Abstract：
:Indomethacin (0.14-.5 mM concentration) inhibits nitric oxide production in murine peritoneal macrophages. This was evidenced by measuring both nitrite production or 14C-L-citrulline formation. The inhibition was caused by the diminution of de novo inducible nitric oxide synthase production as demonstrated by Western blotting experiment. The effect of indomethacin after 4 h treatment was irreversible. NO synthase and arginase activities and the uptake of arginine were not directly affected by the drug. Indomethacin also decreased uridine incorporation in macrophages. The effect of indomethacin on the induction of other enzymes (i.e. arginase) was weaker.
journal_name
Life Scijournal_title
Life sciencesauthors
Hrabák A,Vercruysse V,Kahán IL,Vray Bdoi
10.1016/s0024-3205(01)00978-xsubject
Has Abstractpub_date
2001-03-09 00:00:00pages
1923-30issue
16eissn
0024-3205issn
1879-0631pii
S002432050100978Xjournal_volume
68pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Addition of synthesized atriopeptin II (AP-2), a 23 amino acid peptide of rat atria, to rat thoracic aorta smooth muscle cells results in the stimulation of cyclic GMP production by the cells. The EC50 for the effect is 81 nM and a 7 fold increase occurs at 10 microM AP-2. Cyclic GMP levels increased within 15 seconds...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90425-4
更新日期：1985-08-19 00:00:00
abstract：AIMS:Nicotine is known to promote body weight loss and to disturb glucose homeostasis and lipoprotein metabolism. Electronic cigarettes, as a substitute to nicotine, are becoming increasingly popular, although there is no evidence regarding their safety. Considering the dearth of information about e-cigarette toxicity,...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.12.049
更新日期：2016-02-01 00:00:00
abstract：:The feasibility of using human cells isolated from peritoneal dialysis effluent as a model for studying lipoprotein and cholesterol metabolism was investigated. Human peritoneal cells degraded low density lipoproteins (LDL) and acetylated LDL (acetyl-LDL) by saturable, high affinity receptor-mediated processes. Positi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00138-5
更新日期：1996-01-01 00:00:00
abstract：AIMS:Hypoxia is implicated in the pathogenesis of rheumatoid arthritis (RA), contributing to the tumor-like phenotypes of RA fibroblast-like synoviocytes (RA-FLSs). Andrographolide is the main bioactive component of Andrographis paniculata, an herbal medicine that shows therapeutic benefits in RA patients. Here, we exp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.06.019
更新日期：2015-09-01 00:00:00
abstract：:BMP-3b is a novel BMP-3-related protein and its biological functions are unknown. In order to investigate the biological actions of BMP-3b, we constructed a BMP-3b-expressing recombinant adenoviral vector (AxCAKBMP-3b). We show that over expression of BMP-3b stimulated the induction of differentiation and the osteoind...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)02477-3
更新日期：2003-02-28 00:00:00
abstract：:In the CNS, dopamine (DA) is a recognized neurotransmitter as well as a precursor for norepinephrine (NE) and epinephrine (EPI). In contrast to the CNS, DA has been assumed to be only a precursor in peripheral tissues. There is now, however, considerable evidence to support the hypothesis that it may function as a neu...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(83)90827-5
更新日期：1983-04-11 00:00:00
abstract：AIMS:Dyslipidemia-associated diabetic retinopathy is featured by macular edema and retinal angiogenesis. This study investigated the in vitro lipotoxicity of free fatty acids and their modulatory roles in regulation of autophagy and angiogenic factor production in cultured human retinal pigment epithelium (RPE) ARPE-19...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118391
更新日期：2020-10-15 00:00:00
abstract：:Contractile responses to norepinephrine (NE), and the population of beta-adrenoceptors, were determined in gastric fundus smooth muscle from rats with diabetes induced by streptozotocin (STZ), and age-matched controls. Relaxation and/or contraction of fundus strips of controls and diabetics were induced by 10(-5)M NE....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90505-6
更新日期：1991-01-01 00:00:00
