Abstract：
:Addition of synthesized atriopeptin II (AP-2), a 23 amino acid peptide of rat atria, to rat thoracic aorta smooth muscle cells results in the stimulation of cyclic GMP production by the cells. The EC50 for the effect is 81 nM and a 7 fold increase occurs at 10 microM AP-2. Cyclic GMP levels increased within 15 seconds after the addition of AP-2 and were maximal at 5 minutes. Cyclic GMP levels in primary rabbit kidney cells were increased 15 fold by 10 microM AP-2. However, no increase in cyclic GMP was detected in WI-38 fibroblast cells after the addition of 10 microM AP-2. Cyclic AMP levels were not affected by AP-2 in any of these cell systems. The effect upon cyclic GMP accumulation was specific for AP-2; none of the other compounds or peptides tested affected cyclic GMP levels.
journal_name
Life Scijournal_title
Life sciencesauthors
Harris DW,Baker CA,Saneii HH,Johnson GAdoi
10.1016/0024-3205(85)90425-4subject
Has Abstractpub_date
1985-08-19 00:00:00pages
591-7issue
7eissn
0024-3205issn
1879-0631pii
0024-3205(85)90425-4journal_volume
37pub_type
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