Estrogens influence cholecystokinin stimulated pancreatic amylase release and acinar cell membrane cholecystokinin receptors in rat.

abstract：:The effects of agents that modulate intracellular release of calcium and protein kinase C (PKC) activation on noradrenaline (NA)-induced contractions of epididymal vas deferens in calcium-free/EGTA (1 mM) medium were investigated. NA (100 microM) or methoxamine (100 microM) evoked repeatable contractions. Clonidine (1...

journal_title：Life sciences

authors： Amobi NI,Sugden D,Smith IC

更新日期：1999-01-01 00:00:00

abstract：:The effect of polyamines on the catalytic domain of protein kinase C from rat brain was investigated. It was found that the addition of spermine strongly inhibited phosphorylation activity toward histone H1 as substrate. This tetramine, at millimolar concentrations, was most potently effective while triamines and diam...

journal_title：Life sciences

authors： Mezzetti G,Monti MG,Moruzzi MS

更新日期：1988-01-01 00:00:00

abstract：:The hypoglycemic and hypolipidemic effects of Lycium barbarum fruit water decoction, crude polysaccharide extracts (crude LBP), and purified polysaccharide fractions (LBP-X) in alloxan-induced diabetic or hyperlipidemic rabbits were investigated through designed sequential trials and by measuring blood glucose and ser...

journal_title：Life sciences

authors： Luo Q,Cai Y,Yan J,Sun M,Corke H

更新日期：2004-11-26 00:00:00

abstract：:The renal hemodynamic and tubular effects of ANF were investigated using the Sperber technique in chickens. This technique takes advantage of the unique portal circulation of the avian kidney and permits direct access to the renal peritubular space independent of renal arterial blood flow and glomerular filtration. In...

journal_title：Life sciences

authors： Springate JE,Fildes RD,Hong SK,Feld LG,Acara M

更新日期：1987-03-09 00:00:00

abstract：:The binding of membrane immunoglobulin (mIg) by anti-Ig antibodies is known to initiate a mitogenic signal in B lymphocytes. Because in many instances growth control appears to be correlated with phosphokinase activity, as well as with alterations in cytoskeletal architecture, we asked the question whether antibodies ...

journal_title：Life sciences

authors： Rosenspire AJ,Choi YS

更新日期：1988-01-01 00:00:00

abstract：:The binding of biologically active 125I-Bolton-Hunter (BH)-NPY to rat brain membranes was saturable and reversible and regulated by inorganic cations and guanyl nucleotides consistent with other neurotransmitter receptor systems. The concentration of specific 125I-NPY binding differed in various brain regions, being h...

journal_title：Life sciences

authors： Chang RS,Lotti VJ,Chen TB,Cerino DJ,Kling PJ

更新日期：1985-12-02 00:00:00

abstract：:Thalidomide (Thd) was given in two trials (total daily dose: 5 or 8 mg Thd/kg body weight, respectively) for five and three days to a healthy male volunteer, and various receptors were analyzed on white blood cells before, during and after (up to 30 days) the treatment period. There were neither marked deviations in t...

journal_title：Life sciences

authors： Neubert R,Nogueira AC,Neubert D

更新日期：1992-01-01 00:00:00

abstract：AIMS:RNA regulatory genes were closely associated with tumorigenesis and prognosis in multiple tumors. Copy number variation (CNV) is a frequent characteristic in soft tissue sarcomas (STS). However, little is known regarding their possible roles in STS. MAIN METHODS:RNA sequence profiles and CNV data of 255 STS patie...

journal_title：Life sciences

authors： Wang X,Han Y,Li J,Hong D,Xue Z,Huang H,Du Z,Hou Y,Li H,Li H,Liao H,Xie X,Ding C

更新日期：2021-01-15 00:00:00

abstract：:Arginine vasotocin has been proposed as a hormone of the mammalian pineal gland. This claim is largely based on biological and immunological results, although some chemical evidence has also been provided. Yet, more and more researchers have recently disclaimed the presence of this nonapeptide in mammalian tissue. The...

journal_title：Life sciences

authors： Nieuwenhuis JJ

更新日期：1984-10-22 00:00:00

abstract：:We describe here a nonpeptide neuropeptide Y Y1 receptor antagonist, 2,4-dioxo-1,5-bis(2-oxo-2-orthotolyl-ethyl)-3-[3-[3-([3-[3-(3-p iperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propyl]-car bamoyloxymethyl)-phenyl]-ureido]-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diaz epine (Compound 1), which was previously synthesized as...