abstract：:Homocysteine (Hcy), an intermediate in methionine metabolism, has been proposed to be involved in hepatic fibrogenesis. Impaired liver function can alter Hcy metabolism. The aim of the present study was to determine plasma Hcy alterations in acute obstructive cholestasis and the subsequent biliary cirrhosis. Cholestas...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.12.009
更新日期：2005-04-08 00:00:00
abstract：:To investigate whether endogenous opioid peptides mediate time-dependent changes in ventilatory control during prolonged hypoxia, we studied four adult goats at rest during 14 days at simulated high altitude in a hypobaric chamber (PB approximately 450 Torr). Arterial PCO2 fell during the first several hours of hypoxi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90260-8
更新日期：1987-02-16 00:00:00
abstract：:A growing number of studies reported that rosiglitazone (a PPARgamma agonist) could ameliorate the painful state and prevent stress-induced depression. However, whether rosiglitazone can prevent pain-induced depression is unclear. This study aimed to explore the antidepressant effects of rosiglitazone in L5 spinal ner...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.04.057
更新日期：2018-06-15 00:00:00
abstract：:Coffee is consumed worldwide with greater than a billion cups of coffee ingested every day. Epidemiological studies have revealed an association of coffee consumption with reduced incidence of a variety of chronic diseases as well as all-cause mortality. Current research has primarily focused on the effects of coffee ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2015.11.005
更新日期：2015-12-15 00:00:00
abstract：:In rats with a unilateral 6-OHDA lesion of the substantia nigra exposure to footshock or immobilization stress produced a long-lasting enhancement in the rotational behavior evoked by a subsequent injection of amphetamine. However, the effect was dependent on the environmental context in which stress was applied. It i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90594-6
更新日期：1985-09-16 00:00:00
abstract：:Striatal D-2 dopamine (DA) antagonist and agonist binding sites were measured during the rat estrous cycle and compared to ovariectomized (OVX) rats. Dopaminergic D-2 antagonist binding sites were constant during the estrous cycle while agonist binding sites show a rapid and significant decrease of the ratio of high t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90137-3
更新日期：1988-01-01 00:00:00
abstract：:Although (-)-125I-iodopindolol (IPIN) can be used to label beta-adrenergic receptors in the central nervous system (CNS) in vivo, use of this ligand for receptor imaging studies in humans may be limited due to its relatively poor penetration into the CNS. A series of derivatives related to pindolol was therefore studi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90688-6
更新日期：1987-08-24 00:00:00
abstract：:In present study the methylotrophic yeast, Pichia pastoris, was used to express a recombinant growth hormone (rGH) gene of swine. A synthetic secretion cassette was constructed using the promoter of the alcohol oxidase1 gene (AOX1), and a alpha-factor signal peptide. After electroporatic transformation and zeocin sele...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00797-9
更新日期：2000-09-15 00:00:00
abstract：AIMS:The purpose of the study was to determine whether late therapeutic hypothermia (LTH), administered after reperfusion, could prevent adverse left ventricular (LV) remodeling and improve cardiac function in the rat myocardial ischemia/reperfusion model. MAIN METHODS:Rats were randomized to normothermia (n = 10) or ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.04.026
更新日期：2019-07-15 00:00:00
abstract：AIMS:To assess the relationship between endothelial dysfunction, endothelin 1 (ET-1) plasma levels and subclinical inflammation in primary open angle glaucoma (POAG) patients. MAIN METHODS:We enrolled 40 POAG patients with progressive visual field damage, although well controlled intraocular pressure (IOP) and compare...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.02.013
更新日期：2012-10-15 00:00:00
abstract：:Microvascular changes in the brain are significant causes of cerebral edema and ischemia injury. A number of studies suggest that angiotensin (Ang) II may be involved in the initiation and regulation of processes occurring in brain ischemia. We recently reported that Ang II injures brain microvascular endothelial cell...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.06.049
更新日期：2006-02-16 00:00:00
