness of antidepressants is af...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118501
更新日期：2020-12-01 00:00:00
abstract：:Previous in vitro evidence suggests that adrenaline causes K influx in skeletal muscle by stimulating a ouabain sensitive Na/K ATPase membrane pump. However in rabbits, adrenaline induced hypokalaemia was not significantly altered by pretreatment with digoxin (50 micrograms/kg). Rats were infused with adrenaline or sa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90258-x
更新日期：1987-01-05 00:00:00