journal_title：Life sciences

authors： Shigeri Y,Ishikawa M,Ishihara Y,Fujimoto M

更新日期：1998-01-01 00:00:00

abstract：:Increasing understanding in tumor pathology reveals that tumor microenvironment (TME), which supports tumor progression and poses barriers for available therapies, takes a great responsibility in inefficient treatment and poor prognosis. In recent years, the versatile nanotechnology employed in TME regulation has made...

journal_title：Life sciences

authors： Li M,Zhang F,Su Y,Zhou J,Wang W

更新日期：2018-05-15 00:00:00

abstract：:Transcription factor Gata3 is implicated in the formation of autosomal dominant hypoparathyroidism, sensorineural deafness, and renal anomaly (HDR) syndrome. We pursued to identify the potential Gata3 target genes by profiling the gene expression pattern in E9.5 Gata3-/- mouse embryos. Altogether four independent micr...

journal_title：Life sciences

authors： Airik R,Kärner M,Karis A,Kärner J

更新日期：2005-04-15 00:00:00

abstract：:We administered a series of alpha-blocking drugs to the nucleus reticularis lateralis (NRL) of the medulla oblongata, the main site for the hypotensive action of clonidine. These experiments were performed on pentobarbital anaesthetized cats. Drugs were injected through a needle which was stereotaxically inserted. Pra...

journal_title：Life sciences

authors： Bousquet P,Feldman J

更新日期：1987-03-16 00:00:00

abstract：AIMS:The rational basis that explains the benefits of exercise therapy on Chagas cardiomyopathy (ChC) is poorly understood. This study investigated the impact of an exercise program on exercise performance, heart parasitism, immunoinflammatory response, fibrogenesis, oxidative damage, and cardiomyocytes contractility i...

journal_title：Life sciences

authors： Novaes RD,Gonçalves RV,Penitente AR,Bozi LH,Neves CA,Maldonado IR,Natali AJ,Talvani A

更新日期：2016-05-01 00:00:00

abstract：:Site-directed mutagenesis has been used to evaluate the roles of the key aspartate and arginine residues in transmembrane domain three of the muscarinic receptors. The results suggest that the formation of an ionic bond between the Asp carboxylate group and the onium headgroup is essential to anchor acetylcholine in i...

journal_title：Life sciences

authors： Hulme EC,Curtis CA,Page KM,Jones PG

更新日期：1995-01-01 00:00:00

abstract：AIMS:Opioid addiction is associated with long-term adaptive changes in the brain that involve protein expression. The carboxyl-terminal of the μ opioid receptor (MOR-C) is important for receptor signal transduction under opioid treatment. However, the proteins that interact with MOR-C after chronic morphine exposure re...

journal_title：Life sciences

authors： Zhou P,Jiang J,Dong Z,Yan H,You Z,Su R,Gong Z

更新日期：2015-12-15 00:00:00

abstract：AIMS:Cancer Stem Cells (CSCs) refers to heterogeneous tumor cells retaining the abilities of self-renewal and differentiation. This study used mRNAsi, which is an index to describe the similarity between tumor cells and CSCs, to define genes involved in endometrial carcinoma. MATERIALS AND METHODS:The mRNA expression ...

journal_title：Life sciences

authors： Liu J,Wu Z,Sun R,Nie S,Meng H,Zhong Y,Nie X,Cheng W

更新日期：2020-10-01 00:00:00

abstract：:Several antihistamines were evaluated for their ability to interact with sigma, muscarinic and histaminic H1 binding sites in rat brain preparations. All of the antihistamines were able to interact with the sigma site, as well as the other two sites. In addition, tripelennamine was found to elicit sigma-like behaviors...

journal_title：Life sciences

authors： Gray NM,Contreras PC,Allen SE,Taylor DP

更新日期：1990-01-01 00:00:00

abstract：AIMS:Ginsenoside-Rg1 (G-Rg1), a saponin that is a primary component of ginseng, is very useful and important in traditional Chinese medicine for stroke. The objective of this study was to explore the mechanisms underlying the neuroprotective effect of G-Rg1 on focal cerebral ischemia/reperfusion. MAIN METHODS:Focal ce...

journal_title：Life sciences

authors： Xie CL,Li JH,Wang WW,Zheng GQ,Wang LX

更新日期：2015-01-15 00:00:00

abstract：:The presence of neuropeptide tyrosine (NPY) in the intermediate lobe of the frog pituitary was demonstrated using indirect immunofluorescence, the immunogold technique and a specific radioimmunoassay combined with high pressure liquid chromatography (HPLC). A high density of NPY-containing fibers, was found among the ...

journal_title：Life sciences

authors： Danger JM,Leboulenger F,Guy J,Tonon MC,Benyamina M,Martel JC,Saint-Pierre S,Pelletier G,Vaudry H