abstract：AIMS:We elucidated the therapeutic potential of human umbilical vein endothelial cells (HUVECs) for ameliorating progressive heart failure in a myocardial infarction (MI) rat model. MAIN METHODS:MI was induced by ligation of left anterior descending artery, and HUVEC was transplanted 1week after MI. Cardiac function w...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.02.009
更新日期：2014-04-17 00:00:00
abstract：:This work explored cellular trapping and extrusion of Cd and Hg in epithelial cells, with special emphasis on the jejunal mucosa. Important determinants of these processes are the concentration, diffusibility and relative metal affinities of a variety of cellular metal-binding compounds including metallothionein (MT)....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90042-2
更新日期：1993-01-01 00:00:00
abstract：:This paper describes a new formulation for triggered delivery of insulin which consisted of magnetic particles dispersed in alginate spheres. When magnetic field was applied to that system, the release rate of insulin was about 50 times higher than in the absence of magnetic field. The influence of oscillating magneti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90009-4
更新日期：1988-01-01 00:00:00
abstract：:Studies have adequately demonstrated the importance of maternal nutrition, particularly, micronutrients (folic acid, vitamin B12) and long chain polyunsaturated fatty acids (LCPUFAs) in determining pregnancy outcome. Reports indicate that children born preterm or to mothers with preeclampsia are at increased risk of d...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2014.09.026
更新日期：2015-05-15 00:00:00
abstract：AIMS:The aims of the study are to investigate whether the combination of adipose-derived stem cells (ADSCs) with decellularized extracellular matrix (dECM) of myocardium can exert synergistic therapeutic effects on acute MI and the underlying mechanism. MAIN METHODS:Myocardial dECM from fresh porcine myocardium was pr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116891
更新日期：2019-12-15 00:00:00
abstract：:Retinitis pigmentosa is a very heterogeneous group of retinal degenerations, with multiple genes identified in each mode of inheritance. For autosomal dominant retinitis pigmentosa (ADRP), the most common gene is the rhodopsin (RHO) gene, mutations in which contribute to about 25% of ADRP in Caucasian population. To i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.07.018
更新日期：2006-02-23 00:00:00
abstract：:Resveratrol, a polyphenolic substance found in grape skin, is proposed to account in part for the protective effect of red wine in the cardiovascular system. The aim of the present study is to investigate the action and possible mechanisms of resveratrol-produced regulation of plasma glucose in normal and diabetic rat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.02.002
更新日期：2007-04-10 00:00:00
abstract：:Endogenous levels of salsolinol and dopamine were measured by a gas chromatography/mass spectrometry (GC/MS) - selected ion monitoring technique using deuterated internal standards in Long Evans rats chronically exposed to ethanol for ten months. Chronic ethanol exposure produced significant increases of dopamine and ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90115-8
更新日期：1985-01-28 00:00:00
abstract：:Cyclic octapeptide analogues of somatostatin (SS) like SMS 201-995 [H-(D) Phe-Cys-Phe-(D) Trp-Lys-Thr-Cys-Thr(ol)] or its Tyr3-derivative 204-090, displaced [125I-Tyr11]-SS 100% from pancreatic membranes but only 62-75% from brain membranes; the remaining sites were displaced by SS. These data indicate that some mini-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90155-9
更新日期：1985-05-13 00:00:00
abstract：:In murine splenocytes, a primary antigen-specific antibody response is stimulated by 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), a stable form of ascorbate, as described in our previous paper. We examined here the effect of nerve growth factor (NGF) on the antigen-specific antibody production in vitro augmente...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00561-9
更新日期：1996-01-01 00:00:00
abstract：:The NLRP3 inflammasome regulates innate immune and inflammatory responses by promoting pro-inflammatory cytokines such as IL-18 and IL-1β. NLRP3 is one of the main factors restricting the activation of the inflammasome, which is closely related to the abundance and localization of NLRP3. A substantial number of studie...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118918
更新日期：2021-02-15 00:00:00