更新日期：1986-09-29 00:00:00

abstract：:Liquid chromatography of porcine duodenal extracts, in conjugation with bioassay on guinea-pig ileum myenteric plexus longitudinal muscle preparation, yielded substances which inhibited electrically-evoked twitches of the preparations, but whose actions could not be reversed by naloxone, an opioid antagonist. The subs...

journal_title：Life sciences

authors： Arakawa Y,Tachibana S

更新日期：1984-12-17 00:00:00

abstract：:Since reduced levels of brain serotonin are known to cause behavioural abnormalities, to which diabetics are also prone, we investigated the effect, in rats, of chronic diabetes on brain serotonin concentration and on the numbers of 5-HT(1A) and 5-HT2 receptors in cerebral cortex and brainstem. Our data show that stre...

journal_title：Life sciences

authors： Sandrini M,Vitale G,Vergoni AV,Ottani A,Bertolini A

更新日期：1997-01-01 00:00:00

abstract：:In this paper, we describe the characterization of the expression of monoamine oxidase (MAO) in whole pancreas and in isolated islets of Langerhans from human. Classical monamine oxidase activity assays reveal that both isoforms A & B are present in human pancreas. Two complementary approaches indicated that both MAO ...

journal_title：Life sciences

authors： Pizzinat N,Chan SL,Remaury A,Morgan NG,Parini A

更新日期：1999-01-01 00:00:00

abstract：:To evaluate possible deleterious effects of commonly used herbicides on leukocytes, cytokine production was selected as a sensitive indicator. After in vitro exposure of human peripheral blood mononuclear cells from normal donors, the production of all 3 cytokines tested--interferon-gamma (a type 1 cytokine), interleu...

journal_title：Life sciences

authors： Hooghe RJ,Devos S,Hooghe-Peters EL

更新日期：2000-05-19 00:00:00

abstract：:The substituted glucopyranose ring structure 2-hydroxypropyl-beta-cyclodextrin (CDEX) increases the solubility of molecules by inclusion of the agent in the lipophilic interior of the ring. This property is of particular use for the administration of molecules by the intracerebral (ICV) or intrathecal (IT) routes. In ...

journal_title：Life sciences

authors： Yaksh TL,Jang JD,Nishiuchi Y,Braun KP,Ro SG,Goodman M

更新日期：1991-01-01 00:00:00

abstract：:Indomethacin (0.14-.5 mM concentration) inhibits nitric oxide production in murine peritoneal macrophages. This was evidenced by measuring both nitrite production or 14C-L-citrulline formation. The inhibition was caused by the diminution of de novo inducible nitric oxide synthase production as demonstrated by Western ...

journal_title：Life sciences

authors： Hrabák A,Vercruysse V,Kahán IL,Vray B

更新日期：2001-03-09 00:00:00

abstract：:Heart rate (HR) and mean arterial blood pressure (BP) were recorded from conscious, chair-restrained squirrel monkeys surgically prepared with chronically indwelling arterial and venous catheters to determine the effects of acute intravenous injections of two opiate antagonists and an agonist. Naloxone (0.3--10.0 mg/k...

journal_title：Life sciences

authors： Byrd LD

更新日期：1983-01-24 00:00:00

abstract：:These experiments were designed to test the hypothesis that cyclosporine A (CSA) inhibits renin secretion and stimulates renal prostaglandin E2 (PGE2) release in vitro. In rat renal cortical slices incubated at 37 degrees C in a buffered and oxygenated physiological saline solution containing 4 mM KCl, CSA concentrati...

journal_title：Life sciences

authors： Churchill PC,Rossi NF,Ellis VR,Churchill MC,McDonald FD

更新日期：1990-01-01 00:00:00

abstract：:Previous research has shown that the CAMK (calcium/calmodulin dependent protein kinase) inhibitor, KN62, can lead to reductions in insulin stimulated glucose transport. Although controversial, an L-type calcium channel mechanism has also been hypothesized to be involved in insulin stimulated glucose transport. The pur...

journal_title：Life sciences

authors： Wright DC,Fick CA,Olesen JB,Lim K,Barnes BR,Craig BW

更新日期：2004-01-02 00:00:00

abstract：:Alpha-lipoic acid (ALA), a potent biological antioxidant, improves insulin action of skeletal muscle glucose transport and metabolism in both human and animal models of insulin resistance. In order to obtain further insight into the potential intracellular mechanisms for the action of ALA on insulin-stimulated glucose...

journal_title：Life sciences

authors： Henriksen EJ,Jacob S,Streeper RS,Fogt DL,Hokama JY,Tritschler HJ

更新日期：1997-01-01 00:00:00